Endocrine Abstracts

Advanced research to investigate possible methods of treatment in patients with metabolic syndrome is required. Adipocytokines are secreted by the adipose tissue. These polypeptides and their functions are also known last few years.Adipocytokines are also anti-inflammatory and antiatherogenic, and they increase insulin sensitivity. As result of these skills, adipocytokines should be useful for diagnosis and treatment for metabolic syndrome. In this study...

Serum TSH is the most sensitive index of thyroid function in the absence of hypothalamic–pituitary disease.However, TSH reference limits are controversial, particularly the upper limit. District and age subpopulations have unique TSH distribution. We investigated characterization of thyroid hormones in Japanese elderly. 859 participants (mean age 74.3 years) over 60 years without known thyroid disease were surveyed.Percentages...

Background: Asian has higher prevalence of diabetic nephropathy and end-stage renal disease as compared to Caucasian. No study to date has evaluated whether multifactorial intervention was associated with remission of microalbuminuria in type 2 diabetic Asian population. We evaluated the effect of tightly controlling multiple factors on the remission of diabetic nephropathy in type 2 diabetic Chinese with microalbuminuria.Materials and methods: A total o...

Introduction: The clinical differentiation between androgen insensitivity syndrome (AIS) and 5 alpha reductase deficiency (5-ARD) can be difficult. Presenting features may be similar and initial investigations may still not be discriminatory.Methods: Case notes on a total of ten patients with the initial diagnosis of AIS or 5-ARD were retrospectively reviewed.Results: All ten children had a 46XY male karyotype. Four children were r...

Background: Klotho was first identified as a gene involved in aging. A recent publication identified klotho as a possible tumour suppressor in breast cancer. We have previously reported decreased expression of klotho in tumours of primary hyperparathyroidism, here we have investigated whether klotho expression is silenced by CpG methylation of the promoter region.Materials and methods: Methylation status of klotho was determined by MSP in 40 parathyroid ...

In order to understand the mechanisms that underpin gonadal development, we have conducted a subtractive screen to identify transcripts expressed differentially during the sex-determining period. Suppression subtractive hybridization PCR was performed on cDNA derived from 12.5 dpc male and female gonadal ridges. Clones were tested for differential expression by RNA whole mount in situ hybridization. Those localizing to testis cords were further tested on germ cell-deple...

Background: Growth hormone (GH) is known to have stimulatory effects on bone tissue through a complex interaction of GH, IGF-1 and IGFBPs. The gonadal status is also thought to influence bone metabolism. Bone mass in patients with acromegaly reflects the long-time effects of GH excess on bone. However, data on bone status in acromegaly have been conflicting.Objective: The object of the study was to examine the impact of chronic GH excess on bone mass and...

A 64 year old man presented in 1992 with a dense bitemporal hemianopia and no endocrine symptoms. CT showed a large pituitary adenoma with suprasellar extension. He underwent transphenoidal resection of the tumour. Histology showed a typical chromophobe adenoma with no immunohistochemical staining. His vision recovered.He was followed regularly with serial MRI scan. No change was seen in the size of the residual intrasellar tumour. Pituitary testing show...

The importance of the differentiation between the apparent benign clinical condition of macroprolactinaemia and that of true hyperprolactinaemia, which requires therapy, is becoming widely recognised. Laboratories routinely rely on prolactin recoveries of less than 40 percent following treatment of sera with polyethylene glycol (PEG) to distinguish between the former and latter conditions. However, the 40 percent threshold employed is arbitrarily defined with little scientific...

Background and Aims: to study the clinical significance of the s E- selectin (CD 62) in the serum of patients with Type 1 Diabetes and Microangiopathy (diabetic nephropathy (DN) and retinopathy (DR).Materials and Methods: 32 patients (14 men & 18 women, age mediana 26,4 years) were under supervision in the period from 1999 to 2001 years. The cohort examined was subdivided into 3 groups:1. with newly diagnosed diabetes (n = 11) ...