Endocrine Abstracts

Red blood cell (RBC) deformability is an ability of RBC to change shape under stress, and it has been known to be decreased in diabetes. However, the role of RBC deformability is not determined in type 2 diabetes (T2D) yet. We attempted to clarify whether RBC deformability is related with diabetic complications. This was a cross-sectional study, and 452 T2D patients were enrolled. RBC deformability was measured by using a microfluidic ektacytometer, Rheoscan-D (Rheo-Meditech, ...

Parathyroid carcinoma, a rare endocrine malignancy, accounting for only 1–2% of patients with primary hyperparathyroidism (HPT). In addition, a few case have been reported coexistence of parathyroid carcinoma and papillary thyroid cancer. Here, we present a case of recurred parathyroid cancer with multiple lymph node metastasis. A 57-year-old women was presented with high serum calcium level (14.4 mg/dl) in medical check-up. Hyperparathyroidism was considered to be the re...

Purpose: Aster spathulifolius Maxim is one of plants of chrysanthemum, which has shown an anti-obesity activity in diet induced mice model. We performed clinical trial for evaluating the anti-obesity efficacy and safety of Aster spathulifolius Maxim extract on obese human.Methods: This study was randomised, double-blind, placebo-controlled clinical trial in Korea. A total of 41 obese subjects (BMI 25–30 kg/m2) aged ≥20 years were ra...

Aims: Central obesity is associated with increased cardiovascular morbidity and mortality. It has been proposed that increased lipid accumulation in vascular tissue and the consequent increase in oxidative stress may be a missing link between obesity and atherosclerosis. The peroxisome proliferators-activated receptor (PPAR)-γ coactivator 1-α (PGC-1α) is a transcriptional coactivator playing an important role in energy metabolism. PGC-1α is present in vascu...

Background: Cortisol and growth hormone elevations are critical counterregulatory responses to severe hypoglycemia. However, the proportion and clinical characteristics of type 2 diabetic patients who fail to show appropriate cortisol and/or growth hormone secretion in response to severe hypoglycemia have not been investigated.Methods: We measured the plasma cortisol and growth hormone levels in type 2 diabetes with severe hypoglycemia (defined as blood ...

Few studies have investigated the intracellular signaling pathways mediating the effects of glucagon-like peptide-1 (GLP-1) secretagogues in enteroendocrine L cells. Specific receptors, channels, and intracellular signaling proteins expressed by the L cells have only begun to be characterized. The present study aimed to investigate the role of the olfactory receptor (OR) OR51E1 in GLP-1 secretion. We verified the expression of olfactory marker protein (OMP), an indicator of OR...

Olfactory marker protein (OMP) is a marker of olfactory receptor-mediated chemoreception, even outside the olfactory system. Here, we report that OMP expression in the pituitary gland plays a role in basal and thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) production and secretion. We found that OMP was expressed in human and rodent pituitary glands, especially in PRL-secreting lactotrophs. OMP knockdown in GH4 rat pituitary cells increased PRL production and secr...

Objectives: Prolactin (PRL) normalization after 3 months of Cabergoline (CAB) treatment are useful predictors of responsiveness in patients with prolactinoma. However, differences within the PRL normalization cut-off value have not been identified.Methods: We reviewed the medical records of patients with prolactinomas who were treated with CAB as a primary drug at Severance Hospital. We included patients who had a full dataset of pituitary hormone assays...

We present a case of a 62-year-old lady with a grade 3 well-differentiated metastatic gastric-neuroendocrine tumour complicated by symptoms of CS (weight-gain, bruising, proximal weakness) which developed over 4 weeks. She had progressive disease after exhausting all conventional anti-neoplastic therapeutic options. Screening tests revealed raised 24-h urinary free cortisol (3460 nmol/24h[<165]), post-overnight dexamethasone suppression serum cortisol (serF) 1200 nmol/l(&#...

Endocrine-Related Cancer, 2019, 27(2): 81–95 (DOI: https://doi.org/10.1530/ERC-19-0095)...