Searchable abstracts of presentations at key conferences in endocrinology

ea0011p225 | Cytokines and growth factors | ECE2006

Vegf and sVCAM in patients with adrenal gland tumors

Britvin TA , Kushlinsky NE , Kazantseva IA , Sivtsova MA , Kalinin AP

The study presents the outcome of determination of serum VEGF and sVCAM in 58 patients (43 women and 15 men aged 20–76 years) with adrenal tumors: adrenal cortical adenoma (34), adrenal cortical carcinoma (12), pheochromocytoma (9), myelolipoma (2) and lymphangioma (1). Control group comprised 25 practically healthy volunteers (13 women and 12 men aged 17–67 years). Serum VEGF was measured by enzyme immunoassay using reactants from ‘R&D’ (USA), sVCAM &#...

ea0011p415 | Diabetes, metabolism and cardiovascular | ECE2006

Cardiac autonomic neuropathy in relation to some components of metabolic syndrome in newly diagnosed type 2 diabetic patients

Nishnianidze MA , Kurashvili RB , Khelashvili MG , Tsutskiridze LR , Bekaia MG

Background and Aims: Components of metabolic syndrome (MS) carry an increased risk for cardiovascular disease (CVD). People with abnormal glucose regulation are more prone to develop complications. At diagnosis 20-30% of type 2 diabetic (T2DM) patients (pts) already have neuropathy-one of the most dangerous complications. Cardiac autonomic neuropathy (CAN) is associated with five-fold risk of mortality. Our aim was to study possible relation between CAN and some components of ...

ea0007p9 | Bone | BES2004

Outcome of parathyroidectomy for primary hyperparathyroidism in 249 consecutive patients

Ma Y , Toogood A , Campbell D , Ready A , Gittoes N

Much has been written on the attributes of preoperative localisation and minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism. A recent 'summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century' (Bilezikian et al, 2002) suggested however that in experienced hands, conventional open parathyroidectomy with visualisation of all four glands was still the gold standard. In light of this we have carried o...

ea0073aep191 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Erythrocytosis in a patient on sodium glucose cotransporter-2 inhibitor

Byrne Shane , Nor Mohammad Aiman , Crotty Gerard , Kyithar Ma Pyeh

BackgroundSodium glucose cotransporter-2 (SGLT-2) inhibitors have proven valuable in the management of type 2 diabetes. These agents are particularly effective in reducing hospitalisations with heart failure and cardiovascular mortality. Adverse effects are primarily centred on urogenital infections and hypovolaemia. Here, we report the case of a patient who developed asymptomatic erythrocytosis while taking empagliflozin.Case repo...

ea0073aep446 | General Endocrinology | ECE2021

An audit of Multiple Endocrine Neoplasia type-1 (MEN-1) surveillance

Sim Sing Yang , Ma’en Al-Mrayat

IntroductionMultiple Endocrine Neoplasia type-1 (MEN-1) is an inherited autosomal dominant condition with a high degree of penetrance characterized by tumour occurrence in the form of pancreatic neuroendocrine (pNET), parathyroid and anterior pituitary gland tumours, among others. Treatment for MEN-1 associated endocrine tumour, particularly pancreatic, is more challenging than in those without MEN-1, given its multicentric nature and aggressive behaviou...

ea0073aep853 | Late Breaking | ECE2021

Giant invasive prolactinoma –a dramatic quick response to medical therapy

Yang Sim Sing , Ma’en Al-Mrayat

Giant prolactinomas are rare tumours, accounting for only 2–3% of all prolactin (PRL)-secreting tumours which can pose therapeutic challenges. It has a higher preponderance in men with a male to female ratio of about 9:1. A 70year old gentleman initially presented to the ophthalmology department with blurred and reduced colour vision. He denied any headache, galactorrhoea or gynaecomastia however he noticed reduced libido and difficulties with erections. His past medical ...

ea0037ep64 | Adrenal cortex | ECE2015

Serum brain-derived neurotrophic factor in Cushing's syndrome patients

Santos Alicia , Resmini Eugenia , Barahona Ma Jose , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Marin Ana , Webb Susan M

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

ea0014p45 | (1) | ECE2007

Progression of diabetic retinopathy in pregestational diabetes mellitus

Guerrero R , Martinez Brocca MA , Pomares MA , Palma S , Gonzalez I , Acosta D , Moreno E , Villamil F

Background: Pregnancy may adversely affect the progression of diabetic retinopathy and can have serious implications for the pregnant women.Aim: To asses the impact of pregnancy on the progression of diabetic retinopathy in women with type 1 and type 2 diabetes mellitus and to identify risk factors for the progression of retinopathy during pregnancy.Methods: 306 diabetic women, 229 (75.4%) with type 1 and 77 (23.9%) with type 2 di...

ea0049ep99 | Adrenal medulla | ECE2017

Role of urinary fractionated metanephrines and catecholaminas in the diagnosis of pheochromocytoma/paraganglioma

Martinez-Triguero Ma Luisa , del Olmo Ma Isabel , del Olmo Rosa Camara , Alba Amparo , Fernandez Francis , Merino Juan Francisco , Laiz Begona

Introduction: Paragangliomas/pheochromocytomas present frequently with vague symptomatology which makes its diagnosis difficult and challenging. Cuantification of fractionated metanephrines and fractionated catecholamines in 24 h urine sample are used for diagnosis. There are situationes that can produce false positive results such as stress, drugs or smoking that must be taken into account.Patients and methods: Retrospective study on the requests made f...

ea0041gp127 | Neuroendocrinology | ECE2016

Hypothalamic GRK2, via GPR54, modulates puberty onset

Avendano Ma Soledad , Ruiz-Pino Francisco , Vazquez Ma Jesus , Velasco Inmaculada , Heras Violeta , Torres Encarni , Manuel Castellano Juan , Roa Juan , Pinilla Leonor , Tena-Sempere Manuel

The G protein-coupled receptor (GPCR) kinase 2, GRK2, is a ubiquitous serine/threonine protein kinase that is able to phosphorylate and desensitize the active form of several GPCR. Compelling, as yet limited, evidence from in vitro studies have suggested a potential role of GRK2 in mediating desensitization of Gpr54, the canonical receptor for kisspeptins that is abundantly expressed in GnRH neurons. Yet, although kisspeptins have been universally recognized as essent...