Endocrine Abstracts

Issues: Adolescent diabetes social stigma in India. Such diabetics needs proper guidance/information/treatment-counselling outlets. This is burning issue in developing-nations like India. Hence we all need to unite & form a comprehensive diabetes care & counselling policy plan at ECE conference. Treatment options must be suitable for developing-nations considering cost of Rx. Incorporating NGO’s in such efforts is very effective.Our Project ...

A 26-year-old man presented with a 3-month history of polydipsia, polyuria and nocturia. Physical examination was unremarkable. Random blood glucose was 5.1 mmol/l, sodium 147 mmol/l, serum osmolality 297 mOsm/kg, urine osmolality 81 mOsm/kg. A water deprivation test confirmed cranial diabetes insipidus. Magnetic resonance imaging (MRI) of his pituitary gland revealed nodular thickening of the pituitary stalk suggestive of inflammatory or neoplastic aetiology. He also complain...

Type 2 diabetes mellitus (DM2) is often associated with obstructive sleep apnea (OSA), according to the literature. Current approach in choosing the hypoglycemic therapy is based on individualization, but do not take into account the effect on OSA. The research purpose: to evaluate the effect of various hypoglycemic agents on the characteristics of OSA in patients with type 2 diabetes.Materials and methods: The study included patients with OSA and DM2, t...

The 1-mg overnight dexamethasone suppression test (DST) is a screening test for endogenous Cushing’s syndrome (CS). The principle is that dexamethasone (D) will suppress ACTH and cortisol (C) secretion in healthy individuals, but not in CS. We have studied the associations between D and C concentrations in patients without CS after 1-mg DST.Methods: On suspicion of CS, 59 patients received 1-mg D at 23 p.m. and next day at 8 a.m. blood was drawn for...

Cushing’s disease is the main cause of endogenous hypercortisolism. Comorbidities increase morbidity and mortality and the treatment is fundamentally surgical. Patients may use drugs to lower hypercortisolism as pre-surgical preparation and post-surgical treatment when cure is not reached.Objective: Evaluate the benefits and collateral effects of ketoconazole in Cushing’s disease.Methods: In 22 patients with Cushing’...

Numerous hormonal and metabolic disorders caused by thyrotoxicosis lead to serious complications, so early diagnosis and adequate treatment becomes very important in warning of functional and organic changes in several organ systems, particularly in the structure of bone tissue.The aim was study of the effectiveness of calcium and alendronate for prevention and treatment of BMD losing in experimental models of thyreotoxicosis.Mater...

Introduction: The combination of hypokalemia and hypercalcaemia is uncommon but potentially lethal. In primary hyperparthyroidism hypokalaemia most commonly occurs due to incomplete distal renal tubular acidosis. We present the first case of simultaneous primary hyperparathyroidism with Gitelman’s syndrome resulting in profound electrolyte imbalance.Case: A 48-year old man, referred with hypokalaemia (2.5 mmol/l) presented with a short history of ex...

Vitamin D (VitD) was shown to affect biology of vascular wall by regulating cell proliferation. However, its effects on vascular extracellular matrix (ECM) remain largely unaddressed. We investigated effects of VitD (calcitriol) on composition of ECM deposed by cultured endothelial cells (HAEC) and smooth muscle cells (HASMC) isolated from human aorta, and compared them to effects of ascorbate (VitC). Cellular monolayers were treated with or without vitamins for 72 h, then ECM...

Hyponatremia may manifest with nausea, disorientation, seizures, coma, cerebral edema and even death. The etiology of hyponatremia as paraneoplastic syndrome has been attributed most often to high levels of vasopressin. Correction of hyponatremia is usually successful at moderately low sodium levels, although it must be done slowly to prevent osmotic demyelination. Gastrointestinal stromal tumors (GISTs) rarely present paraneoplastic reactions, a few cases have been reported.<...

A 28 year old female with no significant medical history, 25 weeks into her second pregnancy was referred to endocrinology with adjusted calcium of 2.99 mmol/l. She had a short history of generalised aches and tiredness. Examination did not reveal any stigmata of MEN1 or the HPT-JT syndromes. There was no known family history of endocrine disorders. Her PTH was 7 pmol/l, confirming primary hyperparathyroidism. As parathyroid Tc-scintigraphy would be contraindicated in pregnanc...