Endocrine Abstracts

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Empty Sella (ES) represents a heterogeneous syndrome, with a completely unknown pathogenesis. Defects in the organogenesis or hypoplasia of the sellar diaphragm (associated with stable or intermittent variation of intracranial pressure and/or with pituitary volume variation) can facile the herniation of the arachnoid space into pituitary fossa and the consequently pituitary compression. ES can be the sequel of necrosis of pituitary adenomas, of hypophysitis or of brain/head tr...

Aims: Implementation of a protocol-driven, nurse-led clinic to see influence on cardiovascular risk and renal disease progression using a simple ‘ABC’ approach – target HbA1c <7%, BP <125/75 mm Hg and Cholesterol <4 mmol.Method: Weekly Diabetes Specialist Nurse (DSN) clinic with emphasis on ABC approach and guided FLORENCE Telehealth free texting technology for medication reminders and self-monitoring of BP (machines provided)....

Background: Social deprivation is high within our large ethnic and diabetes prevalent population. Compliance is a major stumbling block in the achievement of Blood Pressure (BP) targets. Given the above, we took the opportunity to enrol with West Midlands Academic Health Science Network (WMAHSN) Florence (Flo) Exemplar project mobile phone texting service. Flo sends advice and collects patient information which clinicians can access through any device connected to the internet...

Radiolabeled peptides that target with high affinity and specificity their receptors on tumor cells are being applied as nuclear tracers for both diagnostic imaging and targeted radionuclide therapy with great success. It is an extensive process to bring a newly designed radiolabelled peptide molecule from its design into the clinic however and from a vast number of newly designed and developed radiolabeled peptides only few will finally meet the conditions for clinical applic...

Glucocorticoid receptor (GR) agonists are amongst the most effective anti-inflammatory drugs available. These drugs are used in the treatment of a wide range of inflammatory and autoimmune diseases, and for the clinical management of cancer and organ/tissue transplantation. Unfortunately, the full clinical potential of these drugs has not been achieved, especially upon chronic use, due to the occurrence of side effects and/or resistance. The past years, most attention has focu...

Introduction: UK NICE guidelines recommend that men with diabetes mellitus (DM) should be reviewed annually regarding symptoms of erectile dysfunction (ED) in view of possible phosphodiesterase-5 (PDE-5) inhibitor treatment. Previous studies have shown that 70% of men with ED have concomitant lower urinary tract symptoms (LUTS). It has been suggested that there may be some common patho-physiology accounting for the improvement in LUTS seen in men with ED and LUTS treated with ...

Introduction: Peripheral diabetic neuropathic pain (PDNP) as a significant complication of diabetes mellitus (DM), which is present in 16–26% of patients. NICE UK guidelines recommend that physicians should make an formal enquiry about distressing neuropathic symptoms annually and that either duloxetine, amitriptyline, gabapentin, or pregabalin should be used as first-line treatment for neuropathic pain.Aims: To assess the prevalence PDNP in a diabe...

The most common testicular germ cell tumours (TGCT), seminoma or non-seminoma, occur in young adults and are derived from an intratubular precursor, carcinoma in situ testis (CIS). CIS cells display characteristics of developmentally arrested fetal gonocytes which during puberty acquire some features of more mature germ cells. Developing germ cells are under control of their somatic niche (Sertoli- and peri-tubular cells) and androgen-producing Leydig cells. A develop...

The physiological adaptations associated with energy deficiency contribute to menstrual cycle disturbances. The downstream effects of both energy deficiency and hypoestrogenism synergistically impair bone health, leading to low bone mineral density, compromised bone structure and microarchitecture, and ultimately, a decrease in bone strength. Low bone mineral density is frequently observed among exercising women and anorexic women with functional hypothalamic amenorrhea (FHA) ...