Endocrine Abstracts

Aim : We compared the Hospital practice in the management of hyperthyroidism using radioiodine with the guidelines recommended by the working group of Royal College of Physicians and Society for Endocrinology. We also assessed the outcome of the treatment.Methods: All 51 consecutive patients (female - 47, male - 4) who had radioiodine treatment from Jan 1997 till Dec 1998 were included, among which 5 patients had two doses of radioiodine. All of them rec...

Aim : We compared the Hospital practice in the management of hyperthyroidism using radioiodine with the guidelines recommended by the working group of Royal College of Physicians and Society for Endocrinology. We also assessed the outcome of the treatment.Methods: All 51 consecutive patients (female - 47, male - 4) who had radioiodine treatment from Jan 1997 till Dec 1998 were included, among which 5 patients had two doses of radioiodine. All of them rec...

There is ample evidence that despite an overall improvement of iodine intake, not only in Germany but also in many European countries pregnant woman may be deficient of this trace element.Healthy pregnant women (n=66) without a thyroid history volunteered for an ultrasound scan of the thyroid and for a blood sample; TSH, free T ¾ and TPO - antibodies were measured of the thyroid.21 (32%) of the pregnant women exhibited an ...

Introduction: Radioiodine (RAI)-therapy for Graves’ disease (GD) is often followed by worsening autoimmunity, and the increase in TRAb may persist for several years. In pregnant women TRAb pass the placenta and may stimulate the fetal TSH receptor with a risk of fetal and neonatal hyperthyroidism.Case report: A 21-year old woman with GD was treated with RAI, and subsequently was euthyroid with L-T4-replacement. Before RAI-therapy, TRAb was 8 U/l (re...

Background: In the classic paradigm, the primary function of sex hormone-binding globulin (SHBG) was thought to passively bind and transport steroids and estrogens in the blood to access target tissues and to determine their bioavailable fraction. Now there is increasing evidence that SHBG plays an active role in steroid actions and is an actively contributes to many age-associated comorbidities including type 2 diabetes, obesity, and metabolic syndrome (MetS).<p class="ab...

Introduction: Follicle stimulating hormone receptors (FSHR) are physiologically expressed in gonads. FSHR are also expressed in gonadal cancers, but nothing is known on FSHR appearance in non-gonadal endocrine tumors. The present paper reports on the immunohistochemical detection of FSHR in pituitary, thyroid, adrenal and neuroendocrine tumors (NET).Materials and methods: The study included samples of 80 endocrine tumors (28 pituitary adenomas, 7 thyroid...

It is a widely accepted concept that G-protein-coupled receptors (GPCRs) are able to form homo- and heterodimers. The physiological relevance of these interactions is of utmost importance.Recently, we demonstrated that due to co-expression of two key players of hypothalamic body weight regulation, the melanocortin 3 receptor (MC3R) and ghrelin receptor (GHSR), signalling of the MC3R is enhanced (hyperstimulation) as compared to activation of MC3R alone. ...

Obesity is an important and chronic disease. It is known that obesity closely related with many chronic disorders.Also it is known as a result of serious morbidity and mortality. For treatment of obesity, dietary, medicine, egzercise and surgery should be useful but they have also some adverse effects and surgery should be cause of mortality and severe morbidity.Our method of EGB is completely non-invasive and we investigated the efficacy of obesity trea...

Objective: Although subclinical thyroid dysfunction is associated with cardiac endpoints such as endothelial dysfunction, left ventricular hypertrophy, thickened artery walls or atrial fibrillation, it is currently under debate whether subclinical hyper- or hypothyroidism as well as thyroid function within the reference range are associated with an increased risk of hypertension. So far no study investigated the association between thyroid function and blood pressure in childr...

Glucagon-like peptide-1 (GLP-1) is an incretin hormone playing an important role in glucose-dependent insulin secretion and β-cell growth. However, GLP-1 is rapidly degraded by dipeptidyl peptidase IV (DPP-IV) in vivo. Many attempts have been made to develop long-acting GLP-1 analogs with chemical modification, amino acid substitution, and fusion protein technology. We previously showed that the N-terminal Ala- or Gly-extended GLP-1 and human immunoglobulin ...