Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep195 | Endocrine tumours and neoplasia | ECE2017

Malignant pheochromocytoma – a challenging diagnosis with nonconsensual management

Castro Oliveira Sofia , Sergio Neves Joao , Souteiro Pedro , Lau Eva , Isabel Oliveira Ana , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytomas and extra-adrenal paragangliomas are rare neuroendocrine tumors, with a peak incidence between the 3rd–5th decades of life and about 10% are malignant. Although they have the same radiographic and histologic characteristics of their benign counterpart, malignant pheochromocytomas are diagnosed by the presence of local invasion or metastatic tumor in the non-chromaffin tissues, and offer a poorer prognosis. Treatment is typically extirpative...

ea0041gp197 | Thyroid - Basic | ECE2016

Evaluation of interrelations between resistin, adiponectin, PAI-1, intercellular adhesion molecule and thyroid function in autoimmune thyroid disease

Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Esteves Cesar , Sokhatsha Oksana , Delgado Luis , Medina Jose Luis , Carvalho Davide

Introduction: Given the significant impact of thyroid function on body weight, energy metabolism and adipocytes physiology, our aim was to study the impact of subclinical thyroid dysfunction in plasmatic levels of adipokines and ICAM-1 (intercellular adhesion molecule 1).Methods: We evaluated 98 patients with autoimmune thyroid disease divided into three groups: 30 who were euthyroid (TSH=0.35–4.94 UI/ml), 35 with subclinical hypothyroidism (hypoSC,...

ea0037ep1296 | Clinical Cases–Thyroid/Other | ECE2015

Radioguided excision of occult metastatic lesion in thyroid carcinoma: a safe technique for previously operated neck in two patients

Martins Teresa , Azevedo Teresa , Santos Jacinta , Rodrigues Fernando , Rovira Eugenia , Oliveira Sofia , Neto Joao , Neves Antonio , Gilde Patricia , Cruz Carlos

Introduction: Intraoperative identification of neck lesions in patients who have undergone previous neck surgery is particularly difficult, because of operative scarring and distorted anatomy. Radioguided occult lesion localisation (ROLL) involves the preoperative intratumoral ultrasound-guided injection of a radioactive tracer. In the present study, we investigated the efficacy of roll in two patients with papillary thyroid cancer (PTC) who underwent previous neck exploration...

ea0056oc4.4 | Novel insights into prediabetes and type 2 diabetes | ECE2018

Association between prediabetes and incidence of chronic kidney disease, incident albuminuria, or worsening of kidney function: a secondary analysis of the SPRINT trial

Neves Joao Sergio , Vieira Miguel Bigotte , Magrico Rita , Leitao Lia , Dias Catarina Viegas , Baptista Rute Baeta , Oliveira Ana , Carvalho Davide

Introduction: Diabetes is a major risk factor for chronic kidney disease (CKD). Previous studies have shown contradictory results regarding the effect of prediabetes in the development of CKD.Methods: We performed a secondary analysis of the SPRINT trial (Systolic Blood Pressure Intervention Trial) involving 9361 patients without diabetes and with an increased cardiovascular risk (clinical or subclinical cardiovascular disease, estimated glomerular filtr...

ea0073pep10.6 | Presented ePosters 10: Thyroid | ECE2021

Influence of pro-inflammatory cytokines polymorphisms on the interrelationship between Graves’ disease and diabetes

Celestino Neves , Neves Joao Sergio , Paula Soares , Delgado Luís , Luís Medina Luís , Carvalho Davide

BackgroundGraves’ Disease (GD) is characterized by production of stimulating autoantibodies to thyrotropin receptor resulting in hyperthyroidism. Hyperthyroidism is associated with insulin resistance, hyperglycemia and ketosis. Our aim was to evaluate if single nucleotide polymorphism (SNP) in pro-inflammatory cytokines contributes to dysglycemia in GD.MethodsWe evaluated 98 patients with Graves’ di...

ea0063gp76 | Thyroid Autoimmune Disorders | ECE2019

Cardiovascular risk factors, autoimmunity and insulin resistance in Graves disease

Ferreira Catia Tomas , Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Sokhatska Oksana , Pereira Miguel , Oliveira Ana , Medina Jose Luis , Delgado Luis , Carvalho Davide

Introduction: Graves’ disease is an autoimmune disease accounting for the majority of hyperthyroidism cases.Aim: We aimed to assess the interrelationships between cardiovascular risk factors, autoimmunity, insulin resistance and treatment in Graves’ disease.Material and methods: We measured free T3 (FT3), free T4 (FT4), TSH, thyrotropin receptor antibodies (TRAb), anti-thyroglobulin and anti-TPO antibodies, thyro...

ea0063gp77 | Thyroid Autoimmune Disorders | ECE2019

Lipid profile, insulin resistance and cytokines evaluation in autoimmune thyroiditis patients

Goncalves Juliana , Neves Celestino , Pego Francisco , Neves Joao Sergio , Oliveira Sofia Castro , Sokhatska Oksana , Pereira Miguel , Oliveira Ana , Medina Jose Luis , Delgado Luis , Carvalho Davide

Introduction: Thyroid dysfunction has been associated with cardiovascular events since it worsens atherogenesis, insulin resistance and dyslipidemia. Thyroid hormones and adipokines interact with each other to regulate metabolism. The impact of thyroid dysfunction on adipokines serum levels remains controversial.Objective: To evaluate the interrelations between thyroid function and cardiovascular risk factors as insulin resistance, lipid profile, inflamm...

ea0063gp78 | Thyroid Autoimmune Disorders | ECE2019

Autoimmune thyroiditis, Graves’ disease and adiponectin, resistin and plasminogen activator inhibitor-1 levels

Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Sokhatska Oksana , Pereira Miguel , Oliveira Ana , Medina Jose Luis , Delgado Luis , Carvalho Davide

Introduction: The interrelationship between autoimmune thyroiditis, Graves’ disease and plasma adipokines levels remains elusive.Aims: We aimed to compare the levels of adiponectin, resistin and PAI-1 levels in patients with autoimmune thyroiditis and Graves’ disease.Subjects and methods: We recorded thyroid function tests, BMI, the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein...

ea0063p1208 | Thyroid 3 | ECE2019

Thyroid uptake in PET-CT: IPO-porto consecutive case series

Ferreira Paulo Carvalho , Sampaio Ines Lucena , Violante Liliana Sobral , Teixeira Joao Pedro , Neves Joao Sergio , Gomes Vania Rodrigues , Mota Filipe , Duarte Hugo

Introduction: Positive radiotracer uptake by the thyroid gland can occur in PET-CT. It’s meaning has led to conflicting results mainly resulting from small studies.Objective: We aim to present a large single institution consecutive case series.Material and methods: Observational, descriptive and retrospective study of the PET-CT scans performed between the years 2000–2017. We searched the word thyroid in the computer imag...

ea0049gp199 | Thyroid 1 | ECE2017

Cardiovascular risk factors in patients with autoimmune thyroiditis

Neves Joao Sergio , Cunha Catarina , Neves Celestino , Oliveira Sofia Castro , Sokhatska Oksana , Dias Camila , Esteves Cesar , Pereira Miguel , Medina Jose Luis , Delgado Luis , Carvalho Davide

Background: Overt thyroid dysfunction is associated with an increased cardiovascular risk. The impact of subclinical hypothyroidism and autoimmunity in the increased cardiovascular risk remains controversial. Aim: To evaluate the interrelations between thyroid function, thyroid autoimmunity and cardiovascular risk factors, in patients with autoimmune thyroiditis (AIT).Methods: 353 subjects with AIT were evaluated. We defined three groups based on TSH lev...