Endocrine Abstracts

Background: Guidelines suggest treating paraphilias with androgen-deprivation therapy (ADT). However little evidence is available about the long-term impact on bone and how to manage this adverse event.Aim: The aim of this study is to assess the impact of ADT on bone mass and bone mineral density (BMD) in men treated for hypersexuality with cyproterone acetate (CPA) and GnRH agonists (GnRHa), and to evaluate the effect of treatment with bisphosphonates.<...

Background: In patients with type 1 diabetes (T1D), arterial stiffness is a potential alternative biomarker for cardiovascular (CV) risk as it has recently shown important prognostic value in the development of CVD that is independent from traditional risk factors. Glycemic control by means of HbA1c is a main determinant of arterial stiffness progression, however the relationship with continuous glucose monitoring (CGM)-derived parameters such as time in range (TIR) has not be...

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...

Background: While pituitary adenomas are the commonest Sella neoplasm, number of other entities should be considered in the differential diagnosis and the diagnosis is based on histopathological and immunohistochemical characteristics. Pituitary tumors with papillary architecture are uncommon and have limited differential diagnoses. Primary papillary epithelial tumor of the pituitary is a recently described histopathological entity with striking papillary architecture and TTF1...

Introduction: Intraportal (IP) islet cell transplants can restore metabolic control in type 1 diabetes patients, but limitations raise the need for establishing a functional beta cell mass (FBM) in a confined extrahepatic site.Methods: This study reports on function and composition of omental (OM) implants after placement of islet cell grafts with similar beta cell mass as in our IP-protocol (2–5.106 beta cells/kg body weight)<p class...

EEC is a multisystemic disease secondary to a clonal histiocyte proliferation of non-Langerhans cells due to hyperactivation of the MAPK/ERK signaling pathway, with somatic BRAF V600E mutation present in 50% of cases with therapeutic implications. Between 50% of patients develop endocrinopathies, the most frequent being central diabetes insipidus (CDI). We present the case of a 42-year-old woman, diagnosed with CDI in 1998 without family history, treated with DDAVP [MRI: absen...

The ingestion of marine foods is a potential route of contamination by tributyltin (TBT), a biocide organotin used as an antifouling in boat paints. TBT causes a phenomenon known as imposex, that induces, for instance, the irreversible appearance of male sexual characteristics in gastropod females. In mammals, TBT also directly impairs the sexual development. In fact, it is known that TBT can affect women in reproductive age. Our aim was to study whether the maternal exposure ...

Introduction: Adrenal incidentalomas are a frequent finding (1.4-7.3% on abdominal CT) and increasingly common with age, obesity, diabetes and hypertension. When approaching adrenal masses, clinicians should exclude malignancy and hormonal hypersecretion. Black adrenal adenomas (BAA), first reported in 1938, are rare benign adrenocortical tumours with black/brown appearance, containing lipofuscin. Most are non-functional, rarely inducing hypercortisolism. We present a case of ...

Introduction: Diabetes mellitus (DM) results from a defect in insulin secretion and/or its action. The Breast-Cancer Susceptibility Gene 2 (BRCA2), like BRCA1, is a tumour suppressor gene, and its mutation is associated with an increased risk of breast cancer and, in males, testicular cancer. In patients with the BRCA1/2 mutation, the level of Insulin-like Growth Factor (IGF)-1 and, consequently, the peripheral sensitivity to insulin are reduced, suggesting that this ...