Endocrine Abstracts

There is limited evidence on the effect of potassium (K+) supplementation on endothelial function. Three studies suggest a beneficial effect in healthy volunteers and mild hypertensives. However potassium increases aldosterone due to a direct effect on the adrenal gland and there is evidence that aldosterone excess is detrimental to cardiovascular health. We therefore aimed to determine the effect of potassium supplementation on endothelial function in patients with >10% c...

Neurohypophyseal diabetes insipidus (DI) is said to be caused by familial forms in about 5% of cases1. Hereditary transmission is autosomal dominant in most families and is caused by a mutation in the arginine vasopressin (AVP) gene on chromosome 20p13, which encodes for a large precursor hormone.A 19-years old otherwise healthy patient seeked endocrine care for an inadequately treated DI. He reported about an undoubtful disease history with a...

Introduction: Involvement of different tissues and organs may be seen during the course of Graves’ disease (GD). We here aimed to present a case with GD and lung mass whose lung lesion disappeared after recieving antithyroid treatment.Case report: A 60 year old man admitted to our hospital with back pain. His thorax computed tomography (CT) revealed a 1.5×3 cm mass in lower right lobe. He was consultated by our clinic preoperatively before thor...

Background: Polycystic ovary syndrome is the most common endocrine disorder among women in their reproductive years. Apart from reproductive and metabolic manifestations, recently more attention has been paid to psychological features of this syndrome. The aim of the study was to evaluate the effect of PCOS on quality of life and to estimate the frequency of anxiety and depression in Polish women with PCOS.Methods: One hundred seventy five women with PCO...

GH is used primarily to increase adult height in short children with GHD/NSD with little knowledge about the impact of GH on health-related quality of life (HRQoL). Therefore this study was carried out to evaluate HRQoL in adult patients with childhood onset GHD/NSD at the end of GH therapy.HrQoL was measured by patient self-report using two generic questionnaires, SF36 and NHP. Patient data were compared to representative norm data. Clinical data as wel...

Aim: to study features of growth and development in teenagers with Diabetes Insipidus of central genesis.Material and methods: During 2009–2010 years we examined 37 teenagers with Diabetes Insipidus of central genesis. 19 boys (51.3%) and 18 girls (48.6%) among them. Mean age of boys and girls was 13.5 years.All patients underwent general clinical examination. Levels of STH, LH, FSH, prolactin, TSH, free thyroxin, cortisol, et...

Background: Craniopharyngiomas are embryogenic malformations which lead to eating disorders and morbid obesity due to hypothalamic involvement. The experience with laparoscopic adjustable gastric banding (LAGB) in obese craniopharyngioma patients is limited especially in regard to long-term effects and tolerability.Patients and methods: We are reporting on four patients with childhood craniopharyngioma diagnosed at age 2, 13, 12, and 20 years.<p clas...

Local glucocorticoids action depends on 11β hydroxysteroid dehydrogenase (11β-HSD) enzymes. Adipose tissues mainly express the 11β-HSD1, which activates inactive cortisone. Altered 11β-HSD1 and GLUT4 expressions have been reported in obesity. GLUT4 participates in the genesis and maintenance of insulin resistance/obesity, and could also be involved in the insulin resistant state observed in hypercortisolism. The aim of this study was to investigate the 11&#...

Back ground: Acute adrenal insufficiency is a life threatening condition with multiple aetiologies. The adrenal gland is susceptible to thrombosis and hemorrhagic infarction due to rich arterial supply and limited venous drainage. We present a case report of a simultaneously detected acute adrenal insufficiency due to bilateral adrenal haemorrhagic infarcts with ischemic bowel as the first manifestation of antiphospholipid syndrome (APS).Case history: A ...

Background: The growth hormone receptor (GHR) 6Ψ pseudoexon mutation (A to G at ds-1) is one of the most frequent mutations causing GH insensitivity. It causes aberrant mRNA splicing, leading to activation of a pseudoexon and insertion of 36 additional amino acids, resulting in a functionless receptor. Although IGF-I remains the mainstay of treatment for these patients we investigated the ability of RNA antisense oligonucleotides (ASOs) to correct aberrant GHR splicing us...