Endocrine Abstracts

IntroductionThe main population of GnRH-1 neurons that control activity of the HPG axis in primates originate in the peripheral olfactory system. Recently, in vitro primary cell cultures from human fetal olfactory epithelium, named FNC-B4, have been shown to express GnRH-1 and are likely to be the precursor of the adult-like GnRH-1 system distribution in the CNS. A number of external and cell-autonomous factors are known to control migration of these spe...

IntroductionIn higher vertebrates, the main population of forebrain GnRH1 neurons originate in the embryonic olfactory placode. Early migration of GnRH neurons in mice - from the nasal placode into the nasal mesenchyme - depends on NELF (nasal embryonic LHRH factor). Furthermore, migratory GnRH cells express the leptin receptor. The precise role(s) of leptin during neuroendocrine GnRH development are unknown but it may combine with Neuropeptide Y (NPY) t...

The V600E mutation of BRAF oncogene is one of the most frequent genetic events in thyroid cancer, particularly in papillary thyroid carcinomas (PTC) and in some anaplastic carcinomas that derive from preexisting PTC. It has been associated with advanced clinical stages, extrathyroidal extension, and a high risk of recurrences, particularly those that have lost the ability to accumulate iodide, a property mediated by the sodium iodide symporter (NIS).Our ...

Introduction: Primary hyperparathyroidism (PHPT) is associated with increased risk of mortality from cardiovascular disease and this appears to decrease with time after parathyroidectomy. However, data on hyperparathyroid patients are conflicting and there is no data regarding secondary hyperparathyroid patients. Our aim in this study was to determine the association between flow-mediated dilatation (endothelium dependent, FMD), nitroglycerine-induced dilatation (endothelium i...

Introduction: Coagulation and fibrinolysis defects were reported in primary hyperparathyroid(PHPT) patients. However, there is not enough data regarding platelet functions in this group of patients. Platelet functions of hyperparathyroid patients were measured in very few studies and they have conflicting results. Our aim was to evaluate the platelet functions in primary and secondary hyperparathyroid(SHPT) patients and to compare it with the healthy subjects.<p class="abs...

Background: Among the lung carcinomas metastasizing to the thyroid, adenocarcinomas are the commonest followed by squamous, small cell, large cell and bronchioloalveolar carcinomas.Case presentation: A 55-year-old man who presented with superior vena cava syndrome was found to have an 11 cm mediastinal mass encasing superior vena cava and compressing trachea and esophagus. The mass reached right pulmonary hilus. A bronchoscopic biopsy showed small cell c...

Introduction: Primary and secondary hyperparathyroidism may coexist unrelated to chronic nephropathy. It can occur more often than expected, especially in elderly population with malabsorption syndrome or /and liver diseases.Case report: A women 60 years of age was admitted to hospital due to long standing ostealgia. The primary hyperparathyroidism was suspected. The medical history presented recently diagnosed coeliac disease and cryptogenic hepatic cir...

Introduction: The category of impaired fasting glucose (IFG) denotes a state of non-diabetic hyperglycemia, considered a risk factor of the further development of diabetes mellitus (DM) and cardiovascular (CV) diseases.Aim: The aim of the present study is to evaluate the impact of IFG on sexual health in men. In addition its effect on CV morbidity and mortality will also be addressed.Methods: A consecutive series of 3451 men (mean ...

Introduction: Higher cortisol levels and, in particular, hyperactivity of the HPA axis might play a role in the development of MS at least in adults. Data on the pediatric age are scanty.Aim of our study was to evaluate ACTH and cortisol association with MS, its components, phenotypic parameters, family history of metabolic derangements in pediatric obesity.Methods: Cross-sectional study. 271 Caucasian overweight or obese children ...

Introduction: The risk association between the insulin like growth factor-1 (IGF1) and cardiovascular risk is inconclusive in adults and under-explored in the pediatric population. We aimed to investigate the associations between serum concentrations of IGF1 and cardiovascular risk factors in obese children and adolescents.Methods: Cross-sectional study. Clinical and metabolic evaluations including an oral glucose tolerance test (OGTT) were performed at ...