Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep983 | Thyroid (non-cancer) | ECE2015

Insulin resistance and low folate levels are associated with hyperthyroidism in Graves' disease

Neves Celestino , Esteves Cesar , Neves Joao Sergio , Sokhatska Oksana , Pereira Miguel , Palmares Carmo , Dias Camila , Carvalho Davide , Delgado Luis , Medina Jose Luis

Objective: To evaluate the interrelationships between thyroid function, insulin resistance, lipid profile, homocysteine, C-reactive protein (CRP), folic acid, and vitamin B12 levels, in Graves’ disease (GD).Methods: We recorded thyroid function tests, BMI, insulin resistance markers, lipid profile, homocysteine, CRP, folic acid, and vitamin B12 levels, in 104 subjects with GD in the first cycle of treatment with methimazole, 94% of whom were female....

ea0070aep911 | Thyroid | ECE2020

Insulin resistance, lipid profile and low-grade inflammation in Hashimoto thyroiditis

Afonso Marta , Neves Celestino , Sérgio Neves João , Pereira Miguel , Luís Medina José , Delgado Luís , Carvalho Davide

Background: Hashimoto thyroiditis (HT) is the most common autoimmune disease and patients may present different levels of thyroid dysfunction. The association between hypothyroidism and cardiovascular events is well established. However, it remains unclear how mild thyroid dysfunction, autoimmunity and chronic inflammation in HT contribute to an increased cardiovascular risk in euthyroid patients and in subclinical hypothyrodism. Therefore, this study aims to assess insulin re...

ea0070ep385 | Reproductive and Developmental Endocrinology | ECE2020

Hyperandrogenism caused by a leydig cell tumor of the ovary: A case report

Mendonça Fernando , Souto Selma , Magalhães Daniela , Fernandes Ana Sofia , Coelho Ana Rita , Portugal Raquel , Falcão Vera , Tavares Sara , Beires Jorge , Carvalho Davide

Introduction: Leydig stromal cell tumors are a subtype of steroid tumors that make up to less than 0.1% of the ovarian tumors. These neoplasms can affect women from all ages but are more frequent after menopause, being usually unilateral, benign and small sized. In around 75% of cases, these tumors produce androgenic hormones, causing oligomenorrhea and virilization.Case report: A 39-year-old woman, nulligravid, with complains regarding androgenic alopec...

ea0032p717 | Neuroendocrinology | ECE2013

Craniopharyngioma – a diagnosis not to be missed

Nunes Joana Menezes , Rodrigues Elisabete , Salvador Sergio , Cerejo Antonio , Reis Ricardo , Silva Sergio , Augusto Luis , Guimaraes Marcos , Vaz Rui , Carvalho Davide

Introduction: Craniopharyngiomas are intracranial tumors that develop from Rathke’s pouch rests of epithelium. They have a bimodal age distribution, with peak incidence at childhood and in the adult/elderly, although in our series we have more patients in a middle peak. Usually they are benign but responsible for significant morbidity, particularly when located near critical structures such as optic chiasm, pituitary gland and hypothalamus, and thus might cause visual, ne...

ea0032p1045 | Thyroid (non-cancer) | ECE2013

Graves' disease and cardiovascular risk factors

Brandao Carla , Neves Celestino , Palmares Carmo , Sokhatska Oksana , Esteves Cesar , Dias Camila , Pereira Miguel , Delgado Luis , Carvalho Davide , Medina Jose Luis

Objective: To evaluate the interrelationships between Graves’ disease (GD) and cardiovascular risk factors.Subjects and methods: We analyzed thyroid function tests, anti-thyroid antibodies, BMI, insulin resistance markers, namely homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body insulin sensitivity index (WBISI), in...

ea0026p403 | Thyroid (non cancer) | ECE2011

Thyroid nodules in children: review of 67 patients

Mesquita J , Lima S Paco , Matos M J , Neiva F , Pauperio S , Martins S , Costa C , Correia C Castro , Carvalho Davide , Fontoura Manuel

Introduction: Thyroid nodules in children and adolescents are less prevalent, but entail greater risk of malignancy than in adults. Most are asymptomatic because they are associated with normal thyroid function, but their prevalence is increasing due to the incidental diagnosis by neck ultrasound.Aims: To evaluate the characteristics of a pediatric population with thyroid nodules submitted to fine-needle aspiration (FNA) biopsy.Met...

ea0026p632 | Clinical case reports | ECE2011

Diagnosis of Bruns–Garland syndrome in a patient with McArdle disease and type 2 diabetes mellitus

Martins Raquel , Neves Celestino , Vaz-da-Silva Manuel , Rodrigues Pedro , Belo Sandra , Jorge Georgina , Magalhaes Angela , Castedo Jose Luis , Carvalho Davide

Introduction: McArdle disease is a rare recessive disorder of glycogen metabolism, related to muscle phosphorylase deficiency. It usually presents in adolescence or early adulthood with muscle cramps, exercise intolerance, easy fatigability, and progressive weakness as glycogen is the primary source of energy for intense muscle activity. Few reports described the association of McArdle disease and type 2 diabetes and some authors suggested that hyperglicemia and hyperinsulinem...

ea0022p433 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Pituitary adenoma mimicking a psychiatric disorder – a case report

Mesquita Joana , Joao Matos Maria , Varela Ana , Vinha Eduardo , Braga Daniel , Guerra Fernanda , Pereira Josue , Ayres Bastos Margarida , Castro Ligia , Carvalho Davide , Luis Medina Jose

Introduction: People with intracranial organic lesions, including pituitary tumours, may manifest initially as a psychiatric disorder, such as depression, emotional disturbance, anxiety, apathy, neurobehavioral disturbance, cognitive dysfunction and personality disturbance.Case Report: A male patient 45 years old was sent to the Department of Endocrinology of São João Hospital due to a pituitary macroadenoma. The patient referred asthenia, musc...

ea0022p775 | Thyroid | ECE2010

Insulin resistance, lipid profile, C-reactive protein and homocysteine in patients with autoimmune thyroiditis and subclinical hypothyroidism

Neves Celestino , Alves Marta , Carvalho Ema , Pimentel Isolina , Pereira Miguel , Ramalho Renata , Palmares Carmo , Guimaraes Cristina , Ramos Joao , Carvalho Davide , Delgado Luis , Luis Medina Jose

Background: Thyroid function, insulin resistance, serum lipid, C-reactive protein (CRP) and homocysteine are associated with an increased cardiovascular risk in patients with autoimmune thyroiditis (AIT).Objective: To evaluate the interrelations between thyroid function, insulin resistance, serum lipid concentrations, CRP and homocysteine in patients with AIT and subclinical hypothyroidism.Subjects and methods: We recorded thyroid ...

ea0022p824 | Thyroid | ECE2010

Evaluation of interrelationships between thyroid function, insulin resistance, lipid profile and inflammation in autoimmune thyroiditis

Neves Celestino , Alves Marta , Pereira Miguel , Pimentel Isolina , Carvalho Ema , Ramalho Renata , Palmares Carmo , Guimaraes Cristina , Ramos Joao Pedro , Carvalho Davide , Delgado Luis , Medina Jose Luis

Background: Autoimmune thyroiditis (AIT) is associated with increased risk of cardiovascular disease.Objective: To evaluate the interrelationships between insulin resistance (IR) and other cardiovascular risk factors, such as high sensitivity CRP (C reactive protein) and homocysteine in patients with AIT.Patients and methods: We analysed thyroid function, anti-thyroid antibodies, BMI, indices of IR, such as HOMA-IR, HISI (Hepatic I...