Endocrine Abstracts

Recent findings suggested two-way interaction between bone and adipose tissue. Osteocalcin, a hormone of osteoblasts, was shown to stimulate insulin sensitivity by direct interaction with insulin. Adipose tissue has an important effect on insulin sensitivity by secretion of anti-inflammatory and proinflammatory adipocytokines like adiponectin and monocyte chemoattractant protein-1 (MCP-1). It is unknown whether they are related to bone metabolism.Aim of ...

Introduction: Bisphosphonates therapy is the standard of care in postmenopausal osteoporosis. In the HORIZON-RFT, annual i.v. Zoledronic acid (ZOL) 5 mg infusion significantly reduced the rate of new fractures by increased bone mineral density (BMD). We proposed to evaluate the effect of ZOL treatment in BMD change in a group of postmenopausal osteoporotic women assessed by DXA–BMD. We have proposed also to assess the adverse events of this treatment.<p class="abstext...

Fatty liver (Hepatic Steatosis) is common in men with type 2 diabetes mellitus (T2DM). Furthermore there is a high prevalence of testosterone deficiency (up to 40%) in this population. Testosterone replacement therapy (TRT) has been shown to reduce elevated serum liver transaminase levels in hypogonadal men. The testicular feminised (Tfm) mouse exhibits a non-functional androgen receptor (AR) and low circulating testosterone levels. We have previously shown that a high-fat die...

Hypogonadism is highly prevalent in men with type 2 diabetes (T2D) and/or cardiovascular disease (CVD). Low testosterone levels are associated with CVD risk factors including obesity, insulin resistance, dyslipidaemia and hypertension. Testosterone replacement therapy (TRT) has been shown to have beneficial effects on these parameters; however, safety needs to be verified. An audit of 308 (50% with T2D, 32.1% CVD, 82.8% ED) hypogonadal men (age 59.02±13.23 years; mean bas...

Introduction: Subjective fatigue is a common symptom in patients with coronary artery disease (CAD) and has a significant negative effect on quality of life of CAD patients. However, currently there are no studies evaluating possible association between endocrine measures and subjective fatigue in CAD patients. Therefore the aim of the current study was to evaluate possible associations of subjective fatigue with function of adrenal axis and thyroid axis in CAD patients.<p...

It is to delineate two categories of hypercalcemia: hypercalcemia associated with dysfunction of the parathyroid gland and hypercalcemia that occurs despite appropriate parathyroid suppression.There is casuistic model of 73 years old woman with several years personal history of hypercalcemia and clinical polyarthritis. After standard examinations there was diagnosed primary hyperparathyroidism. USG screening expected adenoma of parathyroid gland right do...

Introduction: Thyreotoxic periodic paralysis (TPP) is a very rare complication of hyperthyroidism in Caucasians. Furthermore there have been reported only a few cases that paralysis was induced by corticosteroids in patients with TPP.Case presentation: We report the case of a 35-years-old Greek sailorman who had a spider bite in his right hand during a trip in Mexico. He was admitted to local hospital due to the significant swelling of his arm, where he ...

Aim: We have proposed to study the modulation of the Notch pathway in diabetes having in mind the essential role played by the Notch system in the regulation of cell differentiation and angiogenesis.Methods: The effect of hyperglycemia on Notch system was studied in vitro and in vivo using western blot, reporter gene assay or evaluation of target genes (qRT-PCR). The functional consequences of the Notch system modulation were studied by the...

Aims: We present final Hellenic data from the INSTIGATE study which assessed direct costs, resource utilisation, and clinical outcomes in the first 24 months of insulin therapy in type 2 diabetic (T2D) patients.Methods: INSTIGATE was a prospective European observational study of patients with type 2 diabetes who had initiated insulin during usual care. Data were collected at baseline, when subjects initiated insulin (visit T1), then 3 (T2), 6 (T3), 12 (T...

Purpose: Diabetic patients (T2D) switch from short-acting insulin to rapid-acting analogue (H-A) and less commonly from A-H. The SWING study was designed to assess treatment costs, glucose control, satisfaction, and quality of life in T2D following H-A or A-H switches.Methods: SWING was a multinational, prospective, observational study of previously mentioned parameters associated with switching in either direction between any rapid-acting analogue insul...