Endocrine Abstracts

Introduction: Patients with bariatric surgery require close monitoring because of possible metabolic complications. It has been published some cases of severe and persistent hypoglycemias resistant to diet and pharmacologic treatment being necessary a pancreatectomy. We present a case report of nesidioblastosis after gastric bypass that required subtotal pancreatectomy but despite this, hypoglycemias persisted. Before performing total pancreatectomy we placed a tube feeding in...

RAP KO mice have a reduction of colloidal Tg resulting in subclinical hypothyroidism and histological signs of goiter. The difference in colloidal Tg between RAP KO and WT mice was striking by immunohistochemistry, but could not be detected in thyroid extracts. To explain this discrepancy, we hypothesized that the reduction of Tg reflected a reduction of Tg aggregates discarded during tissue extraction. To investigate this possibility, pellets obtained by thyroid homogenizatio...

Megalin is a member of the LDL receptor family expressed by several epithelial cells where it mediates endocytosis of ligands. In the thyroid megalin is responsible for transcytosis of hormone-poor thyroglobulin (Tg) molecules. This process favors hormone release by preventing hormone-poor Tg to enter the lysosomal pathway, where hormones are cleaved from hormone-rich Tg molecules. Accordingly, megalin KO mice have a distinct thyroid phenotype with primary hypothyroidism. In r...

Whether TTA affects GO remains to be established. Here we studied the effects of TTA in 90 patients with mild-moderate GO randomized into 3 groups of thyroid treatment: MMI (methimazole), TX [near-total thyroidectomy (NTTX)], TTA (NTTX plus 131-I). Patients were treated with ivGC and evaluated at 3 and 9 mo. GO was considered improved or worsened when at least 2 of the following criteria changed, either positively or negatively: i) proptosis and/or eyelid width by at least 2 m...

Introduction: Vitamin D deficiency is very common in our population.It is not clear which is the most effective vitamin D dosing regimen in patients with deficiency.Objective: To compare two vitamin D supplementation regimen in patients with vitamin D deficiency.Material and methods: This is an interventional study: Patients atended in our clinic during May and June 2017 with 25-Hydroxyvitamin D below 30 ng/ml were consecutively se...

Introduction: Iodine is essential for thyroid funciton and severe deficiency adversely affects the developing brain. A raised and sufficient intake is particularly important during the pregnancy. Iodine sources include sea foods and sea salt, and it is available as a dietary supplement. The former was previously important to the Faroses diet but the intake of traditional Faroses foods is decreasing with at likely parallel influence on the iodine intake. Currently, there is no ...

Introduction: Changes in dietary habits coupled with sedentary lifestyles have led to a true pandemic of obesity. This situation has also been observed in the new nutrition consultation at La Merced Hospital in Osuna (Seville), where, after 6 months of operation, 88.9% of the patients were referred due to obesity.Objective: To analyze the profile of patients referred for obesity to the nutrition consultation at La Merced Hospital, as well as the sources ...

Background and aims: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Osteoporosis are two silent prevalent metabolic conditions. MASLD involves fat accumulation in the liver, along with at least one of five specified cardiometabolic criteria, while excluding other liver diseases or secondary causes. Osteoporosis is a systemic skeletal condition characterised by reduced bone mass, leading to increased fracture risk. The relationship between MASLD and decrea...

Introduction: The autoimmune polyglandular syndrome is a complex, heterogeneous disease in which autoimmune diseases of endocrine and non-endocrine organs can occur. There are 4 subgroups: the early-onset APS I develops due to the mutation of the gene AIRE and characterized by the presence of Addison’s disease (AD), mucocutan candidiasis and hypoparathyroidism; the APS II is defined by the appearance of AD and autoimmune thyroid diseases (AITDs) and/or diabetes mellitus; ...

Introduction: Both cortisol and vasopressin are stress hormones. Earlier, our group demonstrated that serum concentrations of free cortisol at admissions to the Intensive Care Unit (ICU) were independent predictors of survival in critically ill patients. Other investigators have demonstrated that serum copeptin, a surrogate marker of vasopressin may also be a predictive factor in this patient population. The aim of our present study was to compare the prognostic roles of serum...