Endocrine Abstracts

Primary squamous cell carcinoma of the thyroid gland (PSCCT) is a rare neoplasm of the thyroid with a poor prognosis. We present a 70-year-old male patient who presented with a progressively growing mass on the left side of the neck causing shortness of breath. The patient presented with suspicious poorly-differentiated malignancy as a result of the thyroid fine-needle aspiration cytology performed due to the rapidly growing mass. No other primary tumor focus was detected in t...

Congenital imprinting disorders (IDs) are a group of rare conditions affecting growth, metabolism and development caused by aberrant expression of imprinted genes in a parent-of-origin dependent manner. The internationally recognised IDs are Prader Willi Syndrome (PWS), Angelman Syndrome (AS), Beckwith Wiedemann Syndrome (BWS), Silver Russell Syndrome (SRS), Temple Syndrome (TS14), Pseudohypoparathyroidism (PHP), Transient Neonatal Diabetes Mellitus (TNDM) and Kagami-Ogata Syn...

Introduction: Prolonged therapy with high-dose corticosteroids (≥ 7.5 mg Prednisolone or 1–1.5 mg Dexamethasone daily) can result in adrenal atrophy and hypofunction. Abrupt withdrawal of corticosteroids after prolonged use can lead to adrenal insufficiency, corticosteroid withdrawal symptoms or a relapse of the initial disease. There are several in-house protocols for safe corticosteroid dose tapering but a national protocol is required.Our p...

Introduction: Iododerma is a hypersensitive skin reaction that occurs after exposure to Iodine. It is a well-known adverse reaction after intravenous iodine-containing contrast medium, but cases occurring after oral exposure are rare. A six-year follow-up study in one centre looking for any skin lesions occurring after oral radioiodine therapy for thyrotoxicosis, noted an incidence rate of 2.1% in 141 patients. The skin lesions can be acneiform, erythematous, urticarial, hemor...

A 26-year-old woman was referred to our outpatient clinic, presenting with growing left sided neck mass. She was in remission of Graves’ disease for the last two years.Ultrasound examination revealed isoechogenic nodule with microcalcifications in the upper third of the left thyroid lobe measuring 9×6×6 mm and conglomerate of lymph nodes on the left side of the neck, the largest node measuring 37×21×13 mm. Behind the lower pole of the left thyroid lobe...

Background: Peripheral arterial disease is a disorder due to obstruction of blood supply to extremities. Diabetes mellitus and hypertension are predisposing factors.Objective: To determine if the presence of concurrent hypertension increases the risk of peripheral arterial disease (PAD) in Nigerians with type 2 diabetes.Methods: This was a cross-sectional study that included 160 persons living with diabetes mellitus (60 subjects ha...

The incidence of Alzheimer’s disease (AD) is higher in women than men. Our study aimed to investigate the behavioral, biochemical, and histological changes in lipopolysaccharide (LPS)-induced AD, to study effect of estrogen in AD clarifying the possible involved underlying mechanisms and its modulation by progestsserone. Groups: Female albino rats were divided into control, AD, AD+ovariectomy (OVX), AD+OVX+estrogen replacement and AD+OVX+estrogen+pr...

Background: Copeptin is used as a diagnostic marker for acute myocardial infarction, adrenomedullin as a prognostic marker for congestive heart failure. Both hormones may be involved in pathophysiology of metabolic syndrome.Methods: We have used sera of the ‘Silent diabetes study’ (1). Sera of 920 patients were eligible for this analysis. All patients underwent an oral glucose tolerance test, patients with previously known diabetes were exclude...

Human adipose tissue provides abundant source of mesenchymal stem cells, which can be easily and safely harvested as compared with human bone marrow.The aim of this study was to differentiate a viable osteoblast and adipocyte cell culture from mesenchymal stem cells, an experimental model to study the interrelation between adipocytes and bone forming cells, osteoblasts.Materials and methods: Subcutaneous adipose tissue liposuction ...

Background and aims: We aimed to establish the frequency of vitamin D deficiency and analyse its association with gestational diabetes (GDM).Material and methods: In this descriptive, case control and cross sectional study, pregnant women were screened at 24–28 weeks of pregnancy using a 75 g, 2 h oral glucose tolerance test. Fourthy-six GDM diagnosed (case, group 1) and 43 healthy pregnants (control, group 2) were recruited. Plasma 25-hydroxyvitami...