Endocrine Abstracts

Objective: This study aims to investigate clinical and demographic variables associated with HRQoL as measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core Questionnaire (EORTC QLQ C30) Tagalog and the Thyroid Cancer-Specific Quality of Life Questionnaire (TCS QLQ) Tagalog.Methodology: 234 adult Filipinos with histopathologic-confirmed diagnosis of DTCafter thyroidectomy with or without radioactive ...

B lymphocytes are the source of autoantibodies against the thyroid--stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of autoimmune B-cell expression profiles might enable a better understanding of GD pathogenesis. To reveal this, the expression levels of long noncoding RNAs (lncRNAs) and mRNAs (genes) in purified B cells from patients with newly diagnosed GD and healthy individuals were compared using microarrays, which elucidated 604 differe...

Background: Glycaemic control and duration of diabetes mellitus play an important role in delaying or preventing diabetic retinopathy. NICE guidelines state that for type 1 diabetes, those aged 12 years and over must be offered annual retinopathy screening. This audit aims to assess compliance with the guidelines and the prevalence of retinopathy.Methods: This was a retrospective audit of paediatric diabetic patients registered to Good Hope Hospital atte...

A 57-year lady with a history of hypertension for which she was taking bendroflumethiazide and ramipril presented with a 1 week history of worsening frontal headache and vomiting. Twenty-four hours prior to admission she became confused, had photophobia, slurred speech and was unsteady. On examination she had a Glasgow coma score of 12, was apyrexial, normotensive, tachycardic and confused. Fundoscopy was normal. There was no neck stiffness and no cranial nerve palsies. Initia...

Background: Polycystic ovary syndrome (PCOS) is common with a suggested prevalence of 6–7% in Caucasian women of reproductive age. The presence of cardiovascular risk factors of obesity, insulin resistance and dyslipidaemia may predispose women with PCOS to coronary heart disease, although this remains controversial. This study aimed to contrast and compare the changes in lipid profile and hs-CRP following treatment with metformin, orlistat and pioglitazone in women with ...

A 67 y old man was brought to the A & E department after being found unresponsive. He was drowsy, hypotensive (BP 90/ 60 mmHg) and had low blood glucose of 1.2 mmol/L. Serum Na was 126 mmol/l (135–145) and K 3.5 mmol/L (3.5–5.0). CXR showed a left basal consolidation. Intravenous 10% dextrose and antibiotics were given. Twenty two years prior, he was diagnosed with squamous cell carcinoma of nasal septum associated with nodal involvement in the neck. He underwent...

Aim: To determine whether the ratio of T3 to TRAB (TSH Receptor Antibody levels) could be used to identify those patients with Graves’ thyrotoxicosis who cannot be controlled with antithyroid drug (ATD) therapy and those who will relapse within 2 years of discontinuation of ATD therapy.Method: Retrospective analysis of 22 patients with Graves’ disease and their relapse at 2 years after discontinuation of ATD therapy. Patients were diagnosed wit...

Research in recent years has shown that biochemically euthyroid levels of thyrotropin (TSH) and serum free thyroxine (FT4) as determined by laboratories may not necessarily equate to clinical well-being of patients. The defined normal range of TSH and FT4 are wide and may differ from patients’ optimal range of TSH and FT4. We have previously described a deterministic mathematical model that can predict each patient’s unique homeostatic set point, which gives the opti...

BackgroundAcute intermittent porphyria (AIP), a rare autosomal-dominant inherited disorder, caused by pathogenic mutations in the gene encoding porphobilinogen deaminase (PBGD). To explore its clinical characteristics, we investigated three patients with AIP admitted to our hospital.MethodsIn this study, patients successfully diagnosed with AIP and treated at the First Hospital of Shanxi Medical University si...

BackgroundThe reported HMBS mutations of acute intermittent porphyria(AIP) have been increasing gradually in China. We aim to explore its mutation characteristic in China and improve the understanding of its molecular heterogeneity.Material/methodsWe searched the literature about Chinese AIP patients with HMBS mutation in the PubMed, CNKI, Wanfang and CQVIP database, and 3 AIP patients with HMBS mutation in o...