Endocrine Abstracts

Aim: To assess the relationship between clinical symptoms, growth hormone (GH) and IGF-1 during medical treatment for acromegaly.Methods and Patients: 6 patients, mean age 52y, (range 43-68), 4 males, were treated with Lanreotide SR (LAN). A growth hormone day curve (GHDC) and IGF-1 were assessed at week 0, pre LAN. All patients received LAN 30mg, 2weekly. GHDC was repeated at week 8, aiming for mean growth hormone (MGH) <5mu\/l. LAN was increased t...

Somatostatin (sst) acts via five G-protein-coupled receptors (sstr) that effect angiogenesis, cell proliferation and apoptosis. We have reported the expression of these receptors in normal endometrium and in this study we have extended those observations to the expression of sstr subtypes 1, 2, 3, and 5 within hyperplastic and neoplastic endometrium using immunohistochemistry. METHOD The avidin-biotin-peroxidase method was used to immunostain formalin-fixed, paraffin-embedded ...

We analysed thyroid function tests (TFT; tT4 +TSH ±fT4) and clinical outcomes in patients with thyrotoxicosis managed with the aid of a computerised Thyrotoxicosis Shared-Care Scheme (TSC) between 1994 and 2001. During this 7-year period, 900 patients had been managed via TSC. 319 were in TSC since receipt of the initial referral letter, of whom 268 commenced TSC by mid-2000 with at least 6 months subsequent follow up (FU) data in the same tT4 assay and were analysed i...

Normal range glycemia towards higher side has been shown to have a higher risk than lower range of glycemia(1).People with impaired glucose tolerance (IGT) with better glycemic control would be an ideal step towards prevention of coronary heart disease CHD.Prevalence of undiagnosed diabetes remains high(2). Diagnosis of diabetes is made too late in too many patients. By the time diagnosis is made complications have already settled ...

Background: Emerging evidence shows that diabetes mellitus causes structural and functional alterations in the brain. Recent studies have shown that diabetes may induce reductions in N-acetyl aspartate (NAA) and glutamate concentrations in the cortical grey matter, but few studies have performed the neurochemical profiling of other brain regions in patients with diabetes. Hence, the aim was to investigate brain metabolites in other brain regions of adults with diabetes.<p ...

Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pituitary and pancreatic islet tumours, and is due to mutations of the MEN1 gene, which encodes the tumour suppressor protein menin. MicroRNAs (miRNA) are non-coding single stranded RNAs that post-transcriptionally regulate gene expression. Alterations in miRNA expression, including downregulation of two miRNAs, miR-15a and miR-16-1, have been r...

The mechanisms of development and progression of essential hypertension (EH) and concomitant type 2 diabetes (DM2) still remain not completely studied, so the comprehensive evaluation of the contribution of various indicators to the formation of this comorbidity have scientific interest.The aim of the study was comprehensive assessment of the variability of anthropometric, echocardiographic and biochemical parameters in patients with EH and concomitant D...

Introduction: Anti-epileptic drugs (AED) adversely affecting bone health. However, individual variations between different AEDs exist and not all AEDs are equally toxic to the bone. There is almost equipoise about the effect of valproate on bone.Methods: We conducted a cross-sectional study assessing bone mineral density with dual energy X-ray absorptiometry at the hip and lumbar spine in 33 outpatients receiving valproate for ≥1 year and 36 health...

Aims and objectives: To assess the effect of Comprehensive Yogic Breathing Program on glycemic control, quality of life, and cardiac autonomic functions in diabetes.Material and methods: This is a prospective randomized controlled intervention trial. 120 diabetes patients who were having HbA1c between 6 and 8% for atleast 6 months were selected. Oral drug dose was adjusted to keep the HbA1c between 6 and 8. Plasma fasting glucose, post prandial plasma gl...

The aim of our study was to determine the possibility of engraftment and function of the native thyroid tissue in its autotransplantation in the thigh muscle in rabbits. The experiment included 10 animals species Chinchilla Breed at the age of 12–18 months – five females and five males. In order to simulate the animals primary postoperative hypothyroidism animal extrafascial thyroidectomy was performed, and then on the inside of the left thigh of the neurovascular bu...