Endocrine Abstracts

Aim of the study: The objectives of this study were to determine the regulation of glycemia (measured by fasting glucose levels and HbA1c) in patients with type 2 diabetes and to examine whether there is a difference in therapy (oral antidiabetics, insulin, combination), age, sex and BMI.Study design: Cross-sectional research with historical data.Patients: The study included 102 patients of both sexes (56% women and 44% men) with a...

Background: Type 1 diabetes mellitus (T1DM) is caused by destruction of pancreatic beta cells. Children and adolescents with type 1 diabetes have an increased risk of developing other autoimmune diseases, most commonly autoimmune thyroiditis and celiac disease.Objectives: To examine the frequency of individual human leukocyte antigen (HLA) alleles in people with T1DM and associated autoimmune (AI) diseases of the thyroid, digestive system, and skin, and ...

Aim of the Study: The main objectives were to examine the incidence of hyperlipoproteinemia in postmenopausal women and to determine the differences in lipid profile considering age, duration of menopause and body mass index in postmenopausal women.Material and Methods: The research was structured as a cross-sectional research with historical data. The research used data collected during regular check-ups in primary health care clinics in the Osijek Heal...

Medical documentation of 976 patients treated and followed-up over the years 2001–2006 at our 131- radioiodine treatment centre was analysed with respect to their thyroid cancer staging. The mean age at their time of diagnosis was 59±15.1 years. From histopathology, papillary, follicular or poorly differentiated cancer was diagnosed in 87.6, 11.7, and 0.7% of these patients, respectively. The mean ages of patients with papillary, follicular or poorly differentiated c...

Introduction: Many endocrinopathies such as acromegaly, Cushing’s syndrome (CS), pheomochromocytom and lipodystrophia can be associated with insülin resistance and unregulated diabetes mellitus (DM).Case report: A 37 –year- and 2 months pregnant women admitted to our out patient clinic for regulation of hyperglycemia. On physical examination; Blood Pressure: 140/95 mmHg, Body Mass Index: 31 kg/m2, central obesity, acanthosis nig...

Introduction: Parathyroid gland proliferative disorders include adenoma, hyperplasia and carcinoma. Adenoma and hyperplasia are found more commonly in women, while carcinoma, which is very rare, is found in both sexes equally. The aim of this study was to investigate parathyroid gland tumors surgically removed at University Hospital Centre Osijek between 2016 and 2019. Also to review tumor location, size and histopathology and compare sex difference.Pati...

Background: Thyroid hormone is essential in foetal neurological development and thyroid hormone deficiency in pregnant women has been linked to lower intelligence quotient and underperformance in their children later in life. Thyroid hormone requirement increases during pregnancy by approximately 50% in the first trimester. We audited our practice of increasing thyroid hormone dose at booking and thereafter in pregnant women attending our combined obstetric medical clinic....

P450 Oxidoreductase Deficiency (ORD) is a novel form of congenital adrenal hyperplasia with biochemical evidence of combined 21-hydroxylase and 17α-hydroxylase deficiency. Mutations in P450 oxidoreductase (POR), a crucial electron donor to microsomal P450 enzymes including CYP17 and CYP21, have recently been identified as the cause of disease. Clinical features in ORD include ambiguous genitalia, glucocorticoid deficiency and craniofacial malformations resembling the Antl...

Background: Syncope is a transient loss of consciousness resulting from cerebral hypoperfusion. Despite the extensive efforts by the scientific community over decades, the pathophysiology remains unclear. Although syncope itself is a reversible, short-lasting, benign condition, it negatively impacts quality of life. Vasovagal syncope (VVS) is a form of orthostatic intolerance (OI). Its clinical signs such as dizziness and hypotension may mimic symptoms of adrenal insufficiency...

Introduction: Acromegaly is a disorder caused by excessive secretion of growth hormone, often due to pituitary masses. The first step in treatment is transsphenoidal surgery. Cabergoline, somatostatin receptor ligands or pegvisomant may be used in patients with an inadequate response after surgery. Finally, radiotherapy may be used in patients with inadequate response to medical treatment.Methods: In this retrospective study, data of 89 patients (59 fema...