Endocrine Abstracts

Introduction: We present a case of a patient with type two diabetes mellitus (T2DM) who started empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor and the P90X diet and presented with euglycemic DKA seven days later.Case Presentation: A male in his 5th decade of life with a history of T2DM presented for a routine office appointment and had a measured hemoglobin A1C of 9.3. His home diabetes regimen consisted of metformin and sitagliptan. D...

Introduction: The appearance and normal development of the anterior pituitary gland requires several signalling molecules and specific transcription factors, such as PROP1, POUF1, HESX1/RPX, LHX3, LHX4, PITX2, T-PIT, SOX2 and SOX 3. Gene mutations of these pituitary transcription factors may lead to different degrees of combined pituitary hormone deficiency (CPHD) associated or not with morphological changes of the hypothalamic–pituitary region.Mate...

Introduction: Despite extensive research into IQ scores in congenital hypothyroidism (CH) during childhood there is little information on adult outcome in terms of pragmatic measures such as educational achievement, employment, residency and relationships.Patients and methods: We present the results of a questionnaire-based study examining these outcome measures in Scottish adults with permanent CH born between 1979 and 1991. The unaffected siblings of o...

In breast cancer associations between p160 co-activator proteins and the development of resistance to endocrine treatment have been shown. We hypothesized that nuclear co-regulatory proteins may interact with non-steroid receptors. We investigated the effect of silencing the co-activator, SRC-1, on tumour cell growth in vitro. We also examined the MAPK activated transcription factors, Ets, as possible interaction proteins of the co-activator SRC-1 in human breast cancer. The e...

The capacity of the adrenal to produce steroids is controlled in part through the transcriptional regulation of steroid enzymes. Steroidogenic factor 1 (SF-1), an orphan nuclear receptor is thought to be central to the transcriptional regulation of all steroid hydroxylase enzymes. Recently co-regulatory proteins have been implicated in the modulation of nuclear receptor transcriptional activity. We hypothesised that classic and novel secretogogues, including forskolin, angiote...

Sex steroid hormones effect on the early embryo-development and regulate the calcium signaling in cardiac muscle. Progesterone (P4) has been reported to affect both blood pressure and other aspects of the cardiovascular system. To confirm the effect of P4 on early differentiation of mouse embryonic stem (mES) cells into cardiomyocytes, the hanging-drop method was performed to form embryoid bodies (EB). The mouse EBs (mEB) were suspended, attached onto six well plates and cultu...

Background: Early detection of residual or recurrent cancer in patients with differentiated thyroid cancer (DTC) is important, especially, when they do not uptake 131I uptake because these tumors do not likely benefit from radioiodine therapy (RAIT). We aimed to evaluate the usefulness of FDG-PET/CT as an early diagnostic work up in DTC patients with negative radioiodine whole body scan (I-WBS) and elevated stimulated Tg (sTg) levels.Methods: ...

Background: Polycystic ovary syndrome (PCOS) constitutes the most common endocrine disorder in women of reproductive age. Recently, the potential influence of endocrine disrupting chemicals (EDCs) on the development of PCOS has been suggested. The aim of the present study is to determine whether dihydrotestosterone equivalent concentration (DEQ) representing total androgenic activities including androgen derivatives from EDCs measured by chemically activated luciferase gene ex...

A 53-year-old retired military soldier had a 9 months history of recurrent blackouts predominately associated with blurred vision, feeling shaky, sweaty and they were mainly before meal. His past medical history included asthma, multiple shrapnel injuries, hearing impairment secondary to blast injury. He was on atorvastatin, ompeprazole and inhalers.He was admitted acutely to his local hospital and blood glucose 0.6 mmol/l was found. Prolonged 72 h fast ...

Introduction: This study aimed to examine whether altered Heart Rate Variability (HRV) could predict the risk of development of metabolic syndrome (MetSD) in Asians.Methods: We investigated health checkup records of 33 752 adults aged 20–65 years old who did health checkups and HRV measurement between April 2011 and June 2014 at Kangbuk Samsung Hospital, without MetSD, anemia, thyroid disease, malignancy, and heart disease. A 3-minute HRV recording ...