Endocrine Abstracts

Introduction: A retrospective study of the year 2003, of 1314 women with GDM, was performed.Patients and methods: Two groups according to pre-pregnancy BMI: Go - BMI&gE;30 Kg/m2; Gno BMI<30 Kg/m2. Mean age 32.9±5 years, A1c<6% in both groups. Influence of BMI in different variables was analysed: family history of DM, weight gain during pregnancy; blood pressure, need of insulin, gestation age at the beginning of insulin...

Extracts of black cohosh (BCE) are frequently used as an alternative to conventional HRT to treat menopausal symptoms, particularly in Germany and the United States. In fact, BCE is the 14th most popular herbal product in the US and in 2003 sales were at least $15.7 million. Evidence for an increased incidence of breast cancer in long-term users of HRT has reduced its use and may increase the use of alternative treatments. These still require rigorous scientific investigation,...

Introduction: The objective of this study is to detect whether the correction of hypomagnesaemia would help to relief the symptoms of hypocalcaemia that occurs after thyroidectomy. Methods: This prospective study comprised 35 patients who had thyroidectomy between September 2001 and June 2002. Thirteen patients had total thyroidectomy (TT), thirteen had total lobectomy on one side and subtotal lobectomy on the other side (TLSL) and nine patients had hemi...

Interspecies transmission of prion diseases both centrally and peripherally is associated with longer incubation periods and lower effective titres to within species transmission, a phenomenon called the 'species barrier'. Research into interspecies transmission and disease pathogenesis is crucial for understanding disease risk for vCJD, which has been persistently linked to BSE. Host genetics, transmission route and strain of infective agent have generally been shown to affec...

IntroductionThe malignancy risk of an adrenal nodule is based on clinical symptoms (rapid onset of hypercortisolism and hyperandrogenism; mass symptoms) and imaging characteristics. These suspicious criteria include boundary irregularities, heterogeneity, dimension>6 cm and density>20 HU (CT). However, these are not absolute criteria.Case reportWe report the case of a 43 years-old female patient with a histor...

Background: IVF is an effective treatment for infertility, however it may be complicated by the potentially life-threatening ‘ovarian hyperstimulation syndrome’ (OHSS). OHSS is an iatrogenic condition, resultant on the mode of triggering oocyte maturation. Kisspeptin safely triggers oocyte maturation in women at high risk of OHSS, but has yet to be compared with current triggers of oocyte maturation (hCG or GnRH agonist).Meth...

Background: IVF is an effective treatment for infertility, however it may be complicated by the potentially life-threatening ‘ovarian hyperstimulation syndrome’ (OHSS). OHSS is an iatrogenic condition, resultant on the mode of triggering oocyte maturation. Kisspeptin safely triggers oocyte maturation in women at high risk of OHSS, but has yet to be compared with current triggers of oocyte maturation (hCG or GnRH agonist).Meth...

Childhood obesity is a serious public health challenge. Bariatric surgery is gaining popularity as a treatment modality for severely obese adolescents.Backgrounds: To report the safety and 1 year outcome data on morbidly obese adolescents that underwent bariatric surgery at a tertiary hospital in the UK.Methods: A retrospective review of patients (mean preoperative BMI 50.4 kg/m2; mean BMI SDS +4.2) who underwent bariatr...

Introduction: Hypopituitarism is a rare entity that can have different aetiologies. Symptoms are usually progressive and non-specific; therefore, many patients are underdiagnosed and untreated. We present a clinical case of a patient presenting septic shock, hyponatremia and central hypothyroidism.Case report: A 46-year-old man was admitted in ICU for septic shock of unknown origin and multiorgan failure. Hormonal profile showed central hypothyroidism, p...

Introduction: The Dandy-Walker complex (DW) comprises a rare intracranial malformation of the posterior fossa and multiple organ anomalies. The association with endocrine pathology is rare - described in isolated cases (Kallman syndrome, primary hypothyroidism (PH) and central precocious puberty). Noonan syndrome (NS) is a genetic disease usually diagnosed at birth, with variable phenotype. Most cases have AD transmission, with the PTPN11 gene mutation responsible for 50%....