Endocrine Abstracts

Much less information is available on the thyroid hormones at different age groups, laying, non-laying and methimazole (MMI) treated japanese quails. All birds were kept under 14:10 hour light schedule and were provided feed and water adlibitum. Fifteen japanese quailsin each age groups, laying, non-laying and MMI treated were decapitated for collection of plasma. Thyroid hormones (T3 and T4) were estimated using ELISA commercial kits. The results showed that plasma thyroid ho...

Eight healthy pregnant goats, aged 2-4 years, were selected for this study. Blood samples were obtained in tubes containing EDTA at different stages of pregnancy, at parturition and on days 1, 7 and 14 postpartum. Blood from foeti was also collected on days 1 and 7 after their birth. Plasma was separated, frozen at -20 celsius till analysed for thyroid hormones (T3 and T4) using ELISA comercial kits. Thyroxine (T4) concentration was higher during prepartum, decreased significa...

Introduction: The guidelines of American Thyroid Association from 2011 include age over 30 as one of the risk factors for hypothyroidism in pregnancy. The aim of our study was to verify whether age increases the risk of autoimmune thyroid diseases (AITD) in pregnant women.Methods: We performed a cross-sectional study in 5223 unselected consecutive pregnant women in the 9th–12th gestational weeks. In a single laboratory, we measured serum concentrati...

The endocrine disruptor compounds (EDC) (e.g. chlorobenzenes (ClB), phenurone (PU), monurone (MU), diurone (DU)) are accumulative, lipophilic, chemical pollutants that can disturb the homeostatic balance and exert tumorigenic effects. The aim of the present study was to investigate the effects of EDCs on the adrenocorticotropic hormone (ACTH) and prolactin (Prl) release in primary cell cultures derived from rat normal adenohypophysis and prolactinoma.The...

Background: It has been shown that hypothyroidism is associated with atherosclerosis. The presence of atherosclerosis process could be registered by use of some Doppler Ultrasound parameters (DUP) – intima-media complex thickness (IMCT) and systolic velocity (SV). In this study we present initial DUP on the lower limb artery in treatment-naïve hypothyroid females and the influence of thyroid hormone levels and some metabolic components.Methods ...

Goiter prevalence (GP) and median UIC in population studies are both considered markers of iodine nutrition. Controversy exists which of them is more reliable.Aim: To assess correlation between UIC and thyroid volume in Polish schoolchildren.Material and methods: 9402 Polish schoolchildren (51.3% girls, 48.7% boys) aged 6–12 years were examined in 1999–2011 (‘Thyromobil’ action). 40.9% of children were born at l...

Introduction: The utility of screening for antibodies against thyroperoxidase (TPOAb) in early pregnancy remains controversial. The aim of our retrospective follow-up study was to examine the thyroid function of initially euthyroid TPOAb+ women at a longer period after delivery.Methods: We invited 822 women screened positive for thyroid disorders in the first trimester of pregnancy (9th–12th gestational week) for follow-up. This included measurement...

Background: There is increasing body of evidence suggesting for low vitamin D levels in humans. The levels of vitamin D in nonselect populations of Europe, Middle East, Asia and Latin America had been repeatedly shown to be as low as 20-30 μg/l.Aim: The aim of our study was to examine serum 25-hydroxyvitamin D [25-(OH)D] levels in young healthy premenopausal women in Slovak population.Subjects and methods: The participants (<i...

Introduction: Although some studies have shown elevated soluble interleukin 2 receptor (sIL-2R) in sera of patients with hematological malignancies and some autoimmune diseases, its role in serum is not fully understood.Patients and methods: The aim was to compare serum levels of sIL-2R in four groups of women (11 with Graves’ disease, 10 with Hashimoto’s thyroiditis, 11 with breast cancer and 10 healthy controls) and to test their possible rel...

IntroductionExenatide may provide weight loss in type 2 diabetes mellitus (T2D) via agonistic effect on GLP1 receptor. There is no study showing associations between free T4(fT4) and exenatide-related weight loss in T2D. We aimed to reveal the association between fT4 and exenatide-related weight loss, and change in thyroid functions with exenatide in euthyroid adult patients with T2D and obesity.Materials and Methods<p class="a...