Endocrine Abstracts

Introduction: Gastroparesis associated with diabetic autonomic neuropathy is an underdiagnosed complication, although relatively common in diabetes. It is more prevalent in type 1 Diabetes Mellitus (DM1) with more than ten years of disease and especially in patients with poor metabolic control.Clinical case: Female, 37 years old, DM1 with 17 years of evolution with poor metabolic control (HbA1c 9.3%) and several microvascular complications such as prolif...

Background: Quality of life (QoL) has been variously reported as normal or impaired in congenital adrenal hyperplasia (CAH) adults. We found impaired QoL in UK CAH adults (Arlt et al. Journal of Clinical Endocrinology and Metabolism 2010 95 5110–5121) and now report the relationship between QoL (SF-36) and health outcomes in these patients.Methods: Cross-sectional analysis of 151 CAH adults with 21-hydroxylase defi...

Metabolic syndrome (MetS) is a condition characterized by abdominal obesity, insulin resistance, dyslipidaemia and hypertension, that is associated with cardiovascular disease and inflammatory metabolic disorders. This study aimed to ascertain the effect of selected parameters of purinergic and cholinergic systems in lymphocytes of MetS patients. The adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV) and acetylcholinesterase (AChE) activities, as well as γ-glutam...

Introduction: The antitumor activity of a novel cyclic amide, CLM94, with anti-VEGFR-2 and antiangiogenic activity, in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo, has been studied.Design and Methods: CLM94 was tested: i) in two human cell lines (HMVEC-d, dermal microvascular endothelial cells; 8305C, undifferentiated thyroid cancer) at 0.001–100 mcM; ii) in ATC cells at the concentrations of 10, 30, 50 mcM; iii)...

The molecular basis of parathyroid tumorigenesis has increased greatly over the last years and the variety of described abnormalities suggests different genetic defects leading to dysfunction of parathyroid cells. Using a combined approach based on two-dimensional electrophoresis (2DE) and mass spectrometry (MS) we performed a comparative proteome analysis to examine the global changes of parathyroid adenoma tissues protein profile with respect to the normal parathyroid tissue...

Childhood obesity and its later progression to Type 2 Diabetes (T2DM) are known to be associated with sub-clinical inflammation; although the underlying cause for this is unclear. However, studies suggest that bacterial endotoxin (LPS) derived from commensal bacteria in the human gastrointestinal tract may contribute directly to sub-clinical inflammation. Human adipose tissue expresses toll like receptors that induce an inflammatory cascade in the presence of endotoxin. Hence,...

Background: Mitotane,(o,p’-DDD)is a compound with potent adrenotoxic effect and is able to block cortisol synthesis by inhibiting 11β-hydroxylation and cholesterol chain cleavage. For these reasons, mitotane was widely used in the treatment of adrenocortical cancer. Nevertheless the biological mechanism induced by these treatments in this cancer cells remain unknown.Aim: To study whether the o,p’-DDD could increase the susceptibility to th...

Anti-Mullerian hormone (AMH) is expressed in the ovary, in granulosa cells (GC) of preantral and antral follicles. Mice lacking the AMH gene show an increase in the proportion of early growing follicles and a reciprocal decrease in the primordial pool, suggesting an important role in early follicle growth. Little is known about the expression of AMH in the human ovary. Recent studies have shown that the proportion of follicles entering the growing pool is increased in PCO, sim...

Background: Gastric Bypass surgery (Bypass) is recognized as the ultimate metabolic surgery. The success in type 2 Diabetes (DM2) remission documented in patients submitted to Vertical Sleeve Gastrectomy (Sleeve) made questionable the hypothesis that this restrictive surgery has beneficial metabolic effects.Main goal: Comparing the Bypass and Sleeve’s efficacy in DM2 remission.Methods: Retrospective study of 112 diabetic patie...

BackgroundThe pathophysiology of primary polydipsia, a disorder with increased fluid intake, is poorly understood. A dysregulation in the hypothalamic-pituitary-adrenal axis (HPA) is speculated and arises mainly from research in patients witch a schizophrenia spectrum disorder but data is contradictory. The aim of this study was to investigate markers of HPA axis activity in patients with primary polydipsia compared to healthy controls.<p class="abst...