Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep23 | Adrenal and Cardiovascular Endocrinology | ECE2022

Determination of 18-hydroxycortisol, 18-oxocortisol by HPLC–MS/MS in the differential diagnosis of various forms of primary aldosteronism

Romanova Natalia , Platonova Nadezhda , Troshina Ekaterina

Introduction: Aldosterone synthase participates in the key reactions of aldosterone synthesis – 11-hydroxylation, 18-hydroxylation and, finally, 18-oxidation. In recent works devoted to evaluating the effectiveness of hybrid steroids in the differential diagnosis of subtypes of primary aldosteronism (PA), it is worth emphasizing the experience of using high-performance liquid chromatography – tandem mass spectrometry (HPLC-MS/MS), which allows detecting even very low...

ea0090ep904 | Reproductive and Developmental Endocrinology | ECE2023

Morphofunctional and receptor status of endometrium in women with autoimmune thyroid diseases and pregnancy loss

Fris Ksenia , Andreeva Elena , Platonova Nadezhda

Objective: To determine the incidence of endometrium pathology in women with autoimmune thyroid pathology and history of reproductive losses, including an assessment of histological images and immunohistochemical (IHC) analysis of the endometrial receptor status.Materials and methods: A prospective cohort study included a clinical and instrumental examination of 84 women aged 18 to 45 years with a history of 1 to 3 consecutive pregnancy losses. Patients ...

ea0049ep126 | Clinical case reports - Pituitary/Adrenal | ECE2017

Clinical case of aldosterone-producing adrenocortical carcinoma

Krivosheev Alexey , Voronkova Iya , Platonova A , Britvin Timur

Aldosterone-secreting adrenocortical carcinoma (ACC) is rare neoplasm, which detected in 2.5% of active ACCs.Clinical case: A 58 years old female, was admitted to our clinic with complaints of high blood pressure, back pain, weakness, convulsions. Biochemical evaluation confirmed primary hyperaldosteronism (serum aldosterone 1012 pg\ml, serum renin concentration 0.5 mkME\ml, aldosterone-renin ratio 202.4, hypokalemia 1.2 mmol\l). There was no evidence of...

ea0081ep1000 | Thyroid | ECE2022

Assessment of thyroid function in healthy pregnant women living in iodine deficiency regions

Rybakova Anastasia , Platonova Nadezhda , Nikankina Larisa , Malysheva Natalia , Troshina Ekaterina

Background: During pregnancy, the physiology of the thyroid gland undergoes important changes. As a result, change levels of thyroid hormones. In the latest clinical guidelines, experts have recommended to perform population-based studies to determine reference intervals for thyroid hormones.Aim: To evaluate the reference intervals of free thyroxine in different trimesters of pregnancy in women living in regions with mild iodine deficiency.<p class="...

ea0067o43 | Oral Presentations | EYES2019

Vitamin D deficiency in pregnant women in Russia Federation

Rybakova Anastasia , Platonova Nadezhda , Troshina Ekaterina , Nikankina Larisa

Pregnant women are at risk of developing diseases associated with deficiency of essential micronutrients.Objective: To assess the prevalence of vitamin D deficiency among pregnant women and its dependence on the trimester of pregnancy.Methods: We examined 476 pregnant women at different gestational periods from three regions of Russia (Moscow, Ivanovo, Smolensk). Concentration of 25(OH)vitamin D (ng/ml) was estimated by immunometri...

ea0063p15 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Immunohistochemical characteristics of adrenal tumors in patients with primary aldosteronism

Romanova Natalia , Selivanova Lilya , Platonova Nadezhda , Troshina Ekaterina , Abrosimov Aleksandr

Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...

ea0063p900 | Diabetes, Obesity and Metabolism 3 | ECE2019

The results of diabetic foot syndrome screening among rural patients with diabetes in Uzbekistan

Ibragimova Nilufar , Shakirov Khamidulla , Babakhanov Bakhodir , Kokareva Lyudmila , Platonova Oksana

Diabetic foot syndrome (DFS) is currently considered the most severe of all late diabetes complications, resulting in deteriorating health outcomes, increased disability and reduced life expectancy.Aim: To study the frequency of occurrence of DFS in rural peoples with diabetes in Uzbekistan.Methods: Upon the international project WDF08-379 ‘Prevention of lower limb amputations in people with diabetes in Uzbekistan’, imple...

ea0063p901 | Diabetes, Obesity and Metabolism 3 | ECE2019

The role of ‘Diabetic Foot’ rooms in the organization of specialised help to patient with diabetic foot syndrome in Uzbekistan

Ibragimova Nilufar , Kamalov Telman , Shakirov Khamidulla , Kokareva Lyudmila , Platonova Oksana

Of all the late complications of diabetes, foot lesions are the most preventable. The multidisciplinary approach to providing specialized help for people with diabetes can prevent the amputations in 49–85% diabetic foots.Aim: The organization of specialized help to patient with diabetic foot syndrome (DFS) by the establishing the network of ‘Diabetic foot’ rooms and training of multidisciplinary team of specialists (endocrinologist, surgeo...

ea0063ep143 | Thyroid | ECE2019

Clinical case of giant goiter with chronic lymphoid leukemia

Romanova Natalia , Platonova Nadezhda , Troshina Ekaterina , Voskoboynikov Valeriy , Abrosimov Aleksandr

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...

ea0049ep736 | Diabetes complications | ECE2017

Improvement of specialised help to patient with diabetic foot syndrome in Uzbekistan

Ibragimova Nilufar , Kamalov Telman , Shakirov Hamidulla , Platonova Oxana , Kokareva Lyudmila

Goal: Decrease a number of lower limb amputations in PDM in Uzbekistan by improvement of specialised help given to patients with DFS.Materials and methods: Prior to 2010 there were only 2 ‘Diabetic foot’ rooms in Tashkent, Uzbekistan. In 2010–2012, CPA ‘UMID’ jointly with Uzbekistan Ministry of Health and Research Centre for Endocrinology implemented a project ‘Prevention of lower limb amputations in people with diabetes mel...