Searchable abstracts of presentations at key conferences in endocrinology

ea0073ep160 | Pituitary and Neuroendocrinology | ECE2021

A pituitary TSH and GH co-secreting adenoma presenting with thyrotoxicosis, but no symptoms of acromegaly: a case report

Nagy Rea , Anna Vágvölgyi , Szucs Nikolette , Scheich Balint , Nyari Gergely , Hortobagyi Tibor , Barzo Pal , Valkusz Zsuzsanna

TSH producing pituitary adenomas are a rare cause of thyrotoxicosis. These tumors account for only 1–2% of the pituitary adenomas. Co-secretion occurs in 30% of thyrotropinomas and requires careful investigation and subsequent follow up.A 43-year-old male presented with hand tremor and tachycardia. He was found to have elevated TSH, free T4 (FT4) and free T3 (FT3), but did not get treatment for years. In 2019 he developed atrial fibrillation. TSH wa...

ea0074ncc9 | Highlighted Cases | SFENCC2021

A rare case of Hypocalcaemia – A diagnostic dilemma

Abeyaratne Dayakshi , Healy Ultan , Naziat Auditi , Tomlinson Jeremy , Pal Aparna , Hannan Fadil , Thakker Rajesh , Shine Brian , Jafar-Mohammadi Bahram

Case history: A 38-year-old woman presented with blepharospasm, cramping of the hands, and paraesthesia primarily affecting the face and hands. Symptoms had been present for 10 years but had been progressive over the previous 12 months. Symptoms were consistent with neuromuscular instability. Hypocalcaemia and elevated Parathyroid hormone (PTH) were confirmed. Past medical history was notable for anorexia nervosa in remission. Family history was non-contributary. Hypocalcaemia...

ea0074ncc29 | Highlighted Cases | SFENCC2021

A triumvirate of macroprolactinoma, apoplexy and aneurysm: what is the optimal management strategy?

Mathara Diddhenipothage Shani Apsara Dilrukshi , Anguelova Lia , Amarouche Meriem , May Christine , Jafar-Mohammadi Bahram , Joseph Robin , Cudlip Simon , Pal Aparna

Case history: A 57-year-old male with well controlled primary hypertension presented with acute onset severe headache while exercising, associated with nausea and vomiting. He had no visual or other neurological symptoms. The pain settled with analgesics in ED. He reported four transient similar episodes during the preceding 18 months. There were no symptoms suggestive of pituitary or other endocrine dysfunction, including hyperprolactinaemia. Clinical examination was unremark...

ea0077op3.1 | Reproductive and Neuroendocrinology | SFEBES2021

Discordant growth hormone and insulin like growth factor-1 values are associated with an increased mortality over concordant normal values in patients treated for acromegaly

Abeyaratne Dayakshi , Kaniuka-Jakubowska Sonia , Plummer Zoe , Archer Natasha , Lakmal Fonseka Chathuranga , Ayuk John , Peter James , McNally Richard , Michael Orme Stephen , Rees Aled , Pal Aparna , Wass John

Background: Growth hormone (GH) and Insulin like growth factor 1 (IGF-1) discordance in patients with acromegaly is a well-recognised phenomenon. It is unclear whether this is associated with increased mortality and morbidity compared to patients with concordant normal results.Methodology: A retrospective study was conducted on the United Kingdom Acromegaly Registry (UKAR). A comparison of mortality and morbidity was performed among four groups categoris...

ea0081ep691 | Pituitary and Neuroendocrinology | ECE2022

Genomic and epigenomic aspects of Aspirin antitumoral effect in pituitary adenoma

Szabo Borbala , Krokker Lilla , Meszaros Katalin , Saskői Eva , Nemeth Krisztina , Szabo Pal , Szucs Nikolette , Czirjak Sandor , Patocs Attila , Butz Henriett

Background: In our previous works the interdependence of DNA demethylation with proliferation and differentiation of pituitary neuroendocrine tumours (PitNET) and the inhibitory effect of Aspirin on pituitary cell proliferation were demonstrated. Although the role of Aspirin in epigenetic regulation was described in other malignancies, its correlation with pituitary tumorigenesis is currently unknown.Our objective: was to investigate the genomic and epig...

ea0086p88 | Neuroendocrinology and Pituitary | SFEBES2022

Cabergoline in acromegaly – a multicenter, retrospective, cohort study of non-irradiated patients using current criteria for disease control

Urwyler Sandrine A , Samperi Irene , Lithgow Kirstie , Mavilakandy Akash , Matheou Mike , Ayuk John , Bradley Karin , Pal Aparna , Reddy Narendra L , Karavitaki Niki

Background: Cabergoline monotherapy or in combination with somatostatin analogue (SSA) has been reported in few studies with IGF-1-normalization-rates 0%-100%(monotherapy) and 42%-60%(combination therapy). However, in these studies, inclusion of irradiated patients is a potential confounder and currently proposed disease control criteria (normal IGF-1, GH<1 mg/l) have not been applied.Aim: Investigate the efficacy of cabergoline monotherapy or as add...

ea0068p31 | Abstracts | UKINETS2019

Transformation of non-functional metastatic pancreatic neuroendocrine tumour to functional insulinoma; a rare but recognised phenomenon

Anguelova Lia , Healy Ultan , Tadman Michael , Weaver Andrew , Fryer Eve , Patel Neel , Boardman Phillip , Soonawalla Zahir , May Christine , Pal Aparna , Grossman Ashley , Jafar-Mohammadi Bahram

We present the case of a 54-year-old woman with known metastatic non-functional pancreatic NET since 2004 that developed new debilitating recurrent hypoglycemia in 2013. The patient presented in 2004 with disseminated malignancy. Radiology revealed a large pancreatic mass associated with multiple liver lesions and abdominal lymphadenopathy. Liver biopsy confirmed well differentiated NET. Initial treatment with cisplatin etoposide chemotherapy was poorly tolerated and discontin...

ea0065p137 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Long term outcomes following parathyroidectomy in patients with multiple endocrine neoplasia type 1: A retrospective cohort study

Healy Ultan , English Katie , Bacon Hannah Elizabeth , Grossman Ashley B , Shine Brian , Thakker Rajesh V , May Christine JH , Pal Aparna , Mihai Radu , Jafar-Mohammadi Bahram

Primary hyperparathyroidism (PHP), usually due to multigland hyperplasia, occurs in >90% of patients with multiple endocrine neoplasia type 1 (MEN1). The literature is divided on the optimal surgical management for such patients. We report a retrospective cohort study on the long-term outcomes associated with limited, subtotal, or total parathyroidectomy as initial surgery for PHP in MEN1. The primary endpoint was recurrent PHP defined as an adjusted serum calcium >2.6 mmol/l ...

ea0065p285 | Neuroendocrinology | SFEBES2019

The argument for growth hormone day curve testing in acromegaly; significant discrepancy between mean growth hormone and random growth hormone levels

Healy Ultan , Kahn Shoaib , Vincent Alex , Martinez Jacinto , May Christine J H , Wass John , Shine Brian , Jafar-Mohammadi Bahram , Pal Aparna

Endocrine Society guidelines recommend random growth hormone (RGH) <1 mcg/l as indicative of biochemical control of acromegaly. Growth hormone (GH) control may also be determined using the mean GH (MGH) of a growth hormone day curve (GHDC). We report a retrospective analysis of 461 consecutive GHDCs, from 121 patients with treated acromegaly, performed in a single centre between 2009 and 2019. Each GHDC contained 7–9 GH measurements (mean 8.9) taken at regular interva...

ea0063p1046 | Pituitary and Neuroendocrinology 3 | ECE2019

Recovery of the hypothalamic-pituitary-adrenal and gonadal axes following trans-sphenoidal adenomectomy, a single centre experience

Pofi Riccardo , Gunatilake Sonali , Macgregor Victoria , Cudlip Simon , Joseph Robin , Lenzi Andrea , Tomlinson Jeremy W , Jafar-Mohammadi Bahram , Isidori Andrea M , Pal Aparna

Hypopituitarism is a potential complication of trans-sphenoidal adenomectomy (TSA). Prediction of pituitary function (PF) recovery would inform hormonal replacement strategies. However, the frequency of re-testing of PF is variable across centres. The aim of this study was to determine rates, time and predictors of 6-weeks (6 w) recovery of hypothalamo-pituitary adrenal (HPA) and gonadal function after TSA.Methods: We performed a single-centre, retrospec...