Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0026p673 | Diabetes therapy | ECE2011

Effects of estradiol+drospirenone on sexual function in postmenopausal women with type 2 diabetes mellitus

Pogorelova A S , Berketova T U , Ragozin A K

Introduction: Sexual dysfunction is more prevalent in postmenopausal women with diabetes mellitus.Objective: The aim of the study was to prospectively evaluate the effects of oral estradiol+drospirenone on sexual function in postmenopausal women with type 2 diabetes mellitus.Methods: The study included 86 postmenopausal women with type 2 diabetes mellitus who were randomized into two groups: 44 women received oral 17β-estradio...
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ea0016p376 | Growth factors | ECE2008

Overexpression of IGFBP-2 in transgenic mice affects muscle protein accretion, skeletal myofibre growth and metabolism

Rehfeldt C , Renne U , Wolf E , Hoflich A

To elucidate the functional role of IGFBP-2 for in vivo skeletal muscle growth and function, skeletal muscle cellularity and metabolism as well as body growth and composition have been studied in a transgenic mouse model overexpressing IGFBP-2. Postnatal growth rate of transgenic mice (n=20) was clearly reduced from day 21 of age by 6–8% (P<0.05) compared with non-transgenic controls (n=37). At the final day of live (day 72 of age) body pro...
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ea0006p55 | Clinical case reports | SFE2003

PERSISTENT VOMITING: AN UNCOMMON PRESENTING SYMPTOM OF THYROTOXICOSIS IN A WOMAN WITH TYPE 1 DIABETES MELLITUS

Srinivas|#Shankar U , Rutter M , Ewins D

Graves' disease is known to occur with increased frequency in patients with Type 1 diabetes mellitus (T1DM) especially women. Undiagnosed thyrotoxicosis can aggravate glucose intolerance and precipitate diabetic ketosis and ketoacidosis. Among the various presenting symptoms of hyperthyroidism, vomiting is a recognized but uncommon symptom.We present the case history of a 30 year old woman with T1DM of 10 years duration presenting with a short history of...
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ea0006p56 | Clinical case reports | SFE2003

RECOGNIZING PARATHYROID CARCINOMA

Srinivas|#Shankar U , Rutter M , Ewins D

Most cases of primary hyperparathyroidism are due to either parathyroid adenoma or hyperplasia. Parathyroid carcinoma is a rare cause of hyperparathyroidism, usually diagnosed post operatively .Prognosis is poor with a 5 year survival rate of 50-75%.A 74 year old man presented with a 2 week history of weight loss, anorexia and constipation but no abdominal or bone pain. Past history included hypertension and gout and was not on drugs known to cause hyper...
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ea0073aep510 | Pituitary and Neuroendocrinology | ECE2021

Is this just vitiligo? Nelson is hiding

Vis Maarten De , Brigitte Velkeniers

A 64-year old man presented to our endocrinology clinic with progressive lumbar pain that had developed two months earlier. He had undergone bilateral adrenalectomy for Cushing disease and two years later transsphenoidal resection for Nelson tumor. On physical examination, the patient had remarkable hyperpigmentation due to ACTH hypersecretion periorbital, peri-auricular and in the lower-neck region. These findings were clearly evident in his case due to the extensive facial v...
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ea0073aep49 | Adrenal and Cardiovascular Endocrinology | ECE2021

Hair cortisol levels in patients with adrenal incidentalomas compared to healthy controls

Athanasouli Fani , Mytareli Chrysoula , Andreadaki Evangelia , Petychaki Foteini , Savelli Akrivi , Asonitis Nikos , Anna Angelousi

BackgroundAdrenal incidentalomas (AI) are present in 3–10% of the general population. Up to 20% of them may have autonomous cortisol secretion (ACS). However, subclinical hypercortisolism isn’t clearly defined. The 1mg dexamethasone suppression test (ODST) is the most widely accepted for the screening of these patients. Recent data suggest that hair cortisol should be considered as a routine test for the screening of Cushing syndrome.<p cla...
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ea0037ep1150 | Endocrine tumours | ECE2015

A one-stop multi-disciplinary VHL clinic: patient benefits and feedback

O'Toole S , McAndrew L , Drake W , Srirangalingam U

Introduction: Von Hippel-Lindau (VHL) syndrome is a complex multi-organ disorder with significant associated morbidity and mortality. Patients see multiple specialities and have many clinic appointments which can significantly disrupt their lives. In 2012 the St Bartholomew’s VHL multi-disciplinary clinic was set up. It consists of an amalgamated one-stop clinic for patients and their families when all relevant specialities are seen in one sitting. The major aims were to:...
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ea0029p7 | Adrenal cortex | ICEECE2012

The combined use of nocturnal salivary cortisol and urinary cortisol to creatinine ratio in the evaluation of cycling in patients with Cushing’s syndrome

Graham U. , Hunter S. , McDonnell M. , Mullan K. , Atkinson B.

Cyclical Cushing’s syndrome is typically detected by collecting sequential daily early morning urine (EMU) samples for cortisol to creatinine ratio over a 28 day period. More recently nocturnal salivary cortisol (NSC) measurement has been shown to be a sensitive means of screening for Cushing’s syndrome. The Endocrine Society have suggested that NSC may be used to assess patients for cyclical Cushing’s however there is limited evidence that it correlates with th...
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ea0029p18 | Adrenal cortex | ICEECE2012

Use of the 250 mcg short synacthen test in the diagnosis of primary aldosteronism

Graham U. , Hunter S. , McCance D. , Atkinson B. , Mullan K.

Aberrant and upregulated eutopic receptors have been identified in vitro in patients with primary aldosteronism (PA). We previously identified an exaggerated aldosterone response to synacthen in patients with PA versus healthy controls. In this study we aimed to evaluate whether the synacthen test differentiates between patients with PA and essential hypertension (EH).The 250mcg intramuscular synacthen test was performed after 30 minutes recumbenc...
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ea0029p50 | Adrenal cortex | ICEECE2012

Intercurrent Illness Dose Regimen in Adrenal Insufficiency with a Dual Release Hydrocortisone Formulation Derived from Population Pharmacokinetic Modelling

Simonsson U. , Skrtic S. , Lennernas H. , Johannsson G.

Patients with adrenal insufficiency need adjustment of the hydrocortisone (HC) dose during an intercurrent illness. Current recommendation to double the daily HC dose at each occasion does not consider the non-linear dose proportionality in bioavailability i.e. doubling the dose gives less than 100% increase in exposure. We have developed an intercurrent illness dose regimen for a once daily dual release HC tablet using population pharmacokinetic (POPPK) modeling.<p class=...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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