Endocrine Abstracts

Introduction: Juxtaglomerular cell tumour (JCT) or Reninoma, is a rare cause of curable secondary hypertension, usually presented as a small renal tumour and treated by tumorectomy or partial nephrectomy (PN). Minimally invasive treatment such as percutaneous radiofrequency ablation (PRFA) has gained popularity over the last decade to treat small tumors. We report the case of a woman with secondary hypertension due to JCT, successfully treated with PRFA....

Introduction: Clinical research studies over the last 15 years have reported a significant burden of hypopituitarism in survivors of traumatic brain injury (TBI). However, these endocrine anomalies remain underdiagnosed.Patients and methods: We are studying data from a series of 75 TBI patients. They had a basal hormonal test, and dynamic confirmation tests if necessary. Somatotropic deficiency was defined by growth hormone (GH) remaining under 3 μg...

Introduction: Thyroid disorders are quite common during pregnancy complicated by diabetes mellitus.Objective: The aim of our study was to detect thyroid disorders in a group of diabetic pregnant women.Patients and methods: Rétrospective study involving 243 pregnant women with diabetes followed in consultation or hospitalized in Endocrinology and Diabetology department of Ibn Rochd University Hospital of Casablanca, over a peri...

Introduction: The prison environment is a space that involves some restrictions. However, diabetic patients require special attention. The aim of this work is to evaluate the impact of this area on the glycemic control and the metabolic profile.Patients and method: Descriptive cross-sectional study carried out on a day of health campaign in a penitentiary center, in the sector for men, and concerned the 62 known diabetic patients of the institution.<...

Definition: Fake hypoglycaemia in children and adults is due to self-administration of insulin or insulin secretagogue. They represent one of the best described facets of the Münchhausen syndrome. Here we report four cases of false hypoglycemia following insulin injection.Material and method: Prospective study that took place over 2 years to collect 4 hospitalized cases for etiological assessment of severe hypoglycaemia up to 0.2 g/l and complicated...

Introduction: Immune checkpoint inhibitors (ICPIs) are recent approved drugs used in malignant melanoma, non-small-cell lung cancer and renal cell cancer. They act by activating host T cell against malignant antigens. Immune checkpoint blockade can lead to breaking of immune self-tolerance, thereby inducing autoimmune/autoinflammatory side effects, such as endocrinopathies. It may affect thyroid, adrenal and pituitary. We present two ICPIs induced thyroiditis cases.<p clas...

Introduction: Hodgkin lymphoma (HL) survivors may develop a range of long-term complications that arise years after therapy. Among these, the endocrine dysfunctions are a major concern. Aim: To investigate the long-term endocrine effects of HL treatment.Methods: Revision of the HL patients’ medical files who were followed at our Endocrine Late-effects Clinics.Results: We studied 178 patients (86 (48.3%) were female), whose mea...

Context: Many pediatric cancer survivors have endocrine conditions. After alkylating agents, steroids, methotrexate and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by worldwide guidelines.Objective: The objective of the study was to describe the endocrine outcomes of 764 patients followed during a 20 years period in our out-patient clinic.Design: The design was a retrospective ...

Introduction: Chemotherapy may be an important cause of primary infertility, especially in girls submitted to this therapy at very young ages.Clinical case: A 20-year-old female was diagnosed with acute lymphoblastic leukaemia at the age of 1. She was submitted to chemotherapy: intrathecal methotrexate and cyclophosphamide and i.v. doxorubicin, vincristine, mercaptopurine, asparaginase and bone marrow transplantation at the age of 2. She was ref...

Although initially considered rare, the incidence of pancreatic neuroendocrine tumours (P-NETs) has progressively increased. A population-based study conducted in England and Wales (1986–1999) found that 5-year survival was 29% for non-functioning and 41% for functioning tumours when considering well-differentiated P-NETs. Traditional treatments show very limited effectiveness; novel targeted therapies are, therefore, required and identification of key molecules driving n...