Endocrine Abstracts

Epidemiological data suggests a correlation between phytoestrogen consumption and a reduced incidence of breast cancer. Current in vitro data is ambiguous, suggesting differential proliferative effects of phytoestrogens depending on ER expression status and exogenous estradiol levels. This study aims to characterise the growth inhibitory effects of the isoflavones genistein and daidzein using a panel of human breast cancer cell lines.Flow cytometry revealed low leve...

Red deer (Cervus elaphus ) antlers annually undergo rapid de novo development of new bone, skin and hair follicles in the spring. Antler development, and a mane on the neck in the winter season, are secondary sexual characteristics of red deer stags. Although androgens are involved, where they actually act in the antler is unclear.Therefore, we have explored the expression pattern of the androgen receptor in the developing region of antler...

Hypothyroidism is common with lithium therapy. Thyrotoxicosis is rare. Of 81 cases of thyrotoxicosis related to lithium therapy reported 22 were silent thyroiditis , 39 Graves' disease and 11 autonomous nodule.We report a 56 year old male who had been on lithium for the last four years for bipolar illness, was referred to us when he was found to be biochemically thyrotoxic on routine testing. The TSH was less than 0.01, FT37.3, FT4 154. On his visit to ...

Neoplasia and Endocrine Differentiation Research Group. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela. Santiago de Compostela, Spain. This has been an extraordinary year, where scientists have not been able to get close to the laboratory in many months. However, in the pituitary/hypothalamus we have outstanding contributions. Being at home does not mean stopping thinking, as highlighted by interesting reviews on th...

Background: The problem of eating disorders currently holds a special place in clinical practice. Bulimia nervosa is one of the main forms of eating disorders, characterized by difficulty in treatment, a long, recurrent course. Eating disorders are common in patients with type 1 diabetes mellitus (T1D), especially in adolescent girls.Case Presentation: In this article, we present a clinical case of a 29-year-old patient with T1D for 14 years and bulimia ...

Objective: To describe the clinical presentation of forefoot and midfoot diabetic foot ulcers (DFUs) complicated by osteomyelitis and their outcomes with conservative management in a multi-disciplinary care environment and determine predictors of ulcer healing.Methods: This is a retrospective study of all consecutive cases of DFUs complicated by osteomyelitis presenting to our multi-disciplinary diabetes foot clinic between 1st January and 30th June 2016...

There is experimental evidence that inhibition of the glycogen synthase kinase-3β (GSK-3β) by small molecule inhibitors induces a rapid, CRM1/XPO1-dependent nuclear export of the AR protein in human prostate cancer cell lines. By contrast nucleo-cytoplasmic shuttling of Q641X, a C-terminally truncated AR-mutant, remains unaffected by GSK-3β inhibition. In silico analysis of the AR C-terminus (amino acids [aa] 641-920) predicted two putative NES-sites, l...

Since the discovery of melanocortin 4 receptor (MC4R) as an important regulator of food intake it has been recognised as one of the major monogenic factors of obesity. However the mutations identified are usually very rare, not found in control subjects from the background population and can explain only a minor part of heritability (2–3%). Here we explore the role of non-synonymous mutations identified by MC4R sequencing in cohort of 380 severely obese individuals (BMI 3...

Aim: Studying of features autoimmune thyroiditis associated with rheumatoid arthritis (AIT/RA).Methods and materials: Twenty-nine women with AIT/RA were examined. Study design included: special protocol of anamnesis, sonography of thyroid gland, evaluation of thyroglobulin antibodies (Tg-Ab), thyreoperoxidase antibodies (TPO-Ab), the thyroid hormones (T3, T4) and TSH in serum. Two groups of patients have been allocated: I group (...

DTC carries a good prognosis when adequately treated by means of total thyroidectomy, iodine-131 (I-131) treatment and TSH-suppressive therapy, and carefully followed up (i.e. serum thyroglobulin, I-131 total). In some cases, however, false-positive scans can occur. A 42-yr-old woman with recurrent chest infections and bronchiectasis was submitted to total thyroidectomy because of a13 mm nodule in the right lobe that showed a papillary thyroid carcinoma at FNAB histological ex...