Endocrine Abstracts

CNP belongs to a family of peptides best known for their role in blood pressure regulation and cardiac remodeling. However CNP differs from the cardiac hormones (ANP and BNP) in showing more diverse expression and low circulating plasma concentrations. Genetic studies, as well as showing cardioprotective roles for all three hormones, have revealed a critical role for CNP in promoting linear growth in both rodents and humans. Finding that the aminoterminal bio-inactive fragment...

Background: It is well established that diabetes-related complications are greatest in patients with a high HbA1c and in those who do not attend primary or secondary care clinics. For an equivalent reduction in HbA1c greater benefits are achieved in those with a high baseline.Aim: To determine if a simple action plan implemented by the Diabetes and Practice Nurse in primary care could improve glycaemic control.Methods: A primary ca...

Currently in the UK children and young people with diabetes receive variable provision of care and support in educational settings. There are concerns that this impacts on the young person’s glycaemic control, their quality of life, and their educational performance and outcome. Whilst most paediatric diabetes teams provide training for school staff, it may take several days, even weeks, after diagnosis before a diabetes educator is able to attend the school to provide ed...

IntroductionWe present the case of a 50-year-old lady who was referred to the endocrine clinic with a clinical and biochemical picture suggestive of severe thyrotoxicosis. CT scan of thorax, abdomen and pelvis (CT TAP) was performed to rule out malignancy, which showed left lobe agenesis.Case50-year-old lady presented to the GP with hyperhidrosis and unintentional weight loss. She also reported symptoms of le...

BackgroundPrimary aldosteronism (PA) affects 5-20% of all patients with hypertension, and is likely the most common treatable cause of hypertension. Patients with PA have higher risk of cardiovascular disease, atrial fibrillation and stroke. We aimed to estimate the prevalence of PA in patients with recent stroke.MethodsWe prospectively recruited 300 patients who were admitted to the acute stroke unit of a si...

Clin Endocrinology (Oxf), 2022, 96, 878-887 (DOI: https://doi.org/10.1111/cen.14681): ...

Introduction: Transcriptome analysis of peripheral blood mononuclear cells (PBMC) RNA has identified a set of androgen-responsive non-coding RNAs.Aim: To quantify the androgen-responsive gene expression and investigate its relationship to the testosterone (T) rise following hCG stimulation in boys with no genetic evidence of androgen insensitivity.Methods: Boys with suspected DSD who were evaluated at the Royal Hospital for Childre...

Introduction: Transcriptome analysis of peripheral blood mononuclear cells (PBMC) RNA has identified a set of androgen-responsive non-coding RNAs.Aim: To quantify the androgen-responsive gene expression and investigate its relationship to the testosterone (T) rise following hCG stimulation in boys with no genetic evidence of androgen insensitivity. Methods: Boys with suspected DSD who were evaluated at the Royal Hospital for Childr...

Introduction: Minimally invasive surgical treatment of primary hyperparathyroidism (PHPT) requires optimal preoperative localisation imaging. Parathyroid four-dimensional CT (4D-CT) has been reported to provide greater sensitivity than MIBI-SPECT/CT in localizing parathyroid adenomas. We analysed the additional value of 4D-CT in our cohort of PHPT patients.Materials and methods: Patients who attended our parathyroid clinic between February 2016 and April...

Introduction: Following treatment of Graves’ disease (GD), levels of thyrotropin receptor autoantibodies (TRAb) tend to decrease depending on treatment modality and length of follow up. We have assessed TRAb biological activity at follow up, years after GD treatment.Subjects and methods: TRAb concentration and biological activity were measured in 69 GD patients (59 females; 10 males; median age 59 years; TRAb positive at diagnosis), with follow up r...