Endocrine Abstracts

Introduction: Acromegaly and Waldenstrom’s macroglobulinaemia are two rare diseases (about 3–4 and 10 cases/million per year respectively), the association between them is even more infrequent, one case being reported in the available literature.Case report: We present the case of a 74-years-old female (I.I.) suffering with both diseases. In 1997 acromegaly diagnosed by dysmorphic syndrome, than in 2004 hormonal/imagistical investigations (GH a...

Introduction: The association of multiple myeloma (MM) with primary hyperparathyroidism (pHPT) is very infrequent. In addition pHPT may be overlooked or later diagnosed, because on the one hand certain clinical and laboratory characteristics of MM, such as hypercalcaemia, asthenia, osteoporosis and impaired renal function overlap with the elements of pHPT, on the other hand modern pHPT include non-classical (e.g. normocalcemic or mild clinical) forms. We present the case of a ...

Antagonists of growth hormone-releasing hormone (GHRH-ant) may exert their antiproliferative effects directly on cancer cells, which are mediated by the tumoral GHRH receptors identified by us. Furthermore we showed that GHRH-ant are able to induce apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway. However, the molecular features involved in the antiproliferative effect of GHRH-ant have not yet been elucidated. To study this, gene expression profi...

Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting 6–10% of reproductive aged women. In young women with PCOS, multiple risk factors for cardio vascular disease (CVD) including dyslipidemia may be found and prevention is needed.Objective: This study aims to investigate the prevalence of dyslipidemia in Algerian PCOS women.Materials: A prospective study was performed (since 2004–2008) on 181 PCOS and 90 ...

Background: In addition to its normal spectrum of metabolic effects, insulin has been identified as a growth factor capable of promoting mitogenic activities. Thus, hyperinsulinemia, a consequence of insulin resistance, is regarded as a potential risk factor for the development of cancer in patients with diabetes. However, the mechanism of action of insulin in prostate cancer has not yet been completely elucidated. The aim of this study was to investigate whether insulin can d...

Background: IGF1R targeting emerged in recent years as a promising therapeutic approach in prostate cancer (PCa). The insulin receptor (IR) shares high structure homology with the IGF1R and activates similar signaling cascades. In recent studies we have shown that insulin’s mitogenic activities in PCa cells are mediated via the IR. Given the central role of IR in regulation of metabolism, most anti-IGF1R therapeutic strategies were designed to specifically inhibit IGF1R, ...

Introduction: It is well known fact that central lipid stores are related to glucose metabolism impairment. Standard anthropologic methods for measuring lipid stores centralisation are waist, waist to hip ratio and waist to height ratio. Still, often these markers fail to relate to difference in glucose metabolism between equally obese patients.Method: We analysed relation between waist line radius and subcutaneous adipose tissue thickness, determent wit...

Objective: To evaluate the effect of selenium on autoimmune thyroid diseases through ATPO-titers.Material and methods: Selenium (0.1–0.2 mg/day) was associated to basic treatment of thyroid dysfunctions in 21 female patients with high ATPO-levels (normal<34 U/ml). We followed the thyroid function and ATPO-values usually after 2–6 months of selenium administration.Results: Ten hypo-thyroid patients had Hashimoto’s...

Introduction: Persistent or intractable PHPT can lead to neuromuscular and psychiatric symptoms and may increase the long-term risk for cardiovascular disease and fractures. Cinacalcet (Mimpara/Sensipar) represents an innovative treatment option for this small group of patients, as it directly acts on the calcium sensing receptors on cell surfaces, reducing the severity of hypercalcemia.Purpose: To estimate the UK budget impact of cinacalcet in patients ...

Introduction: Chordomas are rare tumours that usually occur in adults, in children since 1923, <100 cases has been reported. It represent few than 5% of these tumours and most frequently develop in the skull base.Para cellar localisation is uncommon, cause hypopituitarism and oculomotor nerves palsy.Chordomas are believed to behave more aggressively than chordomas in adults.Case report: A 14-year-old boy ...