Endocrine Abstracts

Introduction: Fracture incidence is increased during and after treatment for childhood acute lymphoblastic leukaemia (ALL). Studies using DXA, which measures a composite of both trabecular and cortical bone mineral density (BMD), have shown reduced BMD during treatment. We therefore used peripheral quantitative computed tomography (pQCT) to investigate changes in compartmental (cortical and trabecular) volumetric BMD (vBMD) and bone geometry, and evaluated the influence of tre...

Case: A 77-year-old man was admitted with a pathological fracture of the right femur, which required intramedullary nailing. He had previously been diagnosed with Paget’s disease affecting the right femur and also hyperparathyroidism with a large parathyroid adenoma on Sestamibi scan which had been managed at another hospital. On this admission, his corrected calcium was 2.79 (2.15–2.55) mmol/l, PTH 643 (15–65) pg/ml and alkaline phosphatase 258 (30–130) U/...

Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in type 2 diabetes mellitus. The aim of this study was to develop a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in type 2 diabetic patients. Seventeen type 2 diabetic patients, 10 obese non-diabetic and 17 non-obese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. In a mixe...

Objective: The presence of a single parathyroid adenoma is a cause of primary hyperparathyroidism in most cases. Minimally invasive parathyreoidectomy is a treatment of choice in PHPT patients and precise localization of the changed parathyroids is crucial for successful removal.The aim of the study was to assess usefulness of parathormone level estimation in the material obtained during FNAB of the focal neck lesions in order to differentiate structures...

Two progesterone receptor (PR) isoforms, the full-length PR-B and the N-terminally truncated PR-A, have distinct reproductive functions, with PR-B being required for a proper mammary gland development. The functional distinction between PR-B and PR-A has partially been attributed to the additional activation function (AF3) domain, localized within the PR-B-unique sequence (PR-BUS). Three highly conserved sequence motifs within AF3 domain are required for the strong transactiva...

Considering, the pivotal role of DC in formation and development of autoimmunological processes, the investigation of influence of of thyrometabolic status on maturation and function of subtypes of human peripheral blood DC, seems to be reasonable and of particular interest. THE AIM of the present study was a complex analysis of the dendritic cell subsets and fenotypes in patients with chronic thyroiditis (ChT) as well as the patients monitored for differentiated thyroid cance...

1-methyl-1-nitrosourea (MNU) is a well characterized carcinogen that induces adenocarcinomas in rat mammary gland with high specifity. This model has proven to be of resemblance to human breast cancer. Synthetic analogs of vitamin D3 and retinoids have shown some promise as chemopreventive agents against chemically induced mammary gland carcinogenesis in rodents.Female Sprague-Dawley rats were given 50 mg/kg MNU i.p. on 46th and 52nd day of ag...

AbstractThe aim of our research was to find different from estradiol steroid hormones that changes in their concentrations may be risk factors of coronary artery disease (CAD) in women.Material and methods:YM-CAD-38 menstruating women in the age of 42.6±3.4 years with past myocardial infarction and angiographically proven arteriosclerosis. YM-H- 15 healthy menstruating women in the age of 41.1&#17...

Background: TSH-suppressive therapy is widely used in treatment of thyroid differentiated carcinoma. A common consequence of therapy is subclinical hyperthyroidism which may cause dysfunction of cardiovascular system, metabolism and reduction of bone mass1. Thyroid hormones are also involved in regulation of brain function2. Therefore, it is not surprising that thyroid dysfunctions are associated with frequent comorbid cognitive dysfunctions and depressio...

Aim: To define concentrations (conc) of steroid hormones in patients (pts) with preserved gonadal function, suffering from coronary artery disease (CAD), and to assess their relations to patients’ weight.Material: Pts with coronarographically proved CAD: C-W group (gr)-52 women (W) in the age 43±3 years, with stable menstrual rhythm, C-M gr-46 men (M) in the age 52±6 years. Healthy volunteers: H-W gr-15 W (H-W) in the age 41±4 years, ...