Endocrine Abstracts

Introduction: Testicular tumours are very rare in children and usually present as painless enlargement of the testis. Germ cell tumours account for the majority of testicular tumours in young people and embryonal carcinomas are a common component of germ cell tumours.Case report: A 9.8 year old boy presented with the development of pubic and facial hair over a period of 2 years. He had a growth spurt (Height +3 SDS and bone age advanced to 14.8 years) an...

Background: Polycystic Ovary Syndrome (PCOS) is associated with insulin resistance, hyperandrogenism and dyslipidaemia but the effects of these disturbances on long-term health are not known.Aims: To determine the relative risk of diabetes, cancer, large vessel disease (LVD) and death for young women diagnosed with PCOS.Design: Data were extracted from The General Practice Research Database (GPRD), a longitudinal, anonymised resear...

Introduction: Patients with diabetes are twice as likely to have anxiety and depression compared to general population. Diabetic patients with depressive symptoms are less likely to adhere to dietary recommendations and treatment regime leading to poor glycaemic control. Evidence has shown that the treatment of psychological conditions can lead to improvement in health outcomes.Aims: To investigate the effectiveness of using a brief questionnaire to scre...

We present a case of a 52 year old man with a past medical history of primary hypothyroidism on treatment, presenting with elevated TSH levels, suggesting inadequate thyroxine replacement. The patient was managed with 200 mcg of thyroxine for 14 years with no compliance issues. TSH levels failed to normalise despite increasing the dose of thyroxine. In addition to elevated TSH levels the patient noted progressive leg swelling and associated shortness of breath over the precedi...

Introduction: In the United Kingdom, the prevalence of type 1 diabetes in the under-15s is rising fast, an increase of 80% is expected by 2020 and even higher, 125%, in the under five age group. The National Service Framework Standard recommends that all children/young adults with diabetes should receive consistently high quality care and they, with their families, be supported to optimise the control of their blood glucose and all aspects of their subsequent development.<...

Introduction: In postmenopausal women the rate of bone remodeling increases. Trace elements are known to influence bone metabolism. The aim of the study was to assess serum concentrations of some elements in pre- and postmenopausal women with and without osteopenia.Methods: Serum concentrations of magnesium, copper, cadmium and vanadium were measured by inductively coupled plasma atomic emission spectroscopy in 51 postmenopausal women (19 women with oste...

Medullary thyroid cancers (MTC) account for about 5% of thyroid cancers. The biochemical hallmark of MTC is the secretion of calcitonin (CT). CT levels are both a key feature of pre-operative diagnosis and post-operative follow up. CT screening in a cohort of over 10 000 patients with thyroid nodular disease has demonstrated that a positive CT test has a higher diagnostic sensitivity and specificity for MTC than fine needle aspiration (FNA). They may also secrete carcinoembryo...

Introduction: Osteoporosis affects a large percentage of the elderly population. Since the disease is preventable, diagnostic techniques are of major importance. Furthermore, the dentist is the most regularly visited doctor in this population and panoramic radiographs are the most frequently used imaging modalities for these patients. The purpose of this study was to evaluate the radiomorphometric indices on panoramic radiographs of post-menopausal females.<p class="abstex...

Context: Prolactinomas are the most common functioning pituitary adenomas & it is recognised that gender has an influence on presentation and management of this condition.Objective: To examine the effects of gender on presentation and response to treatment in a large cohort of adults with confirmed prolactinoma (MRI performed and macroprolactin excluded).Design & patients: This retrospective cohort study design used an elec...

Introduction: High sensitive CRP (hsCRP) has been reported to associate with an increased risk of cardiovascular disease. There is some evidence on apoE polymorphism in relation to the parameters of inflammation. We have investigated the association between APOE genotypes and hsCRP levels in an Iranian population.Materials and methods: We performed a cross-sectional study of 966 subjects (419 men and 547 women) from the Tehran Lipid and Glucose Study. hs...