Endocrine Abstracts

GPR83 is an orphan G-protein coupled receptor (GPCR) and is expressed in thymus and brain. Within the brain GPR83 mRNA is identified at high levels in the hypothalamic arcuate nucleus that is known to control for body weight regulation.Expression of GPR83 in the arcuate nucleus and the protection of GPR83 knock-out mice against diet induced obesity prompted us to investigate GPR83 signaling properties as well as potential interaction with the melanocorti...

Aim: Obesity prevalence increase fastly and become important health problem all around the world. Aim of our study to determine obesity and abdominal obesity prevalence in west black sea region and to display the prevalence of chronic diseases especially diabetes mellitus (DM) in obese population.Material and method: We evaluate 2222 (1418 female, 804 male, mean age 50) participant in Yigilca region. We took medical history and physical examination of al...

Rab proteins (Rab GTPase) have been implicated in the trafficking and exocytosis of secretary vesicle and play a central role in the secretion of hormones or neurotransmitters. However, the involvement of Rabs and Rab effectors in the regulation of AVP secretion is still unknown. Embryonic stem (ES) cells are pluripotent cells that differentiate into all cell types. Recently, it has been reported that when dissociated ES cells are quickly reaggregeted in low cell-adhesion cult...

Introduction: With the advancement of surgical techniques and equipments, many patients with acromegaly have achieved complete remission after surgery. Normalization of growth hormone (GH) brings about improvement of vital prognosis, but recovery from high GH hematologic disease induces various abnormalities. We focused on the body weight and body composition of the patients with acromegaly and examined the post-surgical changes.Materials and Methods: 19...

Introduction: Cigarette smoking is one of the most serious substance abuse problems. It is generally accepted that nicotine and other chemicals in tobacco smoke alter endocrine functions in men and adverse reproductive outcomes, including deterioration of sperm. Studies on the effects of smoking and smoking cessation on male sex hormones are inconsistent. We studied changes of hormonal levels in men during smoking cessation and we looked for a possible predictive marker of suc...

Introduction: According to the guideline for medical treatment of Graves’ disease by the Japan Thyroid Association in 2011, discontinuation of antithyroid drug is recommended when normal thyroid functions have been maintained for a certain period (≥6 months) after treatment with a minimum maintenance dose (mentioned below). We prospectively studied the remission rates in the patients with Graves’ disease.Methods: The subjects were 108 pat...

Objectives: Brain Derived Neurotrophic Factor (BDNF) plays a fundamental role in regulation of metabolism and energy homeostasis. Low BDNF levels have been identified as possible biological causes for development of obesity and BDNF administration has been shown to induce weight loss and to improve insulin sensitivity in diabetic animal models. Acute exercise is known to induce a transient increase of peripheral BDNF but no information is yet available regarding the exercise-i...

Background: Increased childhood cancer survival has resulted in an accruing adult cohort faced with potential infertility. Pre-treatment semen cryopreservation can protect reproductive capacity in adolescent minors, but continued unique legal, ethical and educational barriers prevent consistent service provision across the UK. The effect of pubertal maturation, disease and treatment on the ability to produce sperm also remains poorly defined in this cohort. We present our 10-y...

AMH causes regression of Müllerian ducts during male fetal development. Recently, AMH was detected in the adult ovary, principally in granulosa cells (GCs). Studies have demonstrated a 1.5–5 fold increase in serum AMH in women with PCOS compared to normal ovulatory women. The AMH rise was assumed to be secondary to increased numbers of follicles. Interestingly, the insulin sensitiser metformin, which is in widespread use in PCOS, caused a significant reduction in ser...

Aim: Sibutramine, orlistat and metformin appear beneficial for the treatment of adult with obesity. Several investigators have suggested that larger weight losses might be achieved by combining weight loss agents. The aim of this study was to compare the effectiveness of sibutramine monotherapy versus sibutramine plus metformin combination therapy in obese women with normal glucose tolerance.Material-method: This is a 6 month, prospective and randomized ...