Endocrine Abstracts

A 47-year-old female presented to the Emergency department following an episode of loss of consciousness at home that her daughter had identified as due to hypoglycaemia (using her husband’s capillary blood glucose meter 1.1mmol/l) and treated. She reported several episodes of fainting, sweating and generalised weakness over 6 months which improved after eating snacks. There was no previous history of diabetes; she had been diagnosed with Graves’ disease 6 months pre...

The effect of androgen on angiogenesis has been documented. However, its molecular mechanisms underlying has not been well illustrated. Here, we show that treatment with an androgen receptor (AR) agonist, metribolone (R1881) at a range of concentrations (0.05–5 nM) or dihydrotestosterone (DHT) at a range of concentrations (0.4–40 nM) caused concentration-dependent inhibition of proliferation in human umbilical venous endothelial cells (HUVEC). The R1881-induced proli...

Aim: Our previousstudies have shown evidence for insulin-releasing actions of some amphibian skin peptides; including esculentin-2CHa. However, there is a need to further improve the potency of some of this peptides and to characterize their other beneficial effects. This study investigates the effect of a Leu31→Lys substitution on the insulin-releasing and immunomodulatory effects of esculentin-2CHa.Methods: BRIN-BD11 cells were incubat...

Introduction: Isolated ACTH deficiency (IAD) is a rare disease which is characterized by secondary adrenal insufficiency with low cortisol production and normal secretion of pituitary hormones except ACTH. Isolated ACTH deficiency has rare association with Hashimoto’s disease which is characterized by autoimmune origin. This suggests the possibility of common autoimmune process affecting both the pituitary and the thyroid gland. We report a case of IAD with Hashimoto&#146...

Introduction: The most common cause of thyotoxicosis is Graves’ disease. Thyroid storm mostly presents with fever, tachycardia, arrthyhmia, jaundice, congestive heart failure and consciousness. We report a rare case of severe hypoalbuminemia with thyroid storm. To our knowledge it is the first case of severe hypoalbunemia due to thyrotoxicosis in literature.Case: Forty one years old female had been followed up with the diagnosis of Graves’ dise...

Introduction: Diabetic nephropathy is the leading cause of chronic renal failure worldwide. Related to the increased glucose and its metabolites, activation of renin–angiotensin–aldosterone system, and increased oxidative stress are important in renal deterioration. The studies indicate that suppression of renin–angiotensin–aldosterone system slow down diabetic nephropathy; Nigella sativa decreases blood glucose and oxidative stress. Were viewed th...

Introduction: Impaired glucose tolerance and diabetes mellitus are frequently seen complications of acromegaly. Insulin resistance due to chronic growth hormone (GH) excess and inhibition of insulin and glucagon secretion by long-acting somatostatin analogues (SA) used in the treatment are the main reasons of the impaired glucose tolerance.Objective: To determine the effect of long-acting SA treatment on glucose homeostasis regarding the insulin resistan...

Introduction: Common reasons of chronically elevated liver enzymes are; fatty liver associated with alcohol abuse or obesity, chronic viral hepatitis, autoimmune hepatitis, chronic bilier disease and hereditary metabolic disorders. Adrenocortical insufficiency can also cause elevated liver enzymes. Until now, there are few cases in the literature with abnormal liver function associated with Addison’s disease. We reported this case to kept mind the Addison’s disease w...

Introduction: Periodic review of hospital deaths is important to know the changing pattern of mortality in our environment. Ankara Ataturk Education and Research Hospital is a tertiary center with 18 in-patient beds in Endocrinology and Metabolism Clinic. Critical patients with endocrine-related diseases are also followed in intensive care unit. In this study, we aimed to evaluate demographic characteristics, hospitalization indications and causes of death in patients who died...

Introduction: Coexistence of type 1 diabetes mellitus (DM) and autoimmune thyroid diseases was shown in previous studies. Thyroid dysfunctions and thyroid autoantibody positiveness were reported in 23–25 and 27–44% of patients with type 1 DM, respectively. In recent years, thyroid ultrasonography (US) is widely used to diagnose autoimmune thyroid diseases with regard to its ability to define thyroid morphology and echogenity. In this study, we aimed to evaluate thyro...