Endocrine Abstracts

Introduction: The number of patients with diabetes has been increasing at an alarming pace for the last decade. Sexuality is frequently affected in diabetic patients.The aim of this study was to describe the clinical profile of a group of type 2 diabetic patients suffering of erectile dysfunction (ED).Methodology: This was a cross-sectional study involving a population of 70 type 2 diabetic patients recruited from the day hospital ...

A 34-year-old male with two decades of gender identity issues considered gender reassignment and attended pre-orchidectomy sperm-banking when he was found to be azoospermic. He described a history of difficulty learning to play the piano and of deep-vein thrombosis at 19 years. He was 187 cm tall with a span of 189.7 cm, and exhibited L-sided undescended testis, R testis 1.8×2.5×3.7 cm, bilateral prominent gynaecomastia, a female body habitus, micropenis, bimanual sy...

Introduction: The prevalence of diabetes increases during cirrhosis resulting from a significant alteration in carbohydrate metabolism modifying the management of diabetes and worsening the liver prognosis. The aim of this work is to determine the prevalence of diabetes during cirrhosis, and to assess its prognostic impact on the disease.Material and method: this is a study collecting all cirrhotics followed in the gastroenterology department over a peri...

Introduction: Cryptogenic cirrhosis is cirrhosis that remains of unknown etiology after an exhaustive investigation. The relationship of cryptogenic cirrhosis with metabolic syndrome is strongly suggested. The aim of this work was to study the clinical-progressive profile of cryptogenetic cirrhosis and to determine the frequency of the metabolic syndrome.Patients and Methods: This is a study collecting all cirrhotic patients over a period of 4 years in o...

Background: Spondyloarthritis is a chronic inflammatory rheumatic disease which may be associated with different comorbidities such as glucose intolerance.Objectives: Determine the frequency of impaired fasting glucose in a population of patients with spondyloarthritis.Methods: We performed a cross-sectional study including 50 patients with spondyloarthritis (SA) diagnosed according to ASAS criteria. Fasting glucose was measured fo...

Introduction: Pseudoxanthoma elasticum (PXE), a multisystem heritable disorder, is characterized by ectopic mineralization of soft connective tissues. It is an autosomal recessive disorder in which mutations in the ABCC6 gene result in low levels of inorganic pyrophosphate (PPi).In its classic form, PXE is a late-onset, slowly progressing disease, and the major clinical problems relate to development of vascular complications, including hypertension, int...

Background: Acute adrenal insufficiency is a life threatening condition. Signs and symptoms are often non-specific. The adrenal gland has the richest arterial supply of any tissue with limited venous drainage and this mismatch predisposes to haemorrhagic infarction. We present a case report of acute adrenal insufficiency due to bilateral adrenal haemorrhagic infarcts associated with an open ankle fracture.Case history: A 52-year man fell from a ladder su...

Introduction: Endocrinologic dysfunction is a well-known complication after hematopoietic stem cell transplantation (HSCT) in children. The mechanisms of thyroid damage developing after transplantation remain not completely recognized. Toxicity of the conditioning regimen, especially total body irradiation, is most commonly postulated cause of endocrine abnormalities; immunological mechanisms (e.g. graft vs host disease) may also contribute to thyroid dysfunction.<p class=...

Introduction: We have recently described a preformed signalosome associated with the GnRH receptor (GnRHR), which undergoes dynamic rearrangement upon stimulation with GnRH. This signaling complex included c-Src, focal adhesion kinase (FAK), paxillin, vinculin, tubulin, caveolin-1, protein kinase C (PKC) δ, PKCε, PKCα, Ras, kinase suppressor of Ras-1 (KSR), MAPK kinase (MEK) 1/2, ERK1/2 and the GnRHR. To sort out the role of the signalosomes associated with the ...

The aim of the present research was to assess changes in the degree of peripheral blood (PB) lymphocyte apoptosis during methimazole treatment in the group of teenage children.Material and methods: The percentage of PB apoptotic lymphocytes, assessed by the decrease in mitochondrial transmembrane potential (CMXRos staining), was measured in 30 adolescents at the time of diagnosis, as well as after receiving the normalization of the thyroid hormones level...