Endocrine Abstracts

Introduction: ROHHADNET syndrome is a newly described condition characterized by rapid-onset obesity, pulmonary hypoventilation, hythalamic, autonomic dysregulation and, neural tumors. The severity of the clinical manifestations can rapidly lead to death by cardiorespiratory arrest.Case report: We present the case of a 5.10 years old girl, who was admitted in the Endocrinology department for evaluation of a significant weight gain began 2.5 years ago.</p...

Background: Patients undergoing thyroid surgery are consented for a 1% risk of permanent hypocalcaemia and voice changes. These complications are considered to be permanent if they persist for more than 6 months. The aim of this study is to determine the incidence of complications in patients undergoing thyroid surgery in our hospital.Methods: From January 1999 to March 2009, all patients who underwent thyroid surgery under the care of one surgeon were i...

Introduction: Faster decline in serum thyroid hormone levels in hyperthyroidism is seen adding cholestyramine at conventional treatment in some studies (1.2).Design/methods: Retrospective controlled study. Follow-up: ±3 weeks.Patients with hyperthyroidism: 17 treated with antithyroid drugs (mean dose 35 mg/day) combined with cholestyramine (mean dose 12 g/day).Control group: 23 only treated with antithyr...

Objective: Increasing evidence suggests a role for mineral metabolism in cardio-vascular disease risk. We aimed at determining in type 2 diabetes patients the relationship between serum levels of 1–84 parathormone (PTH1–84), 25-hydroxy-vitamin D (25(OH)D) or calcium and the glycated hemoglobin (HbA1c), insulin sensitivity or β-cells function, but also the relationship between these factors and coronary arterial disease confirmed by myocardial scintigraphy.<p...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a benign disorder, with inappropriately elevated parathyroid hormone, without the complications of hypercalcemia (1). It is important to discriminate FHH from primary hyperparathyroidism (PHPT), because of the consequences on symptomatic disease and therapeutic approach. Ca/Cr clearance ratio will be <0.01 in FHH and most often >0.02 in PHPT (2). In patients with PHPT and vitamin D deficiency, low urinary calc...

Objective: Matrix γ-carboxyglutamate (Gla) protein (MGP) is a marker of athero-sclerosis reflecting the degree of inhibition of ongoing calcification processes in the vascular wall. Osteoprotegerin (OPG) and adiponectin (ADP) exerts anti-inflammatory and anti-atherosclerotic effects. We aimed at determining in type 2 diabetes patients the relationship between serum MGP, OPG, ADP levels and the HbA1c, HOMA insulin-sensitivity or B-cell function.Resea...

The family of calcium/calmodulin-dependent protein kinases (CaMK) are major effectors of calcium binding proteins in virtually all systems. Recently, CaMKs have been implicated in regulating pituitary and hypothalamic gene transcription to control the expression of gonadotrophin hormones and adrenocorticotrophin in the pituitary, and as a pivotal protein in the satiety pathway. Despite these observations, the spatial and temporal expression of the CaMKs is poorly documented an...

Pituitary hormones are released into the bloodstream in a pulsatile fashion in response to stimuli from their hypothalamic regulators. For efficient generation of hormone pulses, both the hypothalamic mechanisms and the pituitary target cells must exhibit a high degree of coordinated secretory activity. This is particularly important for the growth hormone (GH) axis since the target tissue responses are critically dependent on the temporal pattern of GH exposure, as well as th...

We observed 26 women from 19 to 40 years old (mean age 27) with hypogonadotropic hypogonadism (HH) due to different causes excluding prolactinomas. The continuance of HH was from 1 to 23 years (mean 6 years 4 months). Main complains were amenorrhea (all patients), urogenital disorders (18 patients), ingravescent memory and fatigue (17 patients). Biochemical blood test relieved increased cholesterol and high density lipoprotein levels in all patients, increased triglyceride lev...

BackgroundThe prevention of complications and improvement of metabolic control and state of health in diabetes cannot be effective only with medications. And now we need to develop different approaches – not only up to date pharmacological treatment of diabetes, but change the Self-Management Behavior among patients with Type 2 Diabetes.AimsTo assess the current status of diabetic self-management behavio...