Endocrine Abstracts

Aim: To estimate further results of treatment and outcomes in patients with subacute thyroiditis observed in the period from 1993 to 2005 years.Materials and methods: 102 patients (84 women, 18 men) with confirmed De Quervain’s subacute thyroiditis (SAT) were investigated and the findings were analysed retrospectively (clinical features, ultrasonography, laboratory tests).Results: There were 102 patients in the cohort within t...

UPD is a congenital disease characterized by the presence of two homologous chromosomes inherited from one parent in a diploid offspring. Its effects can be dramatic when the expression of essential genes is lacking. This is due to a phenomenon known as genomic imprinting where only one of the two chromosomal copies is active, depending on the parent of origin. Maternal uniparental disomy of the chromosome 14 (UPD 14 mat) is a rare disorder characterized by prenatal a...

Nutritional status has an important effect on the progression of any disease, not only in hospitalized patients, even more in ambulatory patient of primary care. Although there are many systems of evaluating nutritional status, they are costly and subject to variability amongst individuals. The Medicine Laboratory can correctly perform a nutritional evaluation in a quick an efficient manner.Objective: Analyze the nutritional status by CONUT nutritional e...

Background: The identification of patients with high risk of diabetes mellitus (DM) after renal transplantation in the pre-transplantation period is crucial for the prevention of this pathology and reduction of the risk of cardiovascular morbidity and mortality. With this study we intended to identify the risk factors for NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/20...

Background: The identification of patients with NODAT in renal transplantation is essential to establish adequate treatment and to reduce cardiovascular risk and graft failure. With this study we intended to evaluate the frequency of NODAT and to characterize patients with NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/2009 and 12/31/2013 were retrospectively evaluated. ...

Chronic kidney disease (CKD) is an important complication of diabetes and determinant of mortality. Albuminuria represents early diabetic nephropathy, and also indicates generalised vascular dysfunction. Understanding the epidemiology of CKD and albuminuria helps inform health planning and identify opportunities to prevent or delay progression of diabetic kidney disease. The last available serum creatinine and urine albumin/creatinine ratio (UACR) in patients with Type 1 (T1DM...

Introduction: D-aspartic acid (D-AA) is involved in the regulation of spermatogenesis by influencing hormonal biosynthesis and secretion, resulting in an increased sperm concentration and progressive motility. Coenzyme Q10 (CoQ10) correlates positively with sperm concentration and motility at high concentrations, and it plays an antioxidant role, improving sperm motility and fertilization rate in ICSI cycles. Finally, low concentrations of zinc (Zn) have been found in azoosper...

The sex hormone 17β-estradiol (E2) exerts its pleiotropic effects through the binding to the ligand-activated transcription factor estrogen receptor alpha (ERa). The E2:ERa complex regulates several physiological processes including cell survival and proliferation through transcriptional (i.e., estrogen responsive element (ERE)-based gene transcription) and non-transcriptional membrane-initiated effects (i.e., activation of signalling cascades).Many...

Introduction: LH and hCG act on the same receptor (LHCGR), have different half-lives and in vivo biopotency. It is not known whether they elicit the same cellular and molecular response. The aim of this study was to compare the kinetics of cAMP response to recombinant LH and hCG.Design: In COS-7 cells permanently expressing the human LHCGR (COS-7/LHCGR) we evaluated LH and hCG dose-response curves, by measuring total cAMP after 3 h of incubation. ...

Background: The growth hormone receptor (GHR) 6Ψ pseudoexon mutation (A to G at ds-1) is one of the most frequent mutations causing GH insensitivity. It causes aberrant mRNA splicing, leading to activation of a pseudoexon and insertion of 36 additional amino acids, resulting in a functionless receptor. Although IGF-I remains the mainstay of treatment for these patients we investigated the ability of RNA antisense oligonucleotides (ASOs) to correct aberrant GHR splicing us...