Endocrine Abstracts

Background: Men with obesity often have low total and, with increasing adiposity, also free testosterone (T) levels, which can partially restore when they lose weight. Although this is in part explained by lower sex-hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not fully unraveled whether changes in androgen metabolization contribute to this phenomenon.Aim: Investigating metabolisation of sex steroids d...

Background: During IVF treatment, a pharmacological dose of recombinant FSH (rFSH) is used to induce multi-follicular growth (controlled ovarian stimulation; COS). An insufficient dose of rFSH negatively impacts the number of oocytes retrieved, whereas an excessive dose risks the potentially life-threatening complication ‘ovarian hyperstimulation syndrome’. Hence, appropriate rFSH dosing is regarded as a key treatment decision affecting both the success and safety of...

Background: During 2017–2018 the diabetic team at our Foundation Trust participated in the RCPCH diabetes quality improvement collaborative to support work in reducing the mean HbA1c of our patient cohort. It is widely acknowledged that a consistent approach is vital in working towards HbA1c targets. One area of focus of our quality improvement work was to standardise the management of hypoglycaemia. As a team we decided to follow the BSPED hypoglycaemia guideline (2016) ...

Background: The adrenocortical carcinoma (ACC) is a rare malignancy with poor outcomes and overall survival of less than 40%. Different prognostic factors were evaluated in patients with ACC. We analyzed overall survival (OS) and recurrence-free survival (RFS) in patients with ACC depending on Ki-67 and ENSAT staging.Methods: We performed a retrospective study on 62 ACC patients treated at the Croatian Referral Center for adrenal gland disorders from 200...

Introduction: Adrenal vein sampling (AVS) is a gold standard in the assessment of the cause of primary aldosteronism (PA). It is technically demanding procedure having the high rate of failure, even in expert centres. Our study aimed to investigatewhether the data on aldosterone and cortisol concentration from successfully cannulated adrenal vein could determine the subtype of PA in certain patients with partially successful AVS.Materials and methods: Th...

Introduction: The widespread use of neuroimaging leads to the increased detection of asymptomatic pituitary adenomasnot causing significant mass effect. Their optimal management remains unclear.Aim of the study: To explore the natural course of incidentally found nonfunctioning pituitary macroadenomas.Patients and Methods: This was a longitudinal study that enrolled patients with clinically nonfunctioning pituitary macroadenomas wh...

Background: Radiotherapy (conventional and/or radiosurgery) is an effective treatment option in patients with acromegaly when biochemical control of the disease cannot be achieved by medication and/or surgery. Purpose: The aim of our study was to evaluate the efficacy of gamma-knife radiosurgery or conventional radiotherapy in the treatment of GH-secreting pituitary adenomas.Materials and methods: We conducted a retrospective analysis of 22 acromegaly pa...

Aim: In this study we have compared the adequacy rates of FNA samples between more experienced and less experienced operators in thyroid FNA.Introduction: The prevalence of thyroid nodules is estimated to be about 4–7%, increasing up to 50% in the adult population. US guided FNA has become the preliminary investigation of choice for thyroid nodules, as it is widely available and has been proven to increase diagnostic efficacy....

Soy phytoestrogens (PE) have been shown to improve insulin resistance and lipids but may adversely affect thyroid function.Objective: To determine the effects of soy PE on thyroid function, insulin resistance and lipid parameters in patients with subclinical hypothyroidism.Design: A randomised, double-blind, crossover study was undertaken involving 60 patients with subclinical hypothyroidism. Patients were randomly assigned to eith...

Acromegaly is a complex disease with an insidious onset and diagnosis can be delayed. The aim of the study was to investigate the diagnostic delay (DD), for patients with acromegaly due to a pituitary tumour in Sweden. Data were obtained from the Swedish National Patient Register. Patients diagnosed between January 1, 2011 and December 31, 2013 in Sweden were included (n=135, 69 men, 66 women). For these patients, the occurrence of pre-defined relevant comorbidities w...