Searchable abstracts of presentations at key conferences in endocrinology

ea0081p499 | Thyroid | ECE2022

Variation of anti-TSH receptor antibodies after iodine-131 therapy

Vieira Ines , Monteiro Martim , Soeiro Paula , Rodrigues Dircea , Costa Gracinda , Paiva Isabel

Introduction: Graves’ disease (GD) is a systemic autoimmune disease characterized by lymphocyte activation and synthesis of anti-TSH receptor antibodies (TRABs). Higher values of TRABs are associated with a higher risk of Graves’ ophthalmopathy and dermatopathy. Iodine-131 therapy (RAI) is one of the well-established options in GD, but it can cause a transient increase in TRABs.Objectives: To evaluate the evolution of TRABs after RAI; to identi...

ea0090p308 | Calcium and Bone | ECE2023

Therapeutic Options for Inoperable Local Relapse of Parathyroid Carcinoma with Symptomatic Hypercalcemia: a Case Report

Filipa Araujo Barbara , Carreira Ana , Moreno Carolina , Rodrigues Dircea , Paiva Sandra , Paiva Isabel

Introduction: Parathyroid carcinoma (PC) is an extremely rare malignancy. A complete surgical excision is often difficult, and persistent/recurrent disease occurs in up to 65% of cases. Progression often leads to symptomatic hypercalcemia, the major contributor to poor quality of life and mortality. Treatment options beyond surgical resection are limited. Denosumab is an approved therapy for refractory hypercalcemia of malignancy, and its use in unresectable PC has been descri...

ea0041ep818 | Obesity | ECE2016

Metabolically healthy obesity: exploring the paradox

Ventura Mara , Lages Adriana , Rodrigues Dircea , Oliveira Patricia , Melo Miguel , Martins Diana , Oliveira Diana , Carrilho Francisco

Introduction: Obesity is a chronic disease associated with multiple comorbidities, defined by BMI, without considering the metabolic state of the patient. There are few data on the proportion of obese patients without metabolic syndrome (MS).Objective: To characterize patients considered to be metabolically healthy (MH) followed at the obesity outpatient clinic of one University Hospital, and to compare this group with a group of obese patients with MS.<...

ea0059p057 | Clinical biochemistry | SFEBES2018

Genetic susceptibility to type 1 diabetes: genomic variants in the vitamin D pathway

Almeida Joana , Rodrigues Dircea , Carrilho Franscisco , Guimaraes Joana , Lemos Manuel C

Type 1 diabetes mellitus (T1D) is an autoimmune disease that results from the destruction of insulin producing β cells, in genetic susceptible individuals. Vitamin D (Vit D) is mostly known for its role in bone and calcium metabolism, however it is also involved in the modulation of the immune response. Serum levels of vitamin D partly depend on diet and sunlight exposure. However, genetic factors are also involved. Patients with T1D have been reported to have a higher pr...

ea0099p503 | Endocrine-Related Cancer | ECE2024

Presurgical lactate dehydrogenase (LDH) levels: A risk factor for disease progression in operated adrenocortical carcinomas

Carreira Ana , Guiomar Joana , Festas Diana , Catarino Diana , Rodrigues Dircea , Moreno Carolina , Melo Miguel , Paiva Isabel

Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy with high recurrence and poor prognosis. Lactate dehydrogenase (LDH) is an enzyme of the glycolytic pathway that is associated with tumour progression in several cancers. To date, evidence on the prognostic value of LDH in ACC is limited.Aims: To assess the impact of LDH in disease-free survival (DFS) in operated ACC.Materials and methods: Retrospective cohort study ...

ea0099ep622 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Sometimes It’s Lupus – A Case of Hydroxychloroquine-Induced Hypoglycemia

Rodrigues Gustavo , Monsanto Alice , Carvalho Tania , Ribeiro Cristina , Gouveia Sofia , Rodrigues Dircea , Paiva Isabel

Introduction: Therapy with hydroxychloroquine (HCQ) and chloroquine (CQ) constitutes a rare but documented cause of hypoglycemia in non-diabetic adults. The physiopathological mechanism is not fully understood, and symptoms may appear several years after starting treatment. In this paper, we describe the clinical presentation and investigation of a case of hypoglycemia attributed to HCQ therapy. Clinical Case: A 60-year-old female patient was referred fo...

ea0099ep669 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Pre-surgical Factors and Their Influence on Therapeutic Response to Bariatric Surgery

Monsanto Alice , Carvalho Tania , Rodrigues Gustavo , Ventura Mara , Rodrigues Dircea , Paiva Isabel

Introduction: Bariatric surgery continues to stand as the most effective therapeutic intervention in treating severe obesity. However, a portion of patients experiences less satisfactory outcomes, diminishing the overall beneficial impact of this intervention. Identifying predictive factors for unsatisfactory responses to bariatric surgery could represent a crucial step in evaluating candidates, enabling the establishment of personalized care.Methods: Re...

ea0081p580 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypoglycemia and impared hypoglycemia awareness: frequency and relevance in type 1 diabetes under continuous subcutaneous insulin infusion

Mafalda , Carreira Ana , Vieira Ines , Barros Luisa , Melo Miguel , Rodrigues Dircea , Oliveira Patricia , Baptista Carla , Moreno Carolina , Paiva Isabel

Introduction: Continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes (T1D) reduces the risk of hypoglycemia. Hypoglycemia remains a treatment-limiting factor. Impared hypoglycemia awareness (IHA) occurs in 25% of T1D cases and seems to be underestimated by continuous glucose monitoring (CGM). Glycemic variability (GV) is a increasingly valued parameter as a predictor of hypoglycemia and risk of chronic complications.Objective: Analysi...

ea0081p666 | Pituitary and Neuroendocrinology | ECE2022

Inferior petrosal sinus sampling in differential diagnosis of adrenocorticotropic hormone (ACTH)-dependent cushing’s syndrome: a tertiary centre experience

Araujo Catia , Martins Ferreira Mafalda , Reis Guiomar Joana , Moreno Carolina , oliveira patricia , Baptista Carla , Gomes Leonor , rodrigues dircea , Paiva Isabel

Introduction: Inferior petrosal sinus sampling (IPSS) has been considered to be the gold standard for differential diagnosis of Cushing’s Disease (CD) and ectopic ACTH secretion (EAS).Aim: To describe the experience of our centre in performing IPSS, its safety and efficacy; assess remission rates from transphenoidal surgery and clinical course; approach to the difficulty in the etiological diagnosis of ACTH-dependent Cushing’s Syndrome.<p c...

ea0081p450 | Reproductive and Developmental Endocrinology | ECE2022

Influence of polycystic ovary syndrome on in vitro fertilization and relationship with the Asn680Ser polymorphism in FSHR gene

Vieira Ines , Filipa Ferreira Ana , Carvalho Alexandra , Dias Conceicao , Fernandes Silvana , Rodrigues Dircea , Cortesao Paulo , Almeida Santos Teresa , Paiva Isabel

Introduction: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility. Its influence on the results of in vitro fertilization (IVF) is controversial, and generally not isolated from the effect of obesity. A relationship between the FSH receptor (FSHR) polymorphism Asn680Ser and the risk and phenotype of PCOS has been studied with conflicting results.Objectives: To analyze the influence of obesity and PCOS on the gonadal axis...