Endocrine Abstracts

When patient was an 14-year-old, he presented with a short stature and underdeveloped external genitalia. The patient had not undergone normal pubertal development. Hormonal studies and clinical examination revealed the findings of anterior and posterior pituitary hormone deficiency: ADH, LH (0.2 mIU/l), FSH (1.22 mIU/l). Since then patient took different therapy for diabetes insipidus. Secondary sexual characters developed during patient received gonadotropin for a very short...

Glycaemic control remains poor among individuals with diabetes mellitus (DM) in Nigeria and is linked to a non-supportive family environment. Family-Integrated Diabetes Education (FIDE) has been shown to improve glycaemic control in studies among Hispanics and Caucasians. However, there is dearth of literature on its effectiveness among Africans; despite the close-knit nature of many African families. The study aimed at determining the effects of FIDE on glycosylated haemoglob...

Type 1 diabetes mellitus (T1DM) not only is congenital disease that known as insulin-dependent diabetes, often occurs in children and adolescents. Recent advances in quantitative proteomics including fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for underst...

The purpose of this prospective cohort study was to evaluate whether early insulin therapy is more advantageous in achieving long-term optimal glycemic control with improved B cell function than oral drugs in the recently diagnosed type 2 diabetes mellitus. Methods: Sixty consecutive patients with recently diagnosed type 2 diabetes mellitus were divided into 3 groups.The 1st group received 2 SC injections of premixed insulin. The 2nd group received bed time NPH and 3 injection...

A 35year old man presented to the cardiology clinic with effort dyspnoea, palpitations and light-headedness. He had just returned from a 6 month “round the world’ trip during which he had suffered a diarrhoeal illness. An echocardiogram performed in Bangkok revealed left ventricular dilatation but no other significant changes. A diagnosis of possible myocarditis was entertained and he was treated with 2.5 mg of Ramipril and 75 mg of Aspirin. When seen in the cardiolo...

Diabetes contributes to 80% mortality in coronary heart disease (CHD). Hyperglycaemia antedates diabetes and is a late stage in the series of events leading to diabetes.Stress hyperglycaemia on admission with acute myocardial infarction (AMI) has been reported to have an increased risk of in-hospital mortality/morbidity.We conducted a retrospective study of all AMI admissions to coronary care unit over a six-month period to see th...

18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2), and its clinical usefulness has not been clarified. We prospectively measured 18-oxoF, using highly sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS), in peripheral plasma of patients with primary aldosteronism (PA) who underwent adrenal venous sampling (AVS) to differentiate aldosterone producing adenoma (APA) from bilateral hyperplasia. The study was...

Purpose: Glucocorticoid excess causes obesity and hyperphagia (e.g. Cushing syndrome), but the molecular mechanism of glucocorticoid-induced hyperphagia is not fully understood. To clarify this point, we investigated here the phenotype of leptin and Corticotropin-releasing hormone (CRH) double knockout mice (DKO).Methods: Leptin-deficient ob/ob mice were bred with CRH-deficient mice for generation of DKO mice. We examined body weight, food consumption an...

The transcription factors Runx2 and osterix (Osx), which are known as downstream genes in BMP2 pathway, are essential for osteoblast differentiation and bone formation. Runx2 expression is normal in Osx null mice, but Osx is not expressed in Runx2 null mice, indicating that Osx acts as a downstream of Runx2. Here, we questioned whether or not all bones could be formed by BMP2–Runx2–Osx pathway or unknown their own gene axis. To answer this question, we first analyzed...

Background: Diagnosis of secondary adrenal insufficiency (SAI) during pregnancy is challenging due to physiological adaptations and progressive increase of cortisol level throughout the pregnancy (1). The 250-mg standard ACTH stimulation test (CST) is recommended for evaluation of adrenal hypofunction in pregnancy however, measurement of serum cortisol (SC) maybe misleading in patients with partial SAI. Furthermore, utility of salivary free cortisol (SaFC) (2) and serum DHEA-s...