Endocrine Abstracts

Hypoglycemia is an uncommon clinical problem in patients without diabetes mellitus. Potential aetiologies include drugs, critical illness, hormone deficiencies, and non islet cell tumors. In the absence of these causes, the possibility of accidental, surreptitious, or even malicious hypoglycemia should be considered. We present three cases of severe, prolonged hypoglycemia occurring spontaneously in healthy young men without a history of diabetes mellitus or chronic illness. A...

A 46-year-old gentleman presented with a history of general lethargy, weight gain, limb weakness, easy bruising and severe back ache. Examination showed central obesity, proximal myopathy, with marked thinning and extensive bruising of the skin. His blood pressure and glycemic control were suboptimal and resistant to treatment. Routine blood tests including a chest X-ray were normal. An overnight dexamethasone suppression test showed failed serum cortisol suppression (749 nmol...

A 51-year-old woman with no significant past medical history presented with left flank pain, accelerated hypertension, progressive deterioration in renal function and left sided pleuritic chest pain. CTPA revealed pulmonary oedema and left adrenal haemorrhage. Urinary catecholamines were marginally elevated (24 h Urinary Metadrenalines 7.58 μmol/24 h) raising the possibility of an underlying phaeochromocytoma. Short synacthen test showed a sub-optimal response (0 min cort...

Background and aims: Subjects with primary (PAI) and secondary adrenal insufficiency (SAI)/hypopituitarism have an increased cardiovascular mortality for reasons that are unclear. Arterial stiffness is an independent risk factor for increased cardiovascular mortality. We sought to measure arterial stiffness in subjects with AI and aimed to identify which factors might account for any increase observed.Methods: Ethical approval was obtained for this study...

Background: CB1 antagonism has potential benefits in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and peripheral action on adipose tissue. We have previously demonstrated the inhibitory effects of CB1 inactivation on preadipocyte proliferation and now extend these studies to in vitro adipogenesis.Aims: To compare the effects of CB1 agonism and antagonism on differentiation in both preadipocyte cell lines and ...

Introduction: Primary Hyperparathyroidism usually presents as bone disease, renal or with Gastro Intestinal Symptoms. Dental Symptoms as primary or presenting manifestations are rare. We report two patients who presented with edentulous jaw in young age, which resulted in investigations leading to the diagnosis for primary hyperparathyroidism.Material and methods: We report two patients operated in a tertiary referral Centre from Jan 2017–Dec 2017 f...

Universal reach of diabetes care and assurance of minimum standard of care is a milestone yet to be achieved. Application of artificial intelligence/machine learning (AI/ML) for diabetes care can help solve both these aspects of diabetes care.ObjectiveCreating a clinical decision support system using AI/ML approach for predicting best anti-diabetes drug class to be introduced to help optimally manage glycaemic control in people liv...

Objectives: Primary - Study of Correlation between Serum Osteoprotegerin, and Biomarkers of Bone Metabolism in Patients with treatment-naive Graves’ Disease (GD). Secondary- Serum level of Osteoprotegerin, TNF alfa and Biomarkers of Bone Metabolism in Patients 3 months after treatment of GD with methimazole (MMI).Material and Methods: A total of thirty-five treatment-naive newly diagnosed GD were recruited for the study, most of them were female. Al...

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterised by hypercalcemia, skeletal fragility, and renal stones with majority (75%) of parathyroid tumours localized to the inferior parathyroid glands. The reasons for this natural bias are not known till date. A probable reason may be due to inherent differences in the molecular milieu of normal superior and inferior parathyroid glands. Such questions cannot be answered using superior and inferior parathy...

Introduction: Noise in the operating room is an ongoing problem and impacts the outcome of surgery. Noise as stressor can produce a startle reaction and activate fight or flight response of the autonomic and endocrine system. The psychobiology of the stress as assessed by salivary cortisol level is a sensitive measure of allostatic load. In this study, we correlated salivary cortisol levels of the surgical team with noise measurement and also whether the noise in OR subjective...