Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep771 | Pituitary: clinical | ECE2015

Association of hormonal changes with disease severity and mortality rate in critically ill patients

Cuhaci Neslihan , Ogmen Berna , Doger Cihan , Polat Burcak , Izdes Seval , Ersoy Reyhan , Cakir Bekir

Introduction: Endocrinological and metabolic changes can occur in critically ill patients, which may affect the prognosis and outcome. The hypothalamic–anterior–pituitary axis (HPA) plays a crucial role in the endocrine regulation of metabolic and immunological homeostasis. In this prospective study, we evaluated the pituitary–adrenal–gonadal–thyroid axis in the adult Intensive Care Unit (ICU) patients,their outcome, the association between these hormo...

ea0037ep1277 | Clinical Cases–Thyroid/Other | ECE2015

Clinical and hormonal characteristics of a series of patients affected by inappropriate TSH syndrome: insights into the differential diagnosis

Polat Sefika Burcak , Aydin Cevdet , Kaya Mina Gulfem , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Normal or elevated TSH level in the presence of elevated T4 is defined as ‘inappropriate TSH syndrome’. Two main clinical conditions that can lead that syndrome are TSH-secreting adenoma (TSHoma) and resistance to thyroid hormone (RTH). Making the correct diagnosis is crucial in order to decide the most appropriate treatment option. Herein we presented clinical and laboratory data of seven patients who were hospitalised for the differential d...

ea0035p147 | Calcium and Vitamin D metabolism | ECE2014

Hypoparathyroidism and celiac disease a rare autoimmune disease combination

Ogmen Berna , Cuhaci Neslihan , Polat Burcak , Aydin Cevdet , Ersoy Reyhan , Cakir Bekir

Case: A 30-year-old man with hypoparathyroidism has been treated with calcitriol and calcium for 2 years, admitted hospital with persisting diarrhea. An endoscopic operation is planned. But when he was waiting for this examination as outpatient condition, he had a convulsion and had been taken in hospital by parents. Initial laboratory analyses revealed that he was hypocalcemic (total calcium of 6 mg/dl) and parathormone (PTH) 8 pg/ml, phosphorus 5.7 mg/dl, and magnesium 2 mg/...

ea0035p153 | Calcium and Vitamin D metabolism | ECE2014

The change in paratyroid hormone level by posture in primary hyperparathyroidism

Aydin Cevdet , Polat Sefika Burcak , Dirikoc Ahmet , Evranos Berna , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Major factor that modulates the PTH secretion is serum Ca level. Paratyhyroid gland also receives direct autonomic innervation. To date, measurement of several hormones such as cortisol,prolactin, renin and aldosteron were found to be affected by changing the posture from recumbent to the upright position. In the present study, we aimed to investigate postural change of PTH in normal individuals and patients with primary hyperparathyroidism (PHPT).<p class="a...

ea0035p374 | Diabetes (epidemiology, pathophysiology) | ECE2014

New onset T1DM after vaccination for measles: Coincidence or consequence?

polat Burcak , Aydin Cevdet , Evranos Berna , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Viruses and virus-induced lymphokines may have an important role in the pathogenesis of autoimmunity. The occurrence and significance of autoimmune manifestations after the administration of viral vaccines remain controversial. Herein we have represented a case who developed type 1 diabetes 1 month after vaccination for measles in military.Case: A 25-year-old male patient admitted to our clinics with the complaints of polyuria, poydipsia, a...

ea0035p436 | Diabetes complications | ECE2014

Markers of endothelial dysfunction in type 1 diabetics with or without microalbuminuria

Polat Sefika Burcak , Ugurlu Nagihan , Sari Cenk , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Diabetic nephropathy (DN) is an important one of the complications and is detected in almost 30-40% of the patients with type 1 diabetes mellitus (T1DM). Besides the well known risk factors, endothelial dysfunction also plays a role in the pathogenesis of DN and diabetic retinopathy. Our aim was to determine flow mediated dilation measurements and serum soluable ET-1, ICAM-1, and VCAM-1 levels in T1DM patients with or without inceased albumin excretion and compar...

ea0035p447 | Diabetes complications | ECE2014

Prolonged cerebellar ataxia after: severe hypoglycemic attack in a patient with T1DM: a rare but disturbing sequela

Polat Burcak , Aydin Cevdet , Evranos Berna , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Hypoglycemia is common in people with diabetes who aim to achieve strict glucose control. The neurologic manifestations of hypoglycemia are mostly reversible and includes behavioral changes, difficulty in concentration, confusion, loss of fine motor functions, and seizures. Herein we have presented a case who was pregnant and experienced severe hypoglycemia which led to permanent ataxia.Case: A 26-years-old female patient was brought to our...

ea0035p635 | Female reproduction | ECE2014

Thyroid disorders in young females with polycystic ovary syndrome: is thyroid volume associated with serum IGF1 level?

Polat Sefika Burcak , Oguz Oguzhan , Sacikara Muhammed , Cuhaci Neslihan , Evranos Berna , Ersoy Reyhan , Cakir Bekir

Background: PCOS is one of the most common disorders affecting at least 5–10% of women of reproductive age. Increased prevalance of autoimmune thyroiditis and goiter were reported in PCOS patients. This study investigated the prevalance of hypothyroidism, thyroid autoimmunity, ultrasonographic features and presence of nodules in PCOS patients and compare them with the control group. We also aimed to detect correlation of thyroid volume (TV) with serum IGF1 levels in patie...

ea0035p894 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

‘High dose hook effect' in a patient with invasive giant prolactinoma

Ogmen Berna , Aydin Cevdet , Polat Burcak , Cuhaci Neslihan , Altundal Naci , Ersoy Reyhan , Cakir Bekir

Background: Prolactin secreting pituitary adenomas (prolactinomas) is the most common pituitary adenoma. The magnitude of prolactin secretion in prolactinomas is usually proportionate to the tumor’s size. Invasive giant prolactinoma is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/ml and mass related clinical symptoms. Giant prolactinoma is rare and usually presents in men.Case report: A 52-year...

ea0035p916 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Lanreotide-induced bradycardia and supraventricular extrasystoles

Ogmen Berna , Polat Burcak , Cuhaci Neslihan , Aydin Cevdet , Ersoy Reyhan , Cakir Bekir

Case: A 63-year-old acromegalic woman admitted hospital for lassitude and dizziness. She has been diagnosed acromegaly 10 years ago and had two transsphenoidal operations. Remission wasn’t achieved. Then she started to use lanreotide (somatostatin analogue) and for 7 years she has been treated with it. In laboratory examination, basal plasma GH 1.21 ng/ml (NR:0–5); nadir GH level after glucose tolerance test, 1.2 ng/ml (NR: less than 1); IGF1, 129.1 ng/ml (NR: for ag...