Endocrine Abstracts

Persistent organic pollutants (POPs) are environmental contaminants that interfere with normal hormonal homeostasis and act as endocrine disrupting compounds (EDC). These molecules can mimic hormone effects on metabolism. The links between metabolism and cancer are now well established. Metabolism generates reactive oxygen species (ROS), which contribute to mutations and induces oncogenic transformation. In turn, cancer cells display high metabolic flexibility allowing them to...

Background: The 3-year part of this trial investigated the effect of liraglutide 3.0 mg, as an adjunct to diet+exercise, in delaying onset of T2D (primary endpoint) in adults with prediabetes and obesity (BMI ≥30 kg/m2) or overweight (≥27 kg/m2) with comorbidities.Methods: Participants were randomised 2:1 to once-daily subcutaneous liraglutide 3.0 mg or placebo plus 500 kcal/day deficit diet and 150...

Introduction: Primary aldosteronism (PA) causes 15–25% of cases of drug-resistant hypertension (RBP). Adrenal vein sampling (AVS) is considered the gold standard for diagnosis of aldosterone aberrant secretion origin. The distinction between unilateral and bilateral disease dictates the targeted therapeutic approach, with surgery for aldosterone producing adenomas and medical therapy for patients with bilateral hyperplasia. As AVS is an invasive, not well standardized pr...

Introduction: PWS is the most common cause of genetic obesity. These patients have an abnormal body composition with increased amounts of fat mass (FM), reduced lean body mass (LBM) and diminished bone mineral density (BMD), all similar to patients with growth hormone deficiency (GHD).The abnormal body composition has been described due to impairment of the activity of GH-IGF system and to hypogonadism. Studies ongrowth hormone (GH) treatment in PWS adults from other European ...

Context: Androgen insensitivity syndrome (AIS) is a rare X-linked recessive disordercaused by mutations in the androgen receptor (AR) gene resulting in variable target tissue resistance to androgen action. The underlying molecular defect causes a spectrum of androgen dysfunction ranging from gynecomastia and/or infertility in mild AIS (MAIS) to variable degrees of ambiguous or undermasculinized genitalia in partial AIS to complete testicular feminization in complete A...

Introduction: The use of iSGLT2 continues to be controversial in diabetic patients with peripheral arterial disease.Objectives: Assess the metabolic effect and the risk of amputations of iSGLT2 in diabetic patients cared for in the Multidisciplinary Diabetic Foot Unit (MDFU) compared to a control group.Material and Methods: A retrospective observational study where patients attended at the MDFU from December 2017 to January 2020 we...

Introduction: Pregnant women are at risk for selenium deficiency, which is known to maintain adequate function of immune system and thyroprotective enzymes. Same, iodine is an essential micronutrient for thyroid hormone synthesis and important endocrine regulator of early brain development. Our previous study revealed that 81% of pregnant women in Latvia have insufficient levels of iodine. The aim of the present study was to evaluate iodine and selenium supply during pregnancy...

Aggressive adreno-cortical carcinoma (ACC) is a rare, aggressive malignancy, with poorly understood molecular pathogenesis. As a result, therapeutic options are currently limited, surgery being currently the lone curative modality. Most cases of ACC are sporadic, although some familial cancer syndromes (Li–Fraumeni, Beckwith–Wiedemann, MEN1, Carney complex, congenital adrenal hyperplasia, etc.) are associated with an increased incidence of ACC. The genes involved in ...

MEN1, autosomal dominant, is characterized by combined tumours of the parathyroid glands, pancreatic islet cells, and the anterior pituitary, sometimes associated with other endocrine (adrenocortical, foregut carcinoid) and nonendocrine (lipoma, angiofibroma, collagenoma, ependymoma, meningioma) tumors. It is caused by inactivating mutations of the MEN1 tumour suppressor gene (chromosome 11q13), encoding menin. Menin, involved in activation of gene transcription, regu...

Background: Type 2 diabetic (T2D) patients have alterations in the gut microbiota composition, compared to healthy individuals. Such alterations may play a role in the pathogenesis of T2D and insulin resistance. Bifidobacteria and Lactobacillus are among the most predominant bacteria found in human gut. They can also easily be added in probiotic preparations, thus making them ideal agents for therapeutic interventions. In this study, we aimed to determine if there were alterat...