Endocrine Abstracts

In recent decades, a great deal of investigation has been focused on the role of gut hormones in energy homeostasis. The gastrointestinal tract is the largest endocrine organ in the body producing hormones that have important sensing and signalling roles in regulating body weight and energy expenditure. Dietary modifications are the first-line treatment for obesity however dieting results in only moderate weight-loss and maintenance of weight-loss is poor. Compensatory gut hor...

Background: 5-Hydroxyindoleacetic acid (5-HIAA) is the main metabolite of serotonin and is measured in all patients newly diagnosed with neuroendocrine tumours both to diagnose carcinoid syndrome and to monitor treatment response for those with an elevated baseline level. Each test requires patients to avoid certain foods and collect urine over a 24 hour period. It is not known to what extent patients adhere to these requirements or find them burdensome. There...

Introduction: Surgery is the only known curative therapy for lung/bronchial neuroendocrine tumours (NET). Factors that affect survival after surgery for lung NET are not clear, and hence follow up protocols are not evidence-based.Methods: We collected data on 318 prospective patients that were operated on at a single centre between 2012 and 2020 (Guys and St Thomas’s regional thoracic surgery unit). The aim was to g...

Purpose: To evaluate the added benefit and accuracy of [68Ga]Ga-DOTA-TATE PET/CT scans in detecting pancreatic neuroendocrine tumours, compared to conventional cross-sectional imaging with CT or MRI scans, in patients with multiple endocrine neoplasia type 1 (MEN1)Methods: A retrospective analysis was performed comparing the initial [68Ga]Ga-DOTA-TATE PET/CT to the respective contemporary CT or MRI ...

Introduction: Maintaining adequate nutritional status can be a challenge for patients with small intestinal neuroendocrine tumours (NETs) and mesenteric lymph node metastasis which can form a mesenteric mass. The preferred treatment option would be resection of this mesenteric mass, however, due to adjacent small bowel loops there is a risk of developing short bowel syndrome (SBS). If the mesenteric mass is not resected there is a risk of developing inoperable...

Background: The aim of study was to determine the effectiveness of Thyroid detoxification program therapy in patients of hypothyroidism, attending TATC clinic in Maharashtra. According to the clinical survey from various studies on thyroid disease, it has been estimated that about 32% of people suffer from thyroid diseases in India out of which 10.7 % of people have hypothyroidism. According to health experts, even though hypothyroidism is easy to detect and inexpensive to tre...

Ectopic parathyroid glands arise from aberrant migration during early stage of development. Lack of successful identification leads to failed parathyroid surgery and persistent hyperparathyroidism.Case History: A 57-year-old lady presented with abdominal discomfort and diffuse bone pain. Her corrected serum calcium was raised at 2.81mmol/l, reduced serum phosphate with an inappropriate intact PTH concentration of 10.5 pmol/l. Initial, vi...

Graves’ disease is the most common cause of hyperthyroidism. It is well established that hyperthyroidism promotes a hypermetabolic state characterized by increased resting energy expenditure, increased lipolysis and gluconeogenesis. We describe a rare complication of thyrotoxicosis in a patient with type II diabetes on insulin, with no previous thyroid history. An 83 year old woman with type 2 diabetes on biphasic insulin presented with symptoms of polyuria, polydipsia a...

BackgroundThe prevalence of type 2 diabetes has been increasing all over the world. Various risk factors have been identified for the generation of type 2 diabetes include; ageing, family history of diabetes, general obesity, central obesity, physical inactivity, and sedentary lifestyle. Obesity, particularly central obesity is associated with insulin resistance (IR), ’beta-cell’ dysfunction, partly through increased free fatty acids (FFAs) and...

Aim: Promoting cohesion, community and knowledge of diabetes through the co-production of a video exploring the social and clinical impact of attending a residential activity camp for children and families living with type 1 diabetesMethod: From our knowledge of attending previous diabetes camps, the video will begin by highlighting the background and motivation behind the study, emphasising the limited understanding of ...