Searchable abstracts of presentations at key conferences in endocrinology

ea0086p352 | Neuroendocrinology and Pituitary | SFEBES2022

The heart bleeds – complex management of a patient with acromegaly, cardiomyopathy and mechanical mitral valve

Sharma Aditi , Nyunt Sandhi , Narula Kavita , Mitchell Catherine , Mendoza Nigel , Yong Yong , Hatfield Emma , Meeran Karim , Martin Niamh

A 44 year old gentleman presented to his local hospital with a two week history of fevers and rigors. Blood cultures were positive for Streptococcus oralis, and an echocardiogram confirmed new diagnosis of hypertrophic cardiomyopathy (HCM) complicated by mitral valve infective endocarditis (IE). Unfortunately, this required a mechanical mitral valve replacement (MVR) and he started warfarin (INR target 2.5-3.5). During his admission, he reported chronic headaches. An MRI brain...

ea0090ep759 | Pituitary and Neuroendocrinology | ECE2023

Endocrinopathy behind the facemask – follow up

Nyunt Sandhi , Sharma Aditi , Narula Kavita , Mitchell Catherine , Mendoza Nigel , Ling Yong Yong , Hatfield Emma , Meeran Karim , Martin Niamh

A 44-year-old gentleman presented to the Emergency Department with a 2-week history of fever and rigors. Past medical history was unremarkable other than an earlier diagnosis of hypertension. He was noted to have new onset atrial fibrillation with rapid ventricular response; a diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) was made on echocardiography. In addition, a vegetation was identified on the mitral valve. Treatment for infective endocarditis (Streptoco...

ea0091p37 | Poster Presentations | SFEEU2023

Craniopharyngioma: A Comprehensive Overview of a Challenging Pituitary Mass

Mcgown Patrick , Narula Kavita , Nair Ramesh , Gontsarova Anastasia , Jaunmuktane Zane , Ferguson Mark , Mendoza Nigel , Martin Niamh , Meeran Karim , Mehta Sanjeev

Case history : A 44-year-old female presented with 6-week history of gradual deterioration in her left vision associated with eye pain. She saw an ophthalmologist who noted that she had reduced visual acuity (6/24) and colour vision (Ishihara colour vision score 3/15) in her left eye with left relative afferent pupillary defect (RAPD). It was thought that she may have a left retrobulbar neuritis so she was advised to attend A&E for an urgent neurology assessment. On examin...

ea0065p321 | Neuroendocrinology | SFEBES2019

A suprasellar germ cell tumour presenting with cranial diabetes insipidus

Samarasinghe Suhaniya , Scott Rebecca , Seckl Michael J , Gonzalez Mike , Harvey Richard , Unsworth Nick , Hatfield Emma , Martin Niamh , Meeran Karim

A 30-year-old female presented to her general practitioner with a three-month history of fatigue, visual disturbance, polydipsia and dizziness. She was treated for iron deficiency anaemia, but re-presented two-months later with new-onset headache and worsening visual disturbance. Previously, she had childhood leukaemia, treated in Brazil with no cranial irradiation. On examination there was left eye loss of light/dark perception and right temporal vision loss. She was referred...

ea0038p114 | Clinical practice/governance and case reports | SFEBES2015

Variation in levels of macroprolactin in the investigation of secondary hypogonadism

Ali Sabreen , Abbara Ali , Comninos Alexander , Ramli Rozana , Cegla Jaimini , Martin Niamh , Hatfield Emma , Sam Amir , Meeran Karim

Introduction: Macroprolactin is a physiologically inactive form of prolactin, usually composed of a prolactin monomer and an IgG or anti-prolactin antibody molecule. Whilst clinically non-reactive, it interferes with immunological assays used for prolactin detection. It is identified by polyethylene glycol (PEG) precipitation, and levels of macroprolactin are generally believed to remain stable over time.Case: We present the case of a 36-year-old gentlem...

ea0038p316 | Pituitary | SFEBES2015

Does basal post-operative early morning cortisol measurement predict HPA axis integrity as assessed by an insulin tolerance test in patients who have undergone pituitary surgery?

Ahmad Syed Mustafa Ali , Papadopoulou Debbie , Hatfield Emma , Mendoza Nigel , Nair Ramesh , Meeran Karim , Martin Niamh M

Background: Correct identification of patients with HPA axis dysfunction following trans-sphenoidal pituitary surgery is important. Our centre measures post-operative day 5 0900 h serum cortisol (24 h after the last dose of glucocorticoid) to identify the need for glucocorticoid replacement. This is given if post-operative day 5 0900 h cortisol concentration is <300 nmol/l, until dynamic pituitary function assessment occurs.Methods: Data were reviewe...

ea0018oc1 | (1) | MES2008

Bilateral adrenalectomy in a patient with congenital adrenal hyperplasia

Chaudhri Owais , Hatfield Emma , Wynne Katie , Palazzo Fausto , Mehta Sanjeev , Shaikh Humera , Tan Tricia , Martin Niamh , Meeran Karim

We present the case of a 33-year-old woman diagnosed with congenital adrenal hyperplasia (CAH) due to classical 21-hydroxylase deficiency following a salt-losing crisis as a newborn. She had previously been controlled on dexamethasone 0.25 mg bd and fludrocortisone 100 mcg od, as evidenced by high-normal 17-hydroxyprogesterone (17-OHP) and low-normal testosterone levels (8.5 and 0.4 nmol/l respectively).However, she had experienced significant symptoms o...

ea0018oc4 | (1) | MES2008

MEN1: the full house

McGowan Barbara , Fountain Annabel , Chaudhri Owais , Mehta Puja , Tan Tricia , Hatfield Emma , Martin Niamh , Todd Jeannie , Meeran Karim

This gentleman was diagnosed with hyperparathyroidism at the age of 34 and was found to have multiple manifestations of MEN1.Hyperparathyroidism: He was diagnosed with hyperparathyroidism and underwent a parathyroidectomy with removal of 2 glands. Four years later calcium levels were raised once again and two further hyperplastic glands were removed, with cure of his hypercalcaemia.Gastrinoma and other pancreatic islet cell tumours...

ea0065oc4.4 | Thyroid | SFEBES2019

Development of auto-immune thyroid dysfunction in multiple sclerosis patients receiving Alemtuzumab is associated with improved response to treatment

Sovetkina Alina , Nicholas Richard , Malik Omar , Tona Francesca , Dorsey Rachel , Scalfari Antonio , Rigoni Eleonora , Nandoskar Ashwini , Singh-Curry Victoria , Martin Niamh

Background: Alemtuzumab is an anti-CD52 monoclonal antibody used in the treatment of relapsing-remitting multiple sclerosis (MS). Between 20 and 40% of Alemtuzumab-treated MS patients develop autoimmune thyroid disease (AITD) as a side effect. It is currently unknown whether development of AITD correlates with MS disease activity following Alemtuzumab treatment.Aims: To characterise the types and frequency of AITD that MS patients develop following Alemt...

ea0041ep281 | Clinical case reports - Pituitary/Adrenal | ECE2016

Managing a complex case of acromegaly – lessons to learn

Lye Yap Hsiu , Hatfield Emma , Martin Niamh , Assomull Ravi , Berry Stewart , Mehta Amrish , Falconer Alison , Mendoza Nigel , Meeran Karim , Mehta Sanjeev

Our 42-year-old patient presented with breathlessness and signs of congestive cardiac failure. Her ‘spade-like hands and acromegalic appearance’ were noted on the post-take round. She had headaches, orthopnoea and secondary amenorrhoea. She was a poorly controlled diabetic (so OGTT was not performed), anaemic, and previously had a thyroidectomy.Pituitary profile showed secondary hypogonadism, normoprolactinaemia and normal free T4 indicating ad...