Endocrine Abstracts

Introduction: Insulinomas are pancreatic neuroendocrine tumors (PNET), characterized by insulin hypersecretion syndrome with the development of hypoglycemia. The incidence of the tumor is 3-10 cases per million inhabitants. The average age of onset is 40-50 years old, being more frequent in women. Case Reports: We present a clinical case of a patient with CREST syndrome and difficult-to-control hypoglycemia. Female patient, 81 years old, with a history o...

Background and aims: The mechanisms underlying placenta oxidative stress co-existing with alterations in maternal-placenta interactions during gestational diabetes mellitus (GDM) are not well understood. We sought to evaluate the levels of oxidative stress markers and antioxidants in women with GDM, and to assess the impact on placenta.Material and methods: Pregnant women (63 with GDM, 63 controls) were enrolled, together with 41 cases and 21 controls fo...

Introduction: New treatments of diabetes, such as dapagliflozin, improve global metabolic status beyond glycemic control.Aim: To evaluate tolerance to dapagliflozin and its effects on metabolic control in type 2 diabetes and obese patients attended in endocrinology offices.Material and method: A prospective study of patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and analytical data were evaluated ...

Bariatric surgery (BS) improves quality of life and health due to the beneficial effect on the metabolism at multiple levels. Specifically, its effectiveness in weight loss and the attenuation or resolution of comorbidities associated with obesity, means lower morbidity and mortality compared to other types of interventions. The objective is to analyze the evolution of obesity-related diseases after twelve months of follow-up.Methods: Retrospective study...

Zoledronic acid (ZA) treatment increases bone mineral density (BMD), decreases bone turnover markers and reduces the risk of fractures in patients with osteoporosis (1).Objective: Observe and quantify the changes in BMD and bone turnover markers in postmenopausal osteoporosis (PO) patients treated annually with zoledronic acid 5 mg intravenously.Material and Methods: Medical records (MR) of PO patients whom received ZA from 2007 to...

Introduction: Dyslipidemia (DL) in diabetic patients is frequently undertreated. Even when cLDL targets have not been met, treatment remains unchanged despite the availability of alternatives approaches. This is known as therapeutic inertia (TI).The aim of this study was to evaluate the prevalence of TI in lipid management among diabetic patients and to analyse associated factors and possible causes.Material and Methods: Retrospective, cross-sectional st...

Objective: An adequate thyroid function during pregnancy is essential for the normal brain development of the foetus, and some organochlorine compounds (OCs) can interfere with the thyroid system. The objective of the present study was to evaluate the association between exposure to some OCs and thyroid function in pregnant women from two different areas in Spain, as well as to investigate the potential confounding effect of iodine intake.Methods: Thyroi...

Introduction: The fetus is the most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy. Severe iodine deficiency and hypothyroidism during pregnancy have long been known to be associated with neurologic deficits and mental retardation The effects of mild iodine deficiency and subclinical hypothyroidism are poorly known. The present study assesses the association between thyroid hormones and urinary iodine concentration (UIC) in healthy pregnant women an...

Objective: To evaluate continuous subcutaneous insulin infusion (CSII) in type 1 diabetes using the analysis of epidemiological variables, treatment indications, metabolic results, acute and chronic complications and causes for therapy suspension.Methods: A retrospective descriptive study of patients with type 1 diabetes treated with CSII therapy in our institution.Results: A total of 49 type 1 diabetic patients who had been treate...

Background: Neuroendocrine cancers arise in the endocrine cells localized throughout the body. Most are found in the Gastroenteropancreatic (GEP) system pancreas, stomach, and small and large intestines. They are heterogenous in their etiology, morphology, and phenotypes. Due to late diagnosis and low prevalence, clinical specimens are limited for research. Thus, preclinical models are pivotal for the understanding of this disease. This study focuses on establishing a novel pa...