Searchable abstracts of presentations at key conferences in endocrinology

ea0085oc9.8 | Oral Communications 9 | BSPED2022

Cyclic improvement of a structured education programme teaching dynamic glucose management strategies in children and young people with type 1 diabetes using continuous glucose monitoring

S Pemberton John , P Dias Renuka , Barrett Timothy G , Kershaw Melanie , Krone Ruth , Suma Uday

Background: In 2019, funding for continuous glucose monitoring (CGM) commenced for children and young people with diabetes (CYPD) in our region. However, there was no local established CGM structured education programme. We developed ‘the CGM Academy’ with continuous improvement using the Plan-Do-Study-Act (PDSA) cycle.Objectives: To review the PDSA cycle of improvements to deliver structured education using CGM.Methods: ...

ea0085p61 | Diabetes 3 | BSPED2022

GAME-SET-MATCH mnemonic: an infographic to teach effective dynamic glucose management strategies improving time in range in children with type 1 diabetes using continuous glucose monitoring

Pemberton John S , Dias Renuka P , Barrett Timothy G , Kershaw Melanie , Krone Ruth , Uday Suma

Background: Continuous Glucose Monitoring (CGM) is now becoming the standard of care for children and young people with diabetes (CYPD). Due to a lack of validated education programmes, we created ‘The CGM Academy’ delivering evidence-based structured education. The results of the first 50 CYPD graduating from the academy demonstrated statistically significant improvement in time in range (TIR, 3.9-10.0 mmol/l) by 8.3% (P<0.001) and HbA1c by 3.8 mmol/mol...

ea0058oc7.5 | Oral Communications 7 | BSPED2018

Diabetes control is worse in children and young people with type 1 diabetes requiring interpreter support

Idkowiak Jan , Elhag Sabba , Saraff Vrinda , Dias Renuka , Barrett Timothy , Kershaw Melanie , Krone Ruth

Introduction: Language barriers can pose a significant barrier to successful education of children and young people (CYP) with type 1 diabetes (T1DM) and their families, potentially influencing their glycaemic control.Methods: Retrospective analysis from diagnosis to 18 months post diagnosis of glycaemic control in 41 CYP with T1DM requiring interpreter support (INT) under care of our diabetes centre based within a multi-ethnic community. Median HbA1c at...

ea0033p45 | (1) | BSPED2013

Local factors influencing service improvements in median HbA1c in children and young people with diabetes between 2003 and 2012

Kershaw Melanie , Krone Ruth E , Krone Nils , Hogler Wolfgang , Shaw Nicholas , Kirk Jeremy , Barrett Timothy

Background: HbA1c is a marker for the risk of long-term complications of Diabetes. Our unit cares for 349 children and young people (CYP) from a population with a higher than average prevalence of low-income families, ethnic minority families, and high unemployment. Over the last 10 years there have been service improvements, increased resources and changes in practice.Aims: To review HbA1c outcomes achieved annually from 2003, compared with published na...

ea0030oc4.4 | Oral Communications 4 | BSPED2012

Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 protein, which regulates its stability and expression

Gharanei Seley , Zatyka Malgorzata , Astuti Dewi , Fenton Janine , Sik Attila , Nagy Zsuzsanna , Barrett Timothy

Wolfram syndrome is an autosomal recessive disorder characterised by neurodegeneration and diabetes mellitus. The gene responsible for the syndrome (WFS1) encodes an endoplasmic reticulum (ER) resident transmembrane protein, that also localises to secretory granules in pancreatic β cells. Although its precise functions are unknown, WFS1 protein deficiency affects the unfolded protein response, intracellular ion homeostasis, cell cycle progression, and granular acidificati...

ea0013oc34 | British Thyroid Association Award | SFEBES2007

Monocarboxylate transporter 8 (MCT8) represses proliferation of fetal embryonal NT2 and placental JEG-3 cells in vitro

James Sally , McCabe Christopher , Reaves Barbara , Smith Vicki , Chan Shiao , Barrett Timothy , Kilby Mark , Franklyn Jayne

Thyroid hormones play vital roles in fetal brain development. Mutations in MCT8, recently recognised as a specific thyroid hormone transporter, define a novel syndrome of severe X-linked psychomotor retardation and thyroid hormone resistance.N-TERA-2 (NT2) cells (human embryonal cells with characteristics of CNS precursors) were transiently transfected with either WT MCT8 or its L471P, R271H or S448X mutations, described in males affected by severe psych...

ea0045p36 | Diabetes | BSPED2016

A critical review of type 1 diabetes new patient education programme at a single tertiary centre

Uday Suma , Avann Charlotte , Barrett Timothy , Dias Renuka , Drummond Lesley , Kershaw Melanie , Krone Ruth

Introduction: Good patient education is the key to successful self-management of diabetes. In October 2013, we introduced a revised and extended ‘Newly Diagnosed Patient Education Programme’ involving 20 structured education sessions delivered by the multidisciplinary team.Aim: To assess the effect of the new patient education programme on HbA1c at the end of two years and compare this to a control group undergoing the old education programme.<...

ea0051oc7.1 | Oral Communications 7 | BSPED2017

JUMP: Maternal family history of diabetes and non-white ethnicity adversely affects beta cell response in young people with Type 2 Diabetes

Dias Renuka , Aston Kayleigh , tornese gianluca , Dunger David , Wales Jerry , Hamilton-Shield Julian , Barnett Anthony , Barrett Timothy

Background: Type 2 diabetes (T2D) in children and adults continues to rise. The relative contribution of pancreatic beta cell failure is not established. We aimed to analyse beta cell function in a subgroup of the UK T2D (JUMP) cohort.Methods: Participants were recruited at 58 hospital centres across England and Wales (n=204). Patients were 5–18 years, diagnosed with T2D (ADA criteria) and a BMI SDS>+1.0. At baseline, demographics, clin...

ea0044oc4.1 | Adrenal and Steroids | SFEBES2016

Novel brain biomarkers of cognitive abnormalities identified in patients with congenital adrenal hyperplasia

Webb Emma A , Elliott Lucy , Carlin Dominic , Hall Kirsty , Barrett Timothy , Salwani Vijay , Arlt Wiebke , Krone Nils , Peet Andrew , Wood Amanda

Background: Management of patients with CAH remains challenging. There is increasing evidence to suggest that failure to optimize treatment during childhood not only affects final height but also leads to psychological and psychiatric problems. Previous qualitative structural T2-weighted MRI studies have identified white matter hyper-intensities in up to 46% of CAH patients. The nature and functional relevance of these abnormalities remains unknown.Objec...

ea0058p050 | Diabetes | BSPED2018

A survey of the use of medical identification in children and young people with diabetes at a large children’s hospital

Yorke Jessica , Drummond Lesley , Collins Louise , Sands Donna , Krone Ruth , Saraff Vrinda , Dias Renuka , Barrett Timothy , Kershaw Melanie

Objectives: Children and young people (CYP) with Type 1 Diabetes Mellitus (T1DM) are at risk of acute clinical emergencies. Wearing medical identification (ID) is recommended by the National Institute for Clinical excellence (NICE). Information on adherence to this recommendation in CYP with T1DM is scarce. This study aimed to assess parent and CYP’s knowledge of the recommendation, to explore adherence and barriers to carrying ID and understand preferred forms of ID....