Endocrine Abstracts

Introduction: Atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, regulates several physiologic parameters including diuresis and natriuresis, and lowers arterial, blood pressure.It has been reported that plasma concentrations of ANP rise in response to acute hyperglycaemia in diabetes (1) (2) and this may indicate a neurohormonal response to limit target organ damage (3).We investigate if in situation chr...

Introduction: Its has been suggested that atrial natriuretic peptide (ANP) may contribuye to the development of microalbuminuria in diabetes mellitus.Plasma ANP concentration have been reported to be elevated in association with microalbuminuria, all of wich predict the future development of overt nephropathy in diabetes (1).Key players in neurohormonal activation include neuropeptides and their receptors wich include the ANP (2).<...

Introduction: Gender identity disorder (GID) is a disagreement between biological sexual differentiation and self-declared gender identity. The aetiology of GID remains unclear, although endocrinological, neuroanatomical and psychosocial factors are all thought to be causally involved. Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, polycystic ovarian morphology, and biochemical and/or biological signs of hyperandrogenism. Most women with PCOS also ex...

The CNC is a dominantly syndrome, characterized by spotty skin pigmentation, endocrine overactivity and myxomas (Carney & Young 1992), associated with lentigines and blue naevi; the disease links to 17q22-24, and its mutations have been identified in the genes PRKAR1α. The most common endocrine manifestations affect two o more endocrine glands, including acromegaly, thyroid and testicular tumours and ACTH-independent Cushing’s syndrome due to primary pigmented no...

Many marine sponges have been shown to produce metabolites with cell growth and endocrine altering activities. We tested crude extracts (1.0 mg/ml) from two species (AV and SB) for effects on levels of an important cell cycle regulatory protein, cyclin B1; cell cycle growth-phase (sub-G1/Apoptosis, G1, S, and G2/M), as well as on cell survival in SW-13 human adrenal carcinoma cultures. Polyacrylamide gel electrophoresis studies of cyclin B1 levels indicate a 60-90 % reduction ...

Introduction: Vitamin D deficiency is a prevalent condition worldwide. Low serum 25(OH)D levels are associated with several diseases, being age and obesity strongly related to hypovitaminosis D. In addition, several genetic variants have also been associated with lower and/or higher 25(OH)D levels.Objective: We aimed to assess the potential influence of age, BMI, waist circumference and genetic variants on the efficacy of 12-month treatment with calcifed...

Introduction: Everolimus is a drug selective inhibitor of mTOR and approved by the FDA in 2011 for treatment of neuroendocrine tumors of pancreatic origin unresectable. Our objective was to evaluate the efficacy and safety of everolimus in a patient with malignant pancreatic head insulinoma.Case: This is a 31 year old man who complains of epigastric pain, dizziness, sweating and syncope related to exercise. During admission is objectively severe hypoglyc...

Introduction and objectives: In clinical practice many professionals are involved in the diabetes treatment. To facilitate this work, we present a computer program, based in recommended guidelines, to improve the management of insulin therapy, called insulinator. We evaluated the correlation between these and clinical practice.Materials and methods: Insulinator has been made so that using a number of variables (weight, HbA1c and glycemic control) offer a...

Pseudohypoparathyroidism (PHP) is a term applied to a heterogeneous group of disorders whose common feature is resistance to parathyroid hormone. Most of the PHP forms are caused by defects in GNAS: PHP-Ia (characterized by PTH and TSH resistance with Albright Hereditary Osteodystrophy) is caused by heterozygous inactivating mutations in those exons of GNAS encoding the α subunit of the stimulatory G-protein, and the autosomal dominant form of PHP-Ib (PTH an...

Introduction: Bilateral sampling of the inferior petrosal sinuses is an accurate test to diagnose Cushing’s disease and distinguish it with the ectopic ACTH syndrome. The aim of the study was to review the petrosal sinus samplings carried out during last 10 years in our hospital.Methods and material: The medical histories of patients admitted for suspected Cushing’s disease in the last 10 years (from 2005 till 2015) were reviewed. There were se...