Endocrine Abstracts

Introduction: Abnormalities of lipid metabolism and arterial hypertension occur with increased frequency in hypothyroidism and are associated with a higher risk of premature atherosclerotic vascular disease. Therefore, a vigorous lipid lowering treatment seems mandatory, including quickly restoration of thyroid function, to reduce vascular risk. We evaluate benefits on lipid profile after intravenous thyroxine treatment in severe hypothyroid patients at three and thirty days.<...

Introduction: Pituitary adenomas are considered to be benign tumors that are diagnosed by its sympthoms (secondary to compression or hormonal secretion) or incidentally in an imaging technique performed because of another reason. ‘Silent’ somatotrophinomas are very rare. This type of adenoma is typically large and despite it presents with mild or no acromegalic features it usually develops hormone secretion.A case report: A 29-year-old spanish ...

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Objectives: To analyze the prevalence of episodes of diabetic decompensation in patients admitted in Orthopedic Surgery and Traumatology (OST) area.Material and methods: Descriptive analysis of patients admitted to OST Service who presented abnormally high or decreased blood g...

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Objetives: To analyze the prevalence of episodes of diabetic decompensation in patients admitted to the area of Vascular Surgery and Angiology (VS).Material and methods: Descriptive analysis of patients admitted to the VS Service who presented abnormally high or decreased bloo...

Introduction: Stroke is the second cause of death in the world and the first cause of disability. It is also the second cause of Diabetes-related death. The success of reperfusion therapies is time-dependent, with most delays being patient-related. We investigated the response to stroke in diabetic patients (DM), as their risk of stroke is increased by 1,8-6 times.Material and Methods: Consecutive patients with acute stroke or transient ischemic attack w...

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase of maternal-fetal complications. Continuous glucose monitoring system (CGMS) detects postprandial hyperglycemia and hypoglycemia during 24 h.Methods: Women with GDM in gestational weeks 26–32 were allocated a CGMS (IproTM2) after diagnosis in an observational prospective study. It was analysed:- CGMS: Mean glucose and standard deviation...

Introduction: Rapid correction of hyponatremia is known to cause central pontine myelinolysis. It may concurrently involve other areas of brain as well, referred as extra-pontine myelinolysis (EPM). Isolated EPM however is a very rare occurrence. We present a case of EPM where the hyponatremia was secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) after surgery for a pituitary macroadenoma.Case report: A 36-year-old man underwe...

Abstract: A 14-yr-old male patient with acromegaly and TSH-induced hyperthyroidism is reported. He was referred for hormonal study due to clinical suspicion of acromegaly. Physical examination showed acromegalic/gigantism features (high stature: 194.5 cm (P>90), such as: abnormal growth of the hands and feet, furrowed forehead and pronounced brow ridge). No goiter was found. GH levels were high and were not suppressed after oral glucose (GH: 12.50 ng/ml, GH after ...

Introduction: Nivolumab is an anti-programmed cell death-1 monoclonal antibody approved for the treatment of metastatic malignant melanoma. Several endocrine disorders have been reported as immune-related adverse effects. However, nivolumab-induced hypophysitis has a lower incidence than ipililumab.Case report: A 69-years old man with metastatic melanoma started to receive nivolumab. Ten weeks after the first cycle of nivolumab he presented hyperthyroidi...

About 10–15% of prolactinomas (P) are resistant to Dopamine agonists (DA). We analyzed retrospectively ten resistant prolactinomas (RP) treated at our center between 1995 and 2014, to identify useful variables to predict DA resistance and its different patterns (biochemical resistance (BR), morphological resistance (MR) or both). BR is defined as the failure to normalize prolactin (PRL) levels with ≥ 2 mg/week of cabergoline (C) for at least 3 months. MR is consider...