Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep628 | Pituitary and Neuroendocrinology | ECE2020

Safety and IGF-1 levels with once daily oral sst2 agonist paltusotine (CRN00808) in acromegaly patients previously treated with peptide long-acting somatostatin receptor ligands: Initial data from the open label ACROBAT Edge phase 2 study

Toth Miklos , Gordon Murray , Doknic Mirjana , Mezosi Emese , Randeva Harpal , Marmon Tonya , Fowler Kim , Luo Rosa , Monahan Michael , Madan Ajay , Ferrara-Cook Chris , Scott Struthers R. , Krasner Alan

Peptide long-acting somatostatin receptor ligands (SRLs) are a first line medical treatment for acromegaly but are not efficiently absorbed when delivered orally. Years of injections with SRLs are associated with variable dose delivery, injection site reactions, and excessive life burden. Paltusotine (CRN00808) is a nonpeptide small molecule somatostatin type 2 (sst2) receptor agonist with high oral bioavailability (70%) and a 42–50 hour terminal elimination half-life in...

ea0070aep737 | Pituitary and Neuroendocrinology | ECE2020

Body composition and bone mineral density in 107 patients with childhood onset growth hormone deficiency (CO-GHD) at the time of transition from pediatric to adulthood endocrine care

Doknic Mirjana , Stojanovic Marko , Milenkovic Tatjana , Zdravkovic Vera , Maja Jesic , Todorovic Sladjana , Katarina Mitrovic , Vukovic Rade , Miljic Dragana , Pekic Djurdjevic Sandra , Soldatovic Ivan , MilanPetako

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

ea0022p464 | Female reproduction | ECE2010

Kisspeptin levels in high risk pregnancies related to chronic diseases: insulin dependent diabetes mellitus (IDDM) and arterial hypertension (H)

Miljic Dragana , Cetkovic Aleksandar , Ljubic Aleksandar , Patterson Michael , Ghatei Mohammad , Bloom Steven , Djurovic Marina , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Popovic Vera

Objective: Kisspeptin is hormone involved in the initiation and maintenance of fertility. Placenta is the major source of kisspeptin but its role during gestation is still matter of debate. Studies investigating kisspeptin levels during gestation in patients with diabetes and hypertension are lacking. Our aim was to prospectively evaluate kisspeptin levels in pregnant women with chronic diseases such as IDDM and H.Design and methods: Kisspeptin levels we...

ea0022p558 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Clinically silent pituitary macroadenomas: a clinicopathologic analysis

Djurdjevic Sandra Pekic , Gazibara Milica Skender , Obradovic Angelina , Gacic E Manojlovic , Doknic Mirjana , Miljic Dragana , Djurovic Marina , Stojanovic Marko , Popovic Vera

Background: The so-called silent pituitary adenomas are a subtype of pituitary tumors showing positive immunoreactivity for one or more pituitary hormones, but without any clinical manifestations for oversecretion of these hormones. They are clinically labeled as non-functional pituitary adenomas (NFPA), some of them with particularly aggressive behavior. Rare patients might present with big plurihormonal pituitary tumors which ‘whisper’ hormones (GH or ACTH) and pro...

ea0016p396 | Neuroendocrinology | ECE2008

The effects of growth hormone deficiency following moderate and severe traumatic brain injury on cognitive functions

Stojanovic Marko , Pekic Sandra , Pavlovic Dragan , Zivkovic Vladimir , Djurovic Branko , Jovanovic Vladimir , Medic-Stojanoska Milica , Doknic Mirjana , Miljic Dragana , Djurovic Marina , Dieguez Carlos , Casanueva Felipe , Popovic Vera

Hypopituitarism, in particular growth hormone (GH) deficiency, is common among survivors of traumatic brain injury (TBI). We investigated neurobehavioral consequences of TBI-induced GH deficiency (GHD) in 61 patients (aged 37.7±1.7 years, 44 male/17 female) at least one year (mean, 3.9±0.6 years) after moderate and severe TBI (mean GCS score 10.6). All patients were tested with standard neuropsychological battery (MMSE, TMT, RAVLT, RCF, BNT and WCST for executive cog...

ea0014p225 | (1) | ECE2007

Changes in serum glucose metabolism and growth hormone, cortisol, prolactin, ghrelin, leptin concentrations in normal weight patients with schizophrenia before treatment with atypical antipsychotics

Doknic Mirjana , Maric Nadja , Pekic Sandra , Damjanovic Aleksandar , Miljic Dragana , Stojanovic Marko , Djurovic Marina , Jasovic-Gasic Miroslava , Dieguez Carlos , Casanueva Felipe , Popovic Vera

Schizophrenia is a devastating mental illness associated with obesity and diabetes mellitus rates that far exceed those of the general population.The aim was to evaluate changes in positive energy balance (serum insulin, leptin and ghrelin) and hormones involved in neuroendocrine regulations (serum cortisol, growth hormone and prolactin) before treatment with atypical antypsyhotics (SGA) in normal weight patients with schizophrenia.<p class="abstext"...

ea0014p546 | (1) | ECE2007

ACTH and cortisol responses to ghrelin and DDAVP in patients with Cushing’s disease (CD)

Miljic Dragana , Doknic Mirjana , Pekic Sandra , Djurovic Marina , Penezic Zorana , Damjanovic Svetozar , Macut Djuro , Sumarac-Dumanovic Mirjana , Popovic Bojana , Ghatei Mohammad , Popovic Vera

Aim of this study was to investigate head to head ACTH and cortisol responses to DDAVP and ghrelin in patients with CD. Study was approved by the local ethics committee and informed consent obtained. Nine patients with CD were submitted to ghrelin 1 μg/kg and DDAVP 10 μg bolus iv administration on two separate occasions. Blood was sampled at 0.15, 30, 45, 60, 90 min. for ACTH (ELISA) and cortisol (RIA, Cis, Bio International, France) measurements.<p class="abstex...

ea0056p91 | Clinical case reports - Pituitary/Adrenal | ECE2018

Intracerebral hemorrhage as a first sign of pheochromocytoma

Djurdjevic Sandra Pekic , Jovanovic Vladimir , Tasic Goran , Paunovic Ivan , Tatic Svetislav , Dundjerovic Dusko , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Jemuovic Zvezdana , Djurovic Marina Nikolic , Popovic Vera , Petakov Milan

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young. Few cases of these neuroendocrine tumors which presented with intracerebral hemorrhage have been reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He has a six months history of headache, palpitations and sweating. During examination he became somnolent and devel...

ea0056p748 | Neuroendocrinology | ECE2018

Metabolic status, body composition and bone mineral density in 85 patients with childhood onset growth hormone deficiency (COGHD) in transition period

Doknic Mirjana , Milenkovic Tatjana , Zdravkovic Vera , Jesic Maja , Todorovic Sladjana , Mitrovic Katarina , Vukovic Rade , Miljic Dragana , Pekic Sandra , Soldatovic Ivan , Stojanovic Marko , Petakov Milan

Transition from childhood to adulthood is particularly important in patients with COGHD mainly because of the associated metabolic abnormalities, inadequate body composition and decreased bone mineral density (BMD). There is a lack of large monocentric studies related to this issue.Design: Monocentric, observational, retrospective cross-sectional study.Patients: We collected 85 COGHD patients (58 males, aged 17–26 years) trans...

ea0073oc15.4 | Oral Communications 15: Late Breaking | ECE2021

Identification of a dose range for once daily oral paltusotine in patients with acromegaly that maintains IGF-1 levels when switching from long-acting somatostatin receptor ligand therapy

Gordon Murray B. , Gadelha Monica , Toth Miklos , Doknic Mirjana , Mezosi Emese , Randeva Harpal , Marmon Tonya , Luo Rosa , Monahan Michael , Madan Ajay , Struthers Scott , Krasner Alan

Long-acting somatostatin receptor ligands (LA-SRLs) are a first line medical treatment for acromegaly but require monthly parenteral administration. Paltusotine (CRN00808) is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability (70%), suitable for once daily, oral dosing. The recently reported results of the ACROBAT Edge study (NCT03789656) suggest that patients with acromegaly treated with injected SRLs can switch to once dai...