Endocrine Abstracts

Background: Hypothyroidism is associated with multiple heart diseases such as tricuspid regurgitation (TR). We aimed to investigate in the prognosis of TR induced by hypothyroidism.Methods: We conducted a cohort study included all patients with severe primary TR. Long term prognosis of TR induced by hypothyroidism was compared to the prognosis of other severe primary TR causes.Results: Among 43 patients with severe primary TR, 19 p...

Introduction: The XX male syndrome occurs in 1 in 20,000 births. This syndrome results from crossover between the X and Y chromosomes, which transfers the sex-determining region of the Y chromosome to the X chromosome. They lack the azoospermia factor region of the Y chromosome, which is essential for spermatogenesis; thus causing infertility.Case Description: 34-year-old gentleman was referred to endocrinology clinic for infertility and semen analysis s...

Introduction: Gestational Diabetes Mellitus (GDM) in a common endocrinopathy during pregnancy. Anectodal evidence suggests that nutritional management of patients with gestational diabetes may reduce the risk of complications. Therefore, the aim of our study were, to assess eating habits in a population of pregnant women with GDM.Methods: It was a prospective study about 120 pregnant women with gestational diabetes recruited at the Diabetes and Pregnancy...

Case history: A 52 year old lady presented to her GP with a 2 year history of headaches, anxiety and loose stools. The GP found lid retraction and fine tremor but no goitre. Her heart rate was 100. Her GP sent blood for thyroid function tests and results showed a TSH of <0.03 mu/l and free T3 of >30.8 pmol/l. She was started on propranolol 40mg thrice daily and referred to endocrinology. In clinic she described palpitations whilst watching TV and sweatiness. She had su...

Introduction: Acromegaly is a quite rare and insidious disease caused by the oversecretion of growth hormone and subsequently insulin - like growth factor 1. Recent studies have demonstrated an increased co-existence of different thyroid lesions with acromegaly. However the data concerning this co-occurrence remains a matter of debate. The purpose of this study is to shed light on the different thyroid lesions concerning the patients with acromegaly who are followed up in the ...

Introduction: Maturity Onset Diabetes of the Young (MODY) is a monogenic form of non-insulin-dependent diabetes that classically presents in a lean individual with non ketotic hyperglycaemia and an autosomal dominant inheritance pattern. The diagnosis remains a challenge and may be made by careful clinical evaluation, but exact sub-typing is possible only by genetic analysis.Materials and methods: This is a prospective data analysis in the diabetology-en...

The definitive treatment for Cushing’s disease is curative surgery. Patients with severe disease burden will likely require pre-operative medical blockade to reduce the risk of peri- and post-operative complications. The threshold for deciding when to medically block excess cortisol is currently based on clinical judgment. Expert centres may use a different criteria to determine this. There is no widely adopted tool for evaluating the clinical severity of Cushing’s d...

Introduction: CSII is considered to be a more comfortable therapy and provide the best glycemic control. However, studies concerning of the long-term effects of pump therapy yield conflicting results, some of them reported beneficial long-term effect on metabolic control (reduction of HbA1c), whilst others have shown effects for a short period of time, not exceeded 1 year.The aim of the study was evaluation of the long-term effect of insulin pump therapy...

Introduction: The advent of insulin analogs has significantly reduced the undesirable effects of human insulin, particularly hypoglycemia. Beneficial effects on the lipid balance have also been described. The aimof our study was to describe the evolution of the lipidic parameters after the switch on insulin analogs.Patients and Methods: This is a longitudinal retrospective study about 61 patients with type 2 diabetes, switched to insulin analogs since at...

Introduction: Hepatocyte nuclear factor 1A MODY (HNF1A-MODY) is the most common form of Maturity-onset diabetes of the young (MODY) diagnosed in adults. It is caused by heterozygous mutations in the HNF1A gene and is associated with progressive β-cell failure and increasing hyperglycemia due to reduced insulin secretion. HNF1A-MODY is characterized by a large phenotypic variability. We herein report the case of a 40-year-old diabetic woman who was identified as h...