Endocrine Abstracts

We report three patients who were referred for possible chronic fatigue syndrome and presented with a long standing history of a multitude of symptoms. Comprehensive investigations revealed a low IGF1 and subsequent insulin tolerance test (ITT) demonstrated growth-hormone (GH) deficiency with a normal MRI pituitary in each case. The first patient presented at the age of 34 years with lethargy, aches and difficulty concentrating. Biochemically the only abnormality in th]e basal...

Ghrelin as well as leptin are involved into regulation of food intake, development of obesity, diabetes (DM I, DM II) and inflammation. However, in spite of many experiments, the correlation between their effects are not fully established. As a part of study dealing with the interaction of ghrelin and leptin in metabolic disorders the present study was carried out to assess the effect of statin, DMI, DMII on the ghrelin and leptin plasma levels in lean and obese piglets. Anima...

Introduction: Currently, there are two glucagon-like peptide 1 (GLP-1) receptor agonists approved for the treatment of type 2 diabetes.While the primary pharmacological actions of GLP-1 agonists are antihyperglycaemic effect and weight reduction, these drugs may influence other neural and hormonal processes. Animal studies have indicated that GLP-1 receptors are involved in the regulation of stress, anxiety, learning and memory as well as regulation of c...

Background of Study: Some medications for the treatment of type 2 diabetes mellitus fail to achieve a continuous favorable glucose control in the long run during clinical use. Therefore we examined the durability of dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin which is relatively new to Japanese type 2 diabetic patients in clinical settings.Objectives and Methods: 117 subjects (M/F=65/52, Age: 66±10 y.o., duration of diabetes 12±8 y. b...

Aims: We present final Hellenic data from the INSTIGATE study on direct costs of care and resource use, over the 24 months after insulin initiation, in type 2 diabetic (T2D) patients.Methods: INSTIGATE, a prospective European observational study involving T2D patients who initiated insulin during usual care, assessed direct costs of care over the 6 months prior to and for the intervals from baseline to 6 months, 6–12, 12–18 and 18–24 month...

Introduction: There are concerns about the combined estrogenic effects of endocrine disrupting chemicals (EDCs), since mixtures of these chemicals exist in our environment. This study investigated potential synergistic interactions between bisphenol A (BPA) and isobutylparaben (IBP), which are major xenoestrogens used in the manufacture of plastics, cosmetics, drugs, and other products. The combined effects of these two chemicals were analyzed by measuring expression of calbin...

Breast cancer remains the leading cause of cancer-related death in Australian women. Up to 70% of post-menopausal tumours are estrogen-receptor positive (ER+), dependent on estrogen for continued growth and proliferative advantage. Adjuvant anti-estrogen therapies are considered the cornerstone approach to the treatment of such tumours, and research is ongoing to maximize its effectiveness. The major source of estrogens for ER+ breast cancers is local conversion of androgen pr...

The reproductive system is controlled by (GnRH) secretion from the brain, which is finely modulated by a number of factors, including gonadal sex steroids and inhibins. It was recently claimed that kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion. Therefore, we have developed highly specific and sensitive fluoro-immunoassays (FIAs) using Eu-labeled antigens for KP 10 and GnIH. In this study, the distributions of KP 10 and GnIH...

Introduction: Hyponatremia is common in hospitalised patients and can be due to a number of aetiologies. Investigations and management are often quite varied.Aims: To find out the prevalence, aetiology, investigations and management of hyponatremia in our hospitalised patients over a 2 week period (1 May and 15 May 2011).Methods: Case notes and electronic data assessment of all patients admitted with sodium level <130 mmol/l.</...

Background: The age of the onset of puberty is much lower today than in the past century, due to the stability of the socio-economic conditions, improved quality of life and overall health of the population.Materials and methods: We examined healthy 818 boys aged from 7 to 18 years, the study was conducted between 2009 and 2011.Boys were examined in three urban districts of Tashkent city (i.e. Mirzo-Ulugbek, Shakhantaur, Yunus-Abad...